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  • 1-10 ل  51 نتائج ل ""Class I Phosphatidylinositol 3-Kinases""

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Publication : international journal of molecular sciences
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Academic Journal

In Silico Discovery of a Novel PI3Kδ Inhibitor Incorporating 3,5,7-Trihydroxychroman-4-one Targeting Diffuse Large B-Cell Lymphoma.

  • Authors : Jia W; College of Chemistry and Chemical Engineering, Qilu Normal University, Jinan 250200, China.; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.

Subjects: Lymphoma, Large B-Cell, Diffuse*/Lymphoma, Large B-Cell, Diffuse*/Lymphoma, Large B-Cell, Diffuse*/drug therapy ; Lymphoma, Large B-Cell, Diffuse*/Lymphoma, Large B-Cell, Diffuse*/Lymphoma, Large B-Cell, Diffuse*/metabolism ; Molecular Docking Simulation*

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Oct 19; Vol. 25 (20). Date of Electronic Publication: 2024 Oct 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

EGFR and PI3K Signalling Pathways as Promising Targets on Circulating Tumour Cells from Patients with Metastatic Gastric Adenocarcinoma.

  • Authors : Piper AK; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia.; Molecular Horizons, University of Wollongong, Wollongong, NSW 2522, Australia.

Subjects: Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/pathology ; Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/drug therapy ; Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 May 20; Vol. 25 (10). Date of Electronic Publication: 2024 May 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Genetic Insights into Colorectal Cancer: Evaluating PI3K/AKT Signaling Pathway Genes Expression.

  • Authors : Świechowski R; Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.; BRaIn Laboratories, Medical University of Lodz, Czechoslowacka 4, 92-216 Lodz, Poland.

Subjects: Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/genetics ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/pathology ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 May 27; Vol. 25 (11). Date of Electronic Publication: 2024 May 27.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Additive Cytotoxic and Colony-Formation Inhibitory Effects of Aspirin and Metformin on PI3KCA -Mutant Colorectal Cancer Cells.

  • Authors : Gonçalves J; Unit of Biochemistry, Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.; Pinto S

Subjects: Metformin*/Metformin*/Metformin*/pharmacology ; Aspirin*/Aspirin*/Aspirin*/pharmacology ; Colorectal Neoplasms*/Colorectal Neoplasms*/Colorectal Neoplasms*/drug therapy

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 May 15; Vol. 25 (10). Date of Electronic Publication: 2024 May 15.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Dominant Role of PI3K p110α over p110β in Insulin and β-Adrenergic Receptor Signalling.

  • Authors : Zhang B; Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.; Luk C

Subjects: Class I Phosphatidylinositol 3-Kinases/Class I Phosphatidylinositol 3-Kinases/Class I Phosphatidylinositol 3-Kinases/*metabolism ; Insulin/Insulin/Insulin/*metabolism ; Proto-Oncogene Proteins c-akt/Proto-Oncogene Proteins c-akt/Proto-Oncogene Proteins c-akt/*metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 26; Vol. 22 (23). Date of Electronic Publication: 2021 Nov 26.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Transcriptional Regulation of PIK3CD and PIKFYVE in T-Cell Acute Lymphoblastic Leukemia by IKAROS and Protein Kinase CK2.

  • Authors : Dovat E; Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.; Song C

Subjects: Gene Expression Regulation, Leukemic*; Casein Kinase II/Casein Kinase II/Casein Kinase II/*genetics ; Class I Phosphatidylinositol 3-Kinases/Class I Phosphatidylinositol 3-Kinases/Class I Phosphatidylinositol 3-Kinases/*genetics

  • Source: International journal of molecular sciences [Int J Mol Sci] 2021 Jan 15; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 15.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Deletion of p53 and Hyper-Activation of PIK3CA in Keratin-15 + Stem Cells Lead to the Development of Spontaneous Squamous Cell Carcinoma.

  • Authors : Chen SMY; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.; Li B

Subjects: Genes, p53*; Carcinoma, Squamous Cell/Carcinoma, Squamous Cell/Carcinoma, Squamous Cell/*etiology ; Class I Phosphatidylinositol 3-Kinases/Class I Phosphatidylinositol 3-Kinases/Class I Phosphatidylinositol 3-Kinases/*metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2020 Sep 09; Vol. 21 (18). Date of Electronic Publication: 2020 Sep 09.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.

  • Authors : Zhao Q; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.; Zhu HP

Subjects: Class I Phosphatidylinositol 3-Kinases/Class I Phosphatidylinositol 3-Kinases/Class I Phosphatidylinositol 3-Kinases/*antagonists & inhibitors ; HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/*antagonists & inhibitors ; Melanoma/Melanoma/Melanoma/*drug therapy

  • Source: International journal of molecular sciences [Int J Mol Sci] 2020 Mar 07; Vol. 21 (5). Date of Electronic Publication: 2020 Mar 07.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Identification of Novel PI3Kδ Selective Inhibitors by SVM-Based Multistage Virtual Screening and Molecular Dynamics Simulations.

  • Authors : Liang JW; School of Pharmacy, China Medical University, Shenyang 110000, China.; Wang S

Subjects: Molecular Docking Simulation*; Class I Phosphatidylinositol 3-Kinases/Class I Phosphatidylinositol 3-Kinases/Class I Phosphatidylinositol 3-Kinases/*antagonists & inhibitors ; Protein Kinase Inhibitors/Protein Kinase Inhibitors/Protein Kinase Inhibitors/*pharmacology

  • Source: International journal of molecular sciences [Int J Mol Sci] 2019 Nov 28; Vol. 20 (23). Date of Electronic Publication: 2019 Nov 28.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Combined PIK3CA and SOX2 Gene Amplification Predicts Laryngeal Cancer Risk beyond Histopathological Grading.

  • Authors : Montoro-Jiménez I; Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias (IUOPA), University of Oviedo, 33011 Oviedo, Spain.; CIBERONC, Instituto de Salud Carlos III, 28029 Madrid, Spain.

Subjects: Laryngeal Neoplasms*/Laryngeal Neoplasms*/Laryngeal Neoplasms*/genetics ; Precancerous Conditions*/Precancerous Conditions*/Precancerous Conditions*/genetics; Humans

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 26; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 26.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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  • 1-10 ل  51 نتائج ل ""Class I Phosphatidylinositol 3-Kinases""