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Academic Journal

Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells.

  • Authors : García-Santisteban I; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), B/Sarriena s/n, 48940, Leioa, Basque Country, Spain.; Oncode Institute, Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.

Subjects: DNA Damage*; Ataxia Telangiectasia Mutated Proteins/Ataxia Telangiectasia Mutated Proteins/Ataxia Telangiectasia Mutated Proteins/*genetics ; Checkpoint Kinase 2/Checkpoint Kinase 2/Checkpoint Kinase 2/*genetics

  • Source: BMC biology [BMC Biol] 2021 Feb 19; Vol. 19 (1), pp. 35. Date of Electronic Publication: 2021 Feb 19.Publisher: BioMed Central Country of Publication: England NLM ID: 101190720 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7007

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Academic Journal

Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restriction.

  • Authors : Clementi E; Institute of Veterinary Pharmacology and Toxicology, Vetsuisse Faculty, University of Zürich, 8057, Zürich, Switzerland.; Inglin L

Subjects: DNA Damage* ; DNA Repair*; Nutrients/Nutrients/Nutrients/*deficiency

  • Source: BMC biology [BMC Biol] 2020 Mar 30; Vol. 18 (1), pp. 36. Date of Electronic Publication: 2020 Mar 30.Publisher: BioMed Central Country of Publication: England NLM ID: 101190720 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7007

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Academic Journal

The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage.

  • Authors : Sabouri N; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, 901 87, Sweden. .; Capra JA

Subjects: DNA Damage* ; G-Quadruplexes* ; Protein Structure, Tertiary*

  • Source: BMC biology [BMC Biol] 2014 Dec 04; Vol. 12, pp. 101. Date of Electronic Publication: 2014 Dec 04.Publisher: BioMed Central Country of Publication: England NLM ID: 101190720 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7007

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