نتائج البحث

Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

• Authors : O’Neill, Brian [Pfizer Worldwide Research and Development, Groton, CT (United States). Neuroscience Worldwide Medicinal Chemistry]

• Source: Journal of Medicinal Chemistry; 58; 7

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Decoupling of the PI3K pathway via mutation necessitates combinatorial treatment in HER2+ breast cancer

• Authors : Wong, Kwong [Univ. of Texas, Houston, TX (United States). MD Anderson Cancer Center.]

• Source: PLoS ONE; 10; 7

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Crystal structure of the FLT3 kinase domain bound to the inhibitor quizartinib (AC220)

• Authors : Boggon, Titus [Yale University School of Medicine, New Haven, CT (United States)]

• Source: PLoS ONE; 10; 4

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Local structure of ion pair interaction in lapatinib amorphous dispersions characterized by synchrotron x-ray diffraction and pair distribution function analysis

• Authors : Byrn, Stephen [Purdue Univ., West Lafayette, IN (United States)]

• Source: Scientific Reports; 7

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In Vitro Metabolism and Stability of the Actinide Chelating Agent 3,4,3-LI(1,2-HOPO)

• Authors : Abergel, Rebecca [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Chemical Sciences Division]

• Source: Journal of Pharmaceutical Sciences; 104; 5

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Analysis of Cytochrome P450 CYP119 Ligand-dependent Conformational Dynamics by Two-dimensional NMR and X-ray Crystallography

• Authors : de Montellano, Paul [Univ. of California, San Francisco, CA (United States)]

• Source: Journal of Biological Chemistry; 290; 16

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Characterization of Selective Exosite-Binding Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation in Vitro

• Authors : Minond, Dmitriy [Scripps Research Inst., Jupiter, FL (United States). Lead Identification Division; Torrey Pines Inst. for Molecular Studies, Port St. Lucie, FL (United States). Dept. of Chemistry and Biology]

• Source: Journal of Medicinal Chemistry; 57; 22

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Macro-ions collapse leading to hybrid bio-nanomaterials.

• Authors : Achyuthan, Komandoor

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A Method of Improving non-Cu Jc via a Low-Cost Cu5Sn4 PIT Nb3Sn Conductor for HEP Applications

• Authors : Motowidlo, Leszek

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Innovations in Flow Cytometry Facilitating the Drug Discovery Process

• Authors : Casstevens, Martin

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