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Publication : international journal of molecular sciences

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Academic Journal

RBM17 Promotes the Chemoresistance of Oral Squamous Cancer Cells Through Checkpoint Kinase 1.

Authors : Nakahara, Miyuka¹ (AUTHOR); Arai, Ryosuke² (AUTHOR); Tokuoka, Isao^2,3 (AUTHOR)

Subjects: *Checkpoint kinase 1; *Head & neck cancer; *Ataxia telangiectasia mutated protein

Source: International Journal of Molecular Sciences. Apr2025, Vol. 26 Issue 7, p3127. 14p.

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Academic Journal

Antitumor Activity of Radiation Therapy Combined with Checkpoint Kinase Inhibition in SHH/ p53 -Mutated Human Medulloblastoma.

Authors : Kuchařová, Zuzana¹ (AUTHOR); Glasow, Annegret^1,2 (AUTHOR); Kortmann, Rolf-Dieter¹ (AUTHOR)

Subjects: *CHECKPOINT kinase 1; *DNA damage; *TUMOR growth

Source: International Journal of Molecular Sciences. Mar2025, Vol. 26 Issue 6, p2577. 17p.

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Academic Journal

Small-Molecule Mitotic Inhibitors as Anticancer Agents: Discovery, Classification, Mechanisms of Action, and Clinical Trials.

Authors : Salinas, Yazmin¹ (AUTHOR); Chauhan, Subhash C.^2,3 (AUTHOR); Bandyopadhyay, Debasish^1,3,4 (AUTHOR)

Subjects: *Microtubule-associated protein kinase; *Checkpoint kinase 1; *Antimitotic agents

Source: International Journal of Molecular Sciences. Apr2025, Vol. 26 Issue 7, p3279. 36p.

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Academic Journal

Checkpoint Kinase 1 Is a Key Signal Transducer of DNA Damage in the Early Mammalian Cleavage Embryo.

Authors : Baran, Vladimír¹ (AUTHOR) ; Mayer, Alexandra² (AUTHOR)

Subjects: *CHECKPOINT kinase 1; *MAMMALIAN embryos; *SOMATIC cells

Source: International Journal of Molecular Sciences. Apr2023, Vol. 24 Issue 7, p6778. 15p.

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Academic Journal

Spatio-Temporal Characterization of Cellular Senescence Hallmarks in Experimental Ischemic Stroke.

Authors : Baixauli-Martín, Júlia^1,2 (AUTHOR); Burguete, Maria Consuelo^1,2 (AUTHOR); López-Morales, Mikahela A.^1,3 (AUTHOR)

Subjects: *Checkpoint kinase 2; *Checkpoint kinase 1; *Ischemic stroke

Source: International Journal of Molecular Sciences. Mar2025, Vol. 26 Issue 5, p2364. 18p.

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Academic Journal

Targeting Metabolic and Epigenetic Vulnerabilities in Glioblastoma with SN-38 and Rabusertib Combination Therapy.

Authors : Chiou, Jennifer^1,2 (AUTHOR) ; Impedovo, Valeria^1,2 (AUTHOR) ; Huynh, Yen Bao^1,2 (AUTHOR)

Subjects: *CHECKPOINT kinase 1; *DNA ligases; *DNA topoisomerase inhibitors

Source: International Journal of Molecular Sciences. Jan2025, Vol. 26 Issue 2, p474. 17p.

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Academic Journal

MK-8776 and Olaparib Combination Acts Synergistically in Hepatocellular Carcinoma Cells, Demonstrating Lack of Adverse Effects on Liver Tissues in Ovarian Cancer PDX Model.

Authors : Bębenek, Wiktoria^1,2 (AUTHOR) ; Gajek, Arkadiusz¹ (AUTHOR) ; Marczak, Agnieszka¹ (AUTHOR)

Subjects: *CHECKPOINT kinase 1; *LIVER cancer; *HEPATOCELLULAR carcinoma

Source: International Journal of Molecular Sciences. Jan2025, Vol. 26 Issue 2, p834. 21p.

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Academic Journal

Interaction of DDB1 with NBS1 in a DNA Damage Checkpoint Pathway.

Authors : Lim HE; Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul 06351, Republic of Korea.; Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351, Republic of Korea.

Subjects: Cell Cycle Proteins*/Cell Cycle Proteins*/Cell Cycle Proteins*/metabolism ; Cell Cycle Proteins*/Cell Cycle Proteins*/Cell Cycle Proteins*/genetics ; DNA Damage*

Source: International journal of molecular sciences [Int J Mol Sci] 2024 Dec 05; Vol. 25 (23). Date of Electronic Publication: 2024 Dec 05.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Checkpoint Kinase 1 Pharmacological Inhibition Synergizes with DNA-Damaging Agents and Overcomes Platinum Resistance in Basal-Like Breast Cancer.

Authors : Nieto-Jimenez C; Translational Research Unit and CIBERONC, Albacete University Hospital, 02002 Albacete, Spain.; Translational Oncology Laboratory, Centro Regional de Investigaciones Biomédicas (CRIB) and Nursery School, Campus de Albacete, Universidad de Castilla-La Mancha, 02008 Albacete, Spain.

Subjects: DNA Damage*; Breast Neoplasms/Breast Neoplasms/Breast Neoplasms/*drug therapy ; Breast Neoplasms/Breast Neoplasms/Breast Neoplasms/*enzymology

Source: International journal of molecular sciences [Int J Mol Sci] 2020 Nov 27; Vol. 21 (23). Date of Electronic Publication: 2020 Nov 27.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Identification of CDK1, PBK, and CHEK1 as an Oncogenic Signature in Glioblastoma: A Bioinformatics Approach to Repurpose Dapagliflozin as a Therapeutic Agent.

Authors : Chinyama, Harold A.¹ (AUTHOR) ; Wei, Li^2,3,4 (AUTHOR) ; Mokgautsi, Ntlotlang^5,6 (AUTHOR)

Subjects: *CHECKPOINT kinase 1; *CYCLIN-dependent kinases; *PROTEIN kinases

Source: International Journal of Molecular Sciences. Nov2023, Vol. 24 Issue 22, p16396. 18p.

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