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Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase.

• Authors : Qiao H; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, 200032, Shanghai, China.; Wang Z

Subjects: Threonine-tRNA Ligase*/Threonine-tRNA Ligase*/Threonine-tRNA Ligase*/metabolism ; Threonine-tRNA Ligase*/Threonine-tRNA Ligase*/Threonine-tRNA Ligase*/chemistry ; Threonine-tRNA Ligase*/Threonine-tRNA Ligase*/Threonine-tRNA Ligase*/genetics

• Source: Communications biology [Commun Biol] 2024 Jul 16; Vol. 7 (1), pp. 867. Date of Electronic Publication: 2024 Jul 16.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors.

• Authors : Zhou J; School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 1 Sub-lane Xiangshan, Hangzhou, 310024, China.; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.

Subjects: Plasmodium falciparum*/Plasmodium falciparum*/Plasmodium falciparum*/enzymology ; Plasmodium falciparum*/Plasmodium falciparum*/Plasmodium falciparum*/drug effects ; Lysine-tRNA Ligase*/Lysine-tRNA Ligase*/Lysine-tRNA Ligase*/antagonists & inhibitors

• Source: Communications biology [Commun Biol] 2024 Jun 18; Vol. 7 (1), pp. 742. Date of Electronic Publication: 2024 Jun 18.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Targeting alveolar epithelial cells with lipid micelle-encapsulated necroptosis inhibitors to alleviate acute lung injury.

• Authors : Kang, Zhi-ying¹ (AUTHOR); Xuan, Nan-xia¹ (AUTHOR); Zhou, Qi-chao¹ (AUTHOR)

• Source: Communications Biology. 4/4/2025, Vol. 8 Issue 1, p1-16. 16p.

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Development of chemokine network inhibitors using combinatorial saturation mutagenesis.

• Authors : Kryukova, Jhanna¹ (AUTHOR); Vales, Serena¹ (AUTHOR); Payne, Megan¹ (AUTHOR)

• Source: Communications Biology. 4/3/2025, Vol. 8 Issue 1, p1-17. 17p.

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Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens.

• Authors : Fenwick MK; Seattle Structural Genomics Center for Infectious Disease, 307 Westlake Avenue North, Seattle, WA, 98109, USA.; Center for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Avenue North, Seattle, WA, 98109, USA.

Subjects: DNA Polymerase III*/DNA Polymerase III*/DNA Polymerase III*/metabolism ; DNA Polymerase III*/DNA Polymerase III*/DNA Polymerase III*/chemistry ; DNA Polymerase III*/DNA Polymerase III*/DNA Polymerase III*/antagonists & inhibitors

• Source: Communications biology [Commun Biol] 2024 Dec 05; Vol. 7 (1), pp. 1622. Date of Electronic Publication: 2024 Dec 05.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Ibetazol, a novel inhibitor of importin β1-mediated nuclear import.

• Authors : Vercruysse T; KU Leuven Department of Microbiology, Immunology and Transplantation, Molecular Genetics and Therapeutics in Virology and Oncology Research Group, Rega Institute, Leuven, Belgium.; Astrivax NV, Heverlee, Belgium.

Subjects: beta Karyopherins*/beta Karyopherins*/beta Karyopherins*/metabolism ; beta Karyopherins*/beta Karyopherins*/beta Karyopherins*/antagonists & inhibitors ; Active Transport, Cell Nucleus*/Active Transport, Cell Nucleus*/Active Transport, Cell Nucleus*/drug effects

• Source: Communications biology [Commun Biol] 2024 Nov 23; Vol. 7 (1), pp. 1560. Date of Electronic Publication: 2024 Nov 23.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Repurposing of phosphodiesterase-5 inhibitor sildenafil as a therapeutic agent to prevent gastric cancer growth through suppressing c-MYC stability for IL-6 transcription.

• Authors : Zhang, Zhenzhan¹ (AUTHOR); Huang, Wuqing² (AUTHOR); Huang, Donghua³ (AUTHOR)

• Source: Communications Biology. 1/18/2025, Vol. 8 Issue 1, p1-14. 14p.

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Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay

• Authors : Narayanan, Anoop; Narwal, Manju; Majowicz, Sydney A

Subjects: Infectious Diseases; Lung; Pneumonia

• Source: Communications Biology. 5(1)

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The small molecule ML233 is a direct inhibitor of tyrosinase function.

• Authors : Menard R; MDI Biological Laboratory, Kathryn W. Davis Center for Regenerative Biology and Aging, Bar Harbor, ME, USA.; Baanannou A

Subjects: Monophenol Monooxygenase*/Monophenol Monooxygenase*/Monophenol Monooxygenase*/antagonists & inhibitors ; Monophenol Monooxygenase*/Monophenol Monooxygenase*/Monophenol Monooxygenase*/metabolism ; Zebrafish*

• Source: Communications biology [Commun Biol] 2025 Mar 28; Vol. 8 (1), pp. 506. Date of Electronic Publication: 2025 Mar 28.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Unmodified RNA sequences form unusual stable G-quadruplexes with potential anti-RSV and anti-angiogenesis applications.

• Authors : Tian RQ; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, PR China.; The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province and The High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Druggability, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, PR China.

Subjects: G-Quadruplexes* ; Angiogenesis Inhibitors*/Angiogenesis Inhibitors*/Angiogenesis Inhibitors*/pharmacology ; Angiogenesis Inhibitors*/Angiogenesis Inhibitors*/Angiogenesis Inhibitors*/chemistry

• Source: Communications biology [Commun Biol] 2025 Mar 21; Vol. 8 (1), pp. 474. Date of Electronic Publication: 2025 Mar 21.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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