Authors : Lagathu C; INSERM, U680, Université Pierre et Marie Curie (UPMC-Paris 6), Faculty of Medicine, 27 rue Chaligny, 75012, Paris, France.; Yvan-Charvet L

Subjects: Insulin Resistance*; Adipocytes/Adipocytes/Adipocytes/*drug effects ; Interleukin-1beta/Interleukin-1beta/Interleukin-1beta/*pharmacology

Source: Diabetologia [Diabetologia] 2006 Sep; Vol. 49 (9), pp. 2162-73. Date of Electronic Publication: 2006 Jul 25.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Print ISSN:

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Academic Journal

Inhibition of MafA transcriptional activity and human insulin gene transcription by interleukin-1beta and mitogen-activated protein kinase kinase kinase in pancreatic islet beta cells.

Authors : Oetjen E; Department of Molecular Pharmacology, University of Göttingen, Robert-Koch-Strasse 40, 37099 Göttingen, Germany. ; Blume R

Subjects: Insulin/Insulin/Insulin/*genetics ; Insulin-Secreting Cells/Insulin-Secreting Cells/Insulin-Secreting Cells/*drug effects ; Interleukin-1beta/Interleukin-1beta/Interleukin-1beta/*pharmacology

Source: Diabetologia [Diabetologia] 2007 Aug; Vol. 50 (8), pp. 1678-87. Date of Electronic Publication: 2007 Jun 22.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Print ISSN:

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Academic Journal

Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro

Authors : Templin, Andrew T; Mellati, Mahnaz; Meier, Daniel T

Subjects: Public Health; Biomedical and Clinical Sciences; Clinical Sciences

Source: Diabetologia. 63(11)

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Academic Journal

Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells.

Authors : Ortis F; Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Route de Lennik, 808-CP-618, 1070, Brussels, Belgium, .; Pirot P

Subjects: Apoptosis/Apoptosis/Apoptosis/*physiology ; Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/*physiopathology ; Insulin-Secreting Cells/Insulin-Secreting Cells/Insulin-Secreting Cells/*physiology

Source: Diabetologia [Diabetologia] 2008 Jul; Vol. 51 (7), pp. 1213-25. Date of Electronic Publication: 2008 May 08.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Print ISSN:

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Academic Journal

Protection of rat pancreatic islets by potassium channel openers against alloxan, sodium nitroprusside and interleukin-1beta mediated suppression--possible involvement of the mitochondrial membrane potential.

Authors : Kullin M; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.; Li Z

Subjects: Alloxan/Alloxan/Alloxan/*pharmacology ; Diazoxide/Diazoxide/Diazoxide/*analogs & derivatives ; Diazoxide/Diazoxide/Diazoxide/*pharmacology

Source: Diabetologia [Diabetologia] 2003 Jan; Vol. 46 (1), pp. 80-8. Date of Electronic Publication: 2003 Jan 11.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Print ISSN:

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Academic Journal

Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction

Authors : Taylor-Fishwick, David A; Weaver, Jessica; Glenn, Lindsey

Subjects: Biomedical and Clinical Sciences; Clinical Sciences; Biotechnology

Source: Diabetologia. 58(3)

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Academic Journal

Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway.

Authors : Elshaer SL; Augusta Biomedical Research Corporation, Augusta, GA, USA.; Charlie Norwood VA Medical Center, Augusta, GA, USA.

Subjects: Capillary Permeability*; Diabetes Complications/Diabetes Complications/Diabetes Complications/*prevention & control ; Diabetic Retinopathy/Diabetic Retinopathy/Diabetic Retinopathy/*metabolism

Source: Diabetologia [Diabetologia] 2019 Aug; Vol. 62 (8), pp. 1488-1500. Date of Electronic Publication: 2019 May 09.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Distribution of IL-1β immunoreactive cells in pancreatic biopsies from living volunteers with new-onset type 1 diabetes: comparison with donors without diabetes and with longer duration of disease.

Authors : Reddy S; Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand. .; Krogvold L

Subjects: Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/*metabolism ; Interleukin-1beta/Interleukin-1beta/Interleukin-1beta/*metabolism ; Pancreas/Pancreas/Pancreas/*cytology

Source: Diabetologia [Diabetologia] 2018 Jun; Vol. 61 (6), pp. 1362-1373. Date of Electronic Publication: 2018 Mar 27.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes.

Authors : Lakhter AJ; Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, IN, USA.; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, 635 Barnhill Dr., Rm 2031, Indianapolis, IN, 46202, USA.

Subjects: Biomarkers/Biomarkers/Biomarkers/*metabolism ; Cytokines/Cytokines/Cytokines/*metabolism ; Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/*metabolism

Source: Diabetologia [Diabetologia] 2018 May; Vol. 61 (5), pp. 1124-1134. Date of Electronic Publication: 2018 Feb 14.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Oral histone deacetylase inhibitor synergises with T cell targeted immunotherapy to preserve beta cell metabolic function and induce stable remission of new-onset autoimmune diabetes in NOD mice.

Authors : Besançon A; University Paris Descartes, Sorbonne Paris Cité, Paris, France.; INSERM U1151, Institut Necker-Enfants Malades, Hôpital Necker, Bâtiment Hamburger, 5ème étage, 149 rue de Sèvres, 75015, Paris, France.

Subjects: Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/*drug therapy ; Histone Deacetylase Inhibitors/Histone Deacetylase Inhibitors/Histone Deacetylase Inhibitors/*therapeutic use ; Immunotherapy/Immunotherapy/Immunotherapy/*methods

Source: Diabetologia [Diabetologia] 2018 Feb; Vol. 61 (2), pp. 389-398. Date of Electronic Publication: 2017 Oct 13.Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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نتائج البحث

فلترة النتائج

Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes.

Inhibition of MafA transcriptional activity and human insulin gene transcription by interleukin-1beta and mitogen-activated protein kinase kinase kinase in pancreatic islet beta cells.

Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro

Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells.

Protection of rat pancreatic islets by potassium channel openers against alloxan, sodium nitroprusside and interleukin-1beta mediated suppression--possible involvement of the mitochondrial membrane potential.

Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction

Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway.

Distribution of IL-1β immunoreactive cells in pancreatic biopsies from living volunteers with new-onset type 1 diabetes: comparison with donors without diabetes and with longer duration of disease.

Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes.

Oral histone deacetylase inhibitor synergises with T cell targeted immunotherapy to preserve beta cell metabolic function and induce stable remission of new-onset autoimmune diabetes in NOD mice.

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