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Academic Journal

Quantitative systems pharmacology modeling of macrophage-targeted therapy combined with PD-L1 inhibition in advanced NSCLC.

Authors : Wang H; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Arulraj T

Subjects: Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/drug therapy ; Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/pathology ; Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/immunology

Source: Clinical and translational science [Clin Transl Sci] 2024 Jun; Vol. 17 (6), pp. e13811.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Using electronic health records for clinical pharmacology research: Challenges and considerations.

Authors : Jafari E; Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA.; Department of Pharmacy Practice, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.

Subjects: Electronic Health Records*/Electronic Health Records*/Electronic Health Records*/statistics & numerical data ; Pharmacology, Clinical*/Pharmacology, Clinical*/Pharmacology, Clinical*/methods; Humans

Source: Clinical and translational science [Clin Transl Sci] 2024 Jul; Vol. 17 (7), pp. e13871.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Advancing the utilization of real-world data and real-world evidence in clinical pharmacology and translational research-Proceedings from the ASCPT 2023 preconference workshop.

Authors : Liu J; Pfizer Inc., Groton, Connecticut, USA.; Rowland-Yeo K

Subjects: Pharmacology, Clinical*; Humans ; Translational Research, Biomedical

Source: Clinical and translational science [Clin Transl Sci] 2024 Apr; Vol. 17 (4), pp. e13785.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Sources of pharmacokinetic and pharmacodynamic variability and clinical pharmacology studies of antiseizure medications in the pediatric population.

Authors : Maglalang PD; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Wen J

Subjects: Pharmacology, Clinical* ; Epilepsy*/Epilepsy*/Epilepsy*/drug therapy; United States

Source: Clinical and translational science [Clin Transl Sci] 2024 Apr; Vol. 17 (4), pp. e13793.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Evaluation of drug-drug interactions of a novel potent FLT3 inhibitor SKLB1028 in healthy subjects.

Authors : Chen J; Beijing Friendship Hospital, Capital Medical University, Beijing, China.; Wu J

Subjects: Drug Interactions* ; fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/antagonists & inhibitors ; fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/metabolism

Source: Clinical and translational science [Clin Transl Sci] 2024 Nov; Vol. 17 (11), pp. e70063.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Imetelstat, a novel, first-in-class telomerase inhibitor: Mechanism of action, clinical, and translational science.

Authors : Lennox AL; Geron Corporation, Foster City, CA, USA.; Huang F

Subjects: Telomerase*/Telomerase*/Telomerase*/antagonists & inhibitors ; Telomerase*/Telomerase*/Telomerase*/metabolism ; Translational Research, Biomedical*

Source: Clinical and translational science [Clin Transl Sci] 2024 Nov; Vol. 17 (11), pp. e70076.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Asia-inclusive drug development leveraging principles of ICH E5 and E17 guidelines: Case studies illustrating quantitative clinical pharmacology as a foundational enabler.

Authors : Lu H; Merck Serono (Beijing) Pharmaceutical R&D Co., Ltd., Beijing, China.; Klopp-Schulze L

Subjects: Drug Development*/Drug Development*/Drug Development*/methods; Humans ; Asia

Source: Clinical and translational science [Clin Transl Sci] 2024 Oct; Vol. 17 (10), pp. e70050.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Increased coproporphyrin serum levels in healthy volunteers treated with the cholesterol uptake inhibitor ezetimibe.

Authors : Kinzi J; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.; Grube M

Subjects: Ezetimibe*/Ezetimibe*/Ezetimibe*/administration & dosage ; Ezetimibe*/Ezetimibe*/Ezetimibe*/pharmacology ; Ezetimibe*/Ezetimibe*/Ezetimibe*/pharmacokinetics

Source: Clinical and translational science [Clin Transl Sci] 2024 Oct; Vol. 17 (10), pp. e70041.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Examining the effects of the HIV-1 protein Tat and morphine on antiretroviral accumulation and distribution within the brain.

Authors : Jones AM; Department of Pharmacotherapy and Outcomes Science, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia, USA.; Rademeyer KM

Subjects: Brain*/Brain*/Brain*/metabolism ; Brain*/Brain*/Brain*/drug effects ; Brain*/Brain*/Brain*/diagnostic imaging

Source: Clinical and translational science [Clin Transl Sci] 2024 Oct; Vol. 17 (10), pp. e70035.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Safety, pharmacokinetics, and pharmacodynamics of sofnobrutinib, a novel non-covalent BTK inhibitor, in healthy subjects: First-in-human phase I study.

Authors : Miyamoto K; CarnaBio USA, Inc., South San Francisco, California, USA.; Miller RM

Subjects: Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/antagonists & inhibitors ; Healthy Volunteers* ; Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/pharmacokinetics

Source: Clinical and translational science [Clin Transl Sci] 2024 Nov; Vol. 17 (11), pp. e70060.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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نتائج البحث

فلترة النتائج

Quantitative systems pharmacology modeling of macrophage-targeted therapy combined with PD-L1 inhibition in advanced NSCLC.

Using electronic health records for clinical pharmacology research: Challenges and considerations.

Advancing the utilization of real-world data and real-world evidence in clinical pharmacology and translational research-Proceedings from the ASCPT 2023 preconference workshop.

Sources of pharmacokinetic and pharmacodynamic variability and clinical pharmacology studies of antiseizure medications in the pediatric population.

Evaluation of drug-drug interactions of a novel potent FLT3 inhibitor SKLB1028 in healthy subjects.

Imetelstat, a novel, first-in-class telomerase inhibitor: Mechanism of action, clinical, and translational science.

Asia-inclusive drug development leveraging principles of ICH E5 and E17 guidelines: Case studies illustrating quantitative clinical pharmacology as a foundational enabler.

Increased coproporphyrin serum levels in healthy volunteers treated with the cholesterol uptake inhibitor ezetimibe.

Examining the effects of the HIV-1 protein Tat and morphine on antiretroviral accumulation and distribution within the brain.

Safety, pharmacokinetics, and pharmacodynamics of sofnobrutinib, a novel non-covalent BTK inhibitor, in healthy subjects: First-in-human phase I study.

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