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The antiarrhythmic compound efsevin directly modulates voltage-dependent anion channel 2 by binding to its inner wall and enhancing mitochondrial Ca 2+ uptake.

• Authors : Wilting F; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, Munich, Germany.; Kopp R

Subjects: Mitochondria*/Mitochondria*/Mitochondria*/metabolism ; Voltage-Dependent Anion Channel 2*/Voltage-Dependent Anion Channel 2*/Voltage-Dependent Anion Channel 2*/agonists ; Voltage-Dependent Anion Channel 2*/Voltage-Dependent Anion Channel 2*/Voltage-Dependent Anion Channel 2*/metabolism

• Source: British journal of pharmacology [Br J Pharmacol] 2020 Jul; Vol. 177 (13), pp. 2947-2958. Date of Electronic Publication: 2020 Mar 25.Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381

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