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Academic Journal

Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.

  • Authors : Tolosa L; Unidad de Hepatología Experimental, Torre A, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Av Fernando Abril Martorell 106, 46026, Valencia, Spain. .; Jiménez N

Subjects: Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/*etiology ; Cytochrome P450 Family 2/Cytochrome P450 Family 2/Cytochrome P450 Family 2/*genetics ; Drug Evaluation, Preclinical/Drug Evaluation, Preclinical/Drug Evaluation, Preclinical/*methods

  • Source: Archives of toxicology [Arch Toxicol] 2018 Jan; Vol. 92 (1), pp. 383-399. Date of Electronic Publication: 2017 Jul 31.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

CYP35 family in Caenorhabditis elegans biological processes: fatty acid synthesis, xenobiotic metabolism, and stress responses.

  • Authors : Lim SYM; Division of Biomedical Sciences, School of Pharmacy, University of Nottingham Malaysia, 43500, Semenyih, Malaysia. .; Alshagga M

Subjects: Caenorhabditis elegans Proteins*/Caenorhabditis elegans Proteins*/Caenorhabditis elegans Proteins*/genetics ; Polycyclic Aromatic Hydrocarbons* ; Biological Phenomena*

  • Source: Archives of toxicology [Arch Toxicol] 2022 Dec; Vol. 96 (12), pp. 3163-3174. Date of Electronic Publication: 2022 Sep 29.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Sex-dependent dynamics of metabolism in primary mouse hepatocytes.

  • Authors : Hochmuth L; Faculty of Medicine, Rudolf-Schönheimer-Institute of Biochemistry, Leipzig University, Leipzig, Germany.; Körner C

Subjects: Hepatocytes/Hepatocytes/Hepatocytes/*metabolism ; Metabolome/Metabolome/Metabolome/*physiology ; Proteome/Proteome/Proteome/*physiology

  • Source: Archives of toxicology [Arch Toxicol] 2021 Sep; Vol. 95 (9), pp. 3001-3013. Date of Electronic Publication: 2021 Jul 09.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Constitutive androstane receptor (CAR) mediates dieldrin-induced liver tumorigenesis in mouse.

  • Authors : Wang Z; Laboratory of Investigative Toxicology and Pathology, Department of Environmental Health, Indiana University School of Public Health, 1025 E 7th St, Bloomington, IN, 47405, USA.; Wu Q

Subjects: Cell Transformation, Neoplastic/Cell Transformation, Neoplastic/Cell Transformation, Neoplastic/*chemically induced ; Dieldrin/Dieldrin/Dieldrin/*toxicity ; Insecticides/Insecticides/Insecticides/*toxicity

  • Source: Archives of toxicology [Arch Toxicol] 2020 Aug; Vol. 94 (8), pp. 2873-2884. Date of Electronic Publication: 2020 May 20.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

2,4-Dimethylaniline generates phosphorylated histone H2AX in human urothelial and hepatic cells through reactive oxygen species produced by cytochrome P450 2E1.

  • Authors : Qi Y; Industrial Toxicology and Health Effects Research Group, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki, Kanagawa, 214-8585, Japan.; Department of Environmental, Occupational Health and Toxicology, Graduate School of Medical Sciences, Kitasato University, Tokyo, Japan.

Subjects: Aniline Compounds/Aniline Compounds/Aniline Compounds/*toxicity ; Cytochrome P450 Family 2/Cytochrome P450 Family 2/Cytochrome P450 Family 2/*metabolism ; Hepatocytes/Hepatocytes/Hepatocytes/*drug effects

  • Source: Archives of toxicology [Arch Toxicol] 2018 Oct; Vol. 92 (10), pp. 3093-3101. Date of Electronic Publication: 2018 Aug 21.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Association between polymorphism of GSTP1, GSTT1, GSTM1 and CYP2E1 genes and susceptibility to benzene-induced hematotoxicity.

  • Authors : Nourozi MA; Department of Occupational Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.; Neghab M

Subjects: Genetic Predisposition to Disease* ; Polymorphism, Restriction Fragment Length*; Air Pollutants, Occupational/Air Pollutants, Occupational/Air Pollutants, Occupational/*toxicity

  • Source: Archives of toxicology [Arch Toxicol] 2018 Jun; Vol. 92 (6), pp. 1983-1990. Date of Electronic Publication: 2017 Dec 04.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid.

  • Authors : Abe T; Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-ku, Sendai, 980-8578, Japan.; Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.

Subjects: Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/*metabolism ; Caprylates/Caprylates/Caprylates/*toxicity ; Cytochrome P450 Family 2/Cytochrome P450 Family 2/Cytochrome P450 Family 2/*metabolism

  • Source: Archives of toxicology [Arch Toxicol] 2017 Jun; Vol. 91 (6), pp. 2365-2374. Date of Electronic Publication: 2016 Nov 10.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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