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The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling.

• Authors : Shang, Peng^1,2; Valapala, Mallika²; Grebe, Rhonda²

• Source: Aging Cell. Apr2017, Vol. 16 Issue 2, p349-359. 11p.

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The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling

• Authors : Lixia Lu; Guo-Tong Xu; Rhonda Grebe

Subjects: visual cycle proteins; 0301 basic medicine; Aging

• Source: Aging Cell

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Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan.

• Authors : Shetty M; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USA.; Noguchi C

Subjects: Gene Expression Regulation, Fungal*; Genomic Instability/Genomic Instability/Genomic Instability/*genetics ; Mechanistic Target of Rapamycin Complex 1/Mechanistic Target of Rapamycin Complex 1/Mechanistic Target of Rapamycin Complex 1/*metabolism

• Source: Aging cell [Aging Cell] 2020 Feb; Vol. 19 (2), pp. e13068. Date of Electronic Publication: 2019 Dec 12.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.

• Authors : Tang H; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California.

Subjects: Oxidative Stress*; Aging/Aging/Aging/*metabolism ; Mechanistic Target of Rapamycin Complex 1/Mechanistic Target of Rapamycin Complex 1/Mechanistic Target of Rapamycin Complex 1/*metabolism

• Source: Aging cell [Aging Cell] 2019 Jun; Vol. 18 (3), pp. e12943. Date of Electronic Publication: 2019 Mar 29.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Unbiased evaluation of rapamycin's specificity as an mTOR inhibitor.

• Authors : Artoni F; Max Planck Institute for Biology of Ageing (MPI-AGE), Cologne, Germany.; Cologne Graduate School of Ageing Research (CGA), Cologne, Germany.

Subjects: MTOR Inhibitors* ; Signal Transduction*; Mice

• Source: Aging cell [Aging Cell] 2023 Aug; Vol. 22 (8), pp. e13888. Date of Electronic Publication: 2023 May 24.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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The valosin-containing protein is a novel repressor of cardiomyocyte hypertrophy induced by pressure overload.

• Authors : Zhou N; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Division of Physiology, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, USA.

Subjects: Cardiomegaly/Cardiomegaly/Cardiomegaly/*genetics ; Cerebrovascular Disorders/Cerebrovascular Disorders/Cerebrovascular Disorders/*genetics ; Hypertension/Hypertension/Hypertension/*genetics

• Source: Aging cell [Aging Cell] 2017 Oct; Vol. 16 (5), pp. 1168-1179. Date of Electronic Publication: 2017 Aug 11.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration.

• Authors : Ryan KC; Department of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, New York, USA.; Ashkavand Z

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*genetics ; Caenorhabditis elegans/Caenorhabditis elegans/Caenorhabditis elegans/*genetics ; Caenorhabditis elegans Proteins/Caenorhabditis elegans Proteins/Caenorhabditis elegans Proteins/*metabolism

• Source: Aging cell [Aging Cell] 2021 Oct; Vol. 20 (10), pp. e13472. Date of Electronic Publication: 2021 Sep 09.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury.

• Authors : Lee HJ; Department of Medicine, Center for Renal Precision Medicine, University of Texas Health, San Antonio, TX, USA.; Donati A

Subjects: Acute Kidney Injury/Acute Kidney Injury/Acute Kidney Injury/*drug therapy ; Chloride Channels/Chloride Channels/Chloride Channels/*metabolism ; Mechanistic Target of Rapamycin Complex 1/Mechanistic Target of Rapamycin Complex 1/Mechanistic Target of Rapamycin Complex 1/*metabolism

• Source: Aging cell [Aging Cell] 2021 Jul; Vol. 20 (7), pp. e13407. Date of Electronic Publication: 2021 Jun 12.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Cap-independent translation: A shared mechanism for lifespan extension by rapamycin, acarbose, and 17α-estradiol.

• Authors : Shen Z; Department of Molecular, Cellular, and Developmental Biology, University of Michigan College of Literature, Science, and the Arts, Ann Arbor, Michigan, USA.; Hinson A

Subjects: Protein Biosynthesis*; Acarbose/Acarbose/Acarbose/*pharmacology ; Estradiol/Estradiol/Estradiol/*pharmacology

• Source: Aging cell [Aging Cell] 2021 May; Vol. 20 (5), pp. e13345. Date of Electronic Publication: 2021 Mar 20.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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TORC1 signaling regulates cytoplasmic pH through Sir2 in yeast.

• Authors : Devare MN; Department of Microbiology and Molecular Biology, College of Bioscience and Biotechnology, Chungnam National University, Daejeon, Korea.; Kim YH

Subjects: Mechanistic Target of Rapamycin Complex 1/Mechanistic Target of Rapamycin Complex 1/Mechanistic Target of Rapamycin Complex 1/*metabolism ; Saccharomyces cerevisiae/Saccharomyces cerevisiae/Saccharomyces cerevisiae/*metabolism ; Saccharomyces cerevisiae Proteins/Saccharomyces cerevisiae Proteins/Saccharomyces cerevisiae Proteins/*metabolism

• Source: Aging cell [Aging Cell] 2020 Jun; Vol. 19 (6), pp. e13151. Date of Electronic Publication: 2020 May 25.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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