Authors : Thirugnanasambandham I; Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Nilgiris, Tamil Nadu, India.; Jupudi S

Subjects: Arthritis, Rheumatoid*/Arthritis, Rheumatoid*/Arthritis, Rheumatoid*/drug therapy ; Arthritis, Rheumatoid*/Arthritis, Rheumatoid*/Arthritis, Rheumatoid*/enzymology ; Protein-Arginine Deiminase Type 4*/Protein-Arginine Deiminase Type 4*/Protein-Arginine Deiminase Type 4*/antagonists & inhibitors

Source: The Biochemical journal [Biochem J] 2024 Oct 16; Vol. 481 (20), pp. 1379-1393.Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited

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Academic Journal

Permeation mechanisms of hydrogen peroxide and water through Plasma Membrane Intrinsic Protein aquaporins.

Authors : Chevriau J; Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química y Fisicoquímica Biológica (IQUIFIB), Buenos Aires, Argentina.; De Palma GZ

Subjects: Hydrogen Peroxide*/Hydrogen Peroxide*/Hydrogen Peroxide*/metabolism ; Aquaporins*/Aquaporins*/Aquaporins*/metabolism ; Aquaporins*/Aquaporins*/Aquaporins*/chemistry

Source: The Biochemical journal [Biochem J] 2024 Oct 02; Vol. 481 (19), pp. 1329-1347.Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited

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Molecular insights of inhibition in sickle hemoglobin polymerization upon glutathionylation: hydrogen/deuterium exchange mass spectrometry and molecular dynamics simulation-based approach

Authors : Rajdeep Das; Amrita Mitra; Gopa Mitra

Subjects: 0303 health sciences; 03 medical and health sciences; Hemoglobin, Sickle

Source: Biochemical Journal. 475:2153-2166

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Molecular insights of inhibition in sickle hemoglobin polymerization upon glutathionylation: hydrogen/deuterium exchange mass spectrometry and molecular dynamics simulation-based approach.

Authors : Das, Rajdeep¹; Mitra, Amrita¹; Mitra, Gopa¹

Subjects: *Sickle cell anemia; *Polymerization; *Hemoglobins

Source: Biochemical Journal. 7/16/2018, Vol. 475 Issue 13, p2153-2166. 14p.

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Probing the importance of hydrogen bonds in the active site of the subtilisin nattokinase by site-directed mutagenesis and molecular dynamics simulation

Authors : Mao-qing Ye; Zhong-liang Zheng; Keng-chang Tai

Subjects: Models, Molecular; 0301 basic medicine; Binding Sites

Source: Biochemical Journal. 395:509-515

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Design of an adenosine phosphorylase by active-site modification of murine purine nucleoside phosphorylase: Enzyme kinetics and molecular dynamics simulation of Asn-243 and Lys-244 substitutions of purine nucleoside phosphorylase

Authors : R. Gang Yuan; Steven A. Litster; Jack P. Jenuth

Subjects: Models, Molecular; Aspartic Acid; 0303 health sciences

Source: Biochemical Journal. 344:585-592

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Enhanced plant-microbe remediation of PCBs in soil using enzyme modification technique combined with molecular docking and molecular dynamics.

Authors : Li M; He W; Li Y

Subjects: Biodegradation, Environmental* ; Molecular Docking Simulation* ; Molecular Dynamics Simulation*

Source: The Biochemical journal [Biochem J] 2021 May 28; Vol. 478 (10), pp. 1921-1941.Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited

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Comparative analysis of canine and human HtrA2 to delineate its role in apoptosis and cancer.

Authors : Mudrale SP; Integrated Biophysics and Structural Biology Lab, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Mumbai 410210, India.; Dutta S

Subjects: High-Temperature Requirement A Serine Peptidase 2*/High-Temperature Requirement A Serine Peptidase 2*/High-Temperature Requirement A Serine Peptidase 2*/metabolism ; High-Temperature Requirement A Serine Peptidase 2*/High-Temperature Requirement A Serine Peptidase 2*/High-Temperature Requirement A Serine Peptidase 2*/genetics ; Apoptosis*

Source: The Biochemical journal [Biochem J] 2024 Nov 20; Vol. 481 (22), pp. 1603-1620.Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited

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Demonstration that 1-trans-epoxysuccinyl-l-leucylamido-(4-guanidino) butane (E-64) is one of the most effective low Mr inhibitors of trypsin-catalysed hydrolysis. Characterization by kinetic analysis and by energy minimization and molecular dynamics simulation of the E-64-β-trypsin complex

Authors : Keith Brocklehurst; Leo S. D. Caves; Suneal K. Sreedharan

Subjects: Models, Molecular; 0301 basic medicine; Molecular Structure

Source: Biochemical Journal. 316:777-786

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Molecular dynamics simulations and biochemical characterization of Pf14-3-3 and PfCDPK1 interaction towards its role in growth of human malaria parasite.

Authors : Jain R; Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Gautam Buddha Nagar, UP 201314, India.; Dey P

Subjects: Molecular Dynamics Simulation*; 14-3-3 Proteins/14-3-3 Proteins/14-3-3 Proteins/*metabolism ; Malaria, Falciparum/Malaria, Falciparum/Malaria, Falciparum/*parasitology

Source: The Biochemical journal [Biochem J] 2020 Jun 26; Vol. 477 (12), pp. 2153-2177.Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited

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نتائج البحث

فلترة النتائج

Revamped role for approved drug: integrative computational and biophysical analysis of saquinavir's peptidyl arginine deiminase 4 inhibition for rheumatoid arthritis.

Permeation mechanisms of hydrogen peroxide and water through Plasma Membrane Intrinsic Protein aquaporins.

Molecular insights of inhibition in sickle hemoglobin polymerization upon glutathionylation: hydrogen/deuterium exchange mass spectrometry and molecular dynamics simulation-based approach

Molecular insights of inhibition in sickle hemoglobin polymerization upon glutathionylation: hydrogen/deuterium exchange mass spectrometry and molecular dynamics simulation-based approach.

Probing the importance of hydrogen bonds in the active site of the subtilisin nattokinase by site-directed mutagenesis and molecular dynamics simulation

Design of an adenosine phosphorylase by active-site modification of murine purine nucleoside phosphorylase: Enzyme kinetics and molecular dynamics simulation of Asn-243 and Lys-244 substitutions of purine nucleoside phosphorylase

Enhanced plant-microbe remediation of PCBs in soil using enzyme modification technique combined with molecular docking and molecular dynamics.

Comparative analysis of canine and human HtrA2 to delineate its role in apoptosis and cancer.

Demonstration that 1-trans-epoxysuccinyl-l-leucylamido-(4-guanidino) butane (E-64) is one of the most effective low Mr inhibitors of trypsin-catalysed hydrolysis. Characterization by kinetic analysis and by energy minimization and molecular dynamics simulation of the E-64-β-trypsin complex

Molecular dynamics simulations and biochemical characterization of Pf14-3-3 and PfCDPK1 interaction towards its role in growth of human malaria parasite.

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