Authors : Badorrek P; Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany.; Diefenbach C

Subjects: Bronchiectasis*/Bronchiectasis*/Bronchiectasis*/drug therapy ; Cathepsin C*/Cathepsin C*/Cathepsin C*/antagonists & inhibitors ; Cathepsin C*/Cathepsin C*/Cathepsin C*/metabolism

Source: Clinical and translational science [Clin Transl Sci] 2024 Aug; Vol. 17 (8), pp. e13891.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

First-in-human study evaluating safety, pharmacokinetics, and pharmacodynamics of lorundrostat, a novel and highly selective aldosterone synthase inhibitor.

Authors : Shimizu H; Clinical Pharmacology Group, Data Science Department, Ikuyaku, Integrated Value Development Division, Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan.; Tortorici MA

Subjects: Cytochrome P-450 CYP11B2*/Cytochrome P-450 CYP11B2*/Cytochrome P-450 CYP11B2*/antagonists & inhibitors ; Aldosterone*/Aldosterone*/Aldosterone*/blood ; Dose-Response Relationship, Drug*

Source: Clinical and translational science [Clin Transl Sci] 2024 Aug; Vol. 17 (8), pp. e70000.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Using exploratory pharmacokinetic and pharmacodynamic analyses to predict the probability of flu-like symptoms in healthy volunteers and patients with chronic hepatitis B treated with the toll-like receptor 7 agonist ruzotolimod.

Authors : Jiang Q; Roche Innovation Center, Shanghai, China.; Zhang Y

Subjects: Toll-Like Receptor 7*/Toll-Like Receptor 7*/Toll-Like Receptor 7*/agonists ; Healthy Volunteers* ; Hepatitis B, Chronic*/Hepatitis B, Chronic*/Hepatitis B, Chronic*/drug therapy

Source: Clinical and translational science [Clin Transl Sci] 2024 Aug; Vol. 17 (8), pp. e13896.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Dalzanemdor (SAGE-718), a novel, investigational N-methyl-D-aspartate receptor positive allosteric modulator: Safety, tolerability, and clinical pharmacology in randomized dose-finding studies in healthy participants and an open-label study in participants with Huntington's disease.

Authors : Koenig A; Sage Therapeutics, Inc, Cambridge, Massachusetts, USA.; Lewis M

Subjects: Huntington Disease*/Huntington Disease*/Huntington Disease*/drug therapy ; Receptors, N-Methyl-D-Aspartate*/Receptors, N-Methyl-D-Aspartate*/Receptors, N-Methyl-D-Aspartate*/antagonists & inhibitors ; Dose-Response Relationship, Drug*

Source: Clinical and translational science [Clin Transl Sci] 2024 Jul; Vol. 17 (7), pp. e13852.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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A phase I thorough QT/QTc study evaluating therapeutic and supratherapeutic doses of avacopan in healthy participants.

Authors : Miao S; Amgen Inc., Thousand Oaks, California, USA.; Staehr P

Subjects: Electrocardiography* ; Healthy Volunteers* ; Cross-Over Studies*

Source: Clinical and translational science [Clin Transl Sci] 2024 Jul; Vol. 17 (7), pp. e13878.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

A phase I randomized study to evaluate safety, pharmacokinetics, and pharmacodynamics of SIR2446M, a selective RIPK1 inhibitor, in healthy participants.

Authors : Sun ALA; Linear Clinical Research Limited, Nedlands, Western Australia, Australia.; Gillies JD

Subjects: Healthy Volunteers* ; Receptor-Interacting Protein Serine-Threonine Kinases*/Receptor-Interacting Protein Serine-Threonine Kinases*/Receptor-Interacting Protein Serine-Threonine Kinases*/antagonists & inhibitors ; Receptor-Interacting Protein Serine-Threonine Kinases*/Receptor-Interacting Protein Serine-Threonine Kinases*/Receptor-Interacting Protein Serine-Threonine Kinases*/metabolism

Source: Clinical and translational science [Clin Transl Sci] 2024 Jul; Vol. 17 (7), pp. e13857.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Age-related off-label drug prescribing in pediatric patients in South Korea and consistency of labeling compared to the United States, Europe, and Japan.

Authors : Park B; School of Pharmacy, Sungkyunkwan University, Suwon, South Korea.; Lee H

Subjects: Off-Label Use*/Off-Label Use*/Off-Label Use*/statistics & numerical data ; Drug Labeling*/Drug Labeling*/Drug Labeling*/standards ; Drug Labeling*/Drug Labeling*/Drug Labeling*/statistics & numerical data

Source: Clinical and translational science [Clin Transl Sci] 2024 Jul; Vol. 17 (7), pp. e13869.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Utility of the 13C-pantoprazole breath test as a CYP2C19 phenotyping probe for children

Authors : Feldman K.; Kearns G.L.; Pearce R.E.

Subjects: cytochrome P450 2C19; drug metabolite; pantoprazole

Source: Clinical and Translational Science

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نتائج البحث

فلترة النتائج

Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics

Population Pharmacokinetics of Metoclopramide in Infants, Children, and Adolescents

Novel cathepsin C inhibitor, BI 1291583, intended for treatment of bronchiectasis: Phase I characterization in healthy volunteers.

First-in-human study evaluating safety, pharmacokinetics, and pharmacodynamics of lorundrostat, a novel and highly selective aldosterone synthase inhibitor.

Using exploratory pharmacokinetic and pharmacodynamic analyses to predict the probability of flu-like symptoms in healthy volunteers and patients with chronic hepatitis B treated with the toll-like receptor 7 agonist ruzotolimod.

Dalzanemdor (SAGE-718), a novel, investigational N-methyl-D-aspartate receptor positive allosteric modulator: Safety, tolerability, and clinical pharmacology in randomized dose-finding studies in healthy participants and an open-label study in participants with Huntington's disease.

A phase I thorough QT/QTc study evaluating therapeutic and supratherapeutic doses of avacopan in healthy participants.

A phase I randomized study to evaluate safety, pharmacokinetics, and pharmacodynamics of SIR2446M, a selective RIPK1 inhibitor, in healthy participants.

Age-related off-label drug prescribing in pediatric patients in South Korea and consistency of labeling compared to the United States, Europe, and Japan.

Utility of the 13C-pantoprazole breath test as a CYP2C19 phenotyping probe for children

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