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Hydroxychloroquine-Induced Phospholipidosis - A Forgotten Complication of a Common Drug.

• Authors : Kothapalli N; Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India.; Padiyar S

• Source: Indian journal of nephrology [Indian J Nephrol] 2024 Mar-Apr; Vol. 34 (2), pp. 175-177. Date of Electronic Publication: 2023 Aug 04.Publisher: Medknow Country of Publication: India NLM ID: 8914356 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0971-4065 (Print)

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Hydroxychloroquine-Induced Renal Phospholipidosis: Case Report and Review of Differential Diagnoses.

• Authors : Menke AF; Division of General Internal Medicine, Nephrology and Rheumatology, Department of Medicine D, University Hospital of Münster, Münster, Germany.; Heitplatz B

• Source: Case reports in nephrology and dialysis [Case Rep Nephrol Dial] 2024 Feb 16; Vol. 14 (1), pp. 20-29. Date of Electronic Publication: 2024 Feb 16 (Print Publication: 2024).Publisher: Karger AG Country of Publication: Switzerland NLM ID: 101636294 Publication Model: eCollection Cited Medium: Print ISSN: 2296-9705

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Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2.

• Authors : Tummino TA; Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, CA, USA.; Graduate Program in Pharmaceutical Sciences and Pharmacogenomics, UCSF, San Francisco, CA, USA.

Subjects: Drug Repositioning* ; COVID-19 Drug Treatment*; Antiviral Agents/Antiviral Agents/Antiviral Agents/*pharmacology

• Source: Science (New York, N.Y.) [Science] 2021 Jul 30; Vol. 373 (6554), pp. 541-547. Date of Electronic Publication: 2021 Jun 22.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Different Sensitivity of Macrophages to Phospholipidosis Induction by Amphiphilic Cationic Drugs.

• Authors : Öhlinger K; Center for Medical Research, Medical University of Graz, Stiftingtalstr. 24, 8010 Graz, Austria.; Absenger-Novak M

Subjects: Amiodarone/Amiodarone/Amiodarone/*adverse effects ; Cations/Cations/Cations/*adverse effects ; Chloroquine/Chloroquine/Chloroquine/*adverse effects

• Source: International journal of molecular sciences [Int J Mol Sci] 2020 Nov 09; Vol. 21 (21). Date of Electronic Publication: 2020 Nov 09.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Investigating the role of endogenous opioid system in chloroquine-induced phospholipidosis in rat liver by morphological, biochemical and molecular modelling studies.

• Authors : Malek MR; Department of Biochemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran.; Ahmadian S

Subjects: Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/*metabolism ; Fatty Liver/Fatty Liver/Fatty Liver/*metabolism ; Liver/Liver/Liver/*metabolism

• Source: Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2020 Sep; Vol. 47 (9), pp. 1575-1583. Date of Electronic Publication: 2020 May 25.Publisher: Wiley-Blackwell Country of Publication: Australia NLM ID: 0425076 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Zebra-like bodies in COVID-19: is phospholipidosis evidence of hydroxychloroquine induced acute kidney injury?

• Authors : Obeidat M; Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.; Isaacson AL

Subjects: COVID-19 Drug Treatment*; Acute Kidney Injury/Acute Kidney Injury/Acute Kidney Injury/*chemically induced ; Antiviral Agents/Antiviral Agents/Antiviral Agents/*adverse effects

• Source: Ultrastructural pathology [Ultrastruct Pathol] 2020 Nov 20; Vol. 44 (4-6), pp. 519-523. Date of Electronic Publication: 2020 Dec 04.Publisher: Informa Healthcare Country of Publication: England NLM ID: 8002867 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Synthesis of di-docosahexaenoyl (C22:6)-bis(monoacylglycerol) phosphate in unlabelled and C-13 labelled forms for use as a biomarker of drug induced phospholipidosis.

• Authors : Hickey MJ; Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK.; Lindqvist J

Subjects: Carbon Isotopes/Carbon Isotopes/Carbon Isotopes/*chemistry ; Lysosomal Storage Diseases/Lysosomal Storage Diseases/Lysosomal Storage Diseases/*chemically induced ; Lysosomal Storage Diseases/Lysosomal Storage Diseases/Lysosomal Storage Diseases/*metabolism

• Source: Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2019 Sep; Vol. 62 (11), pp. 695-706. Date of Electronic Publication: 2019 May 07.Publisher: Wiley Country of Publication: England NLM ID: 7610510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1344

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Comparison of Oral, Intranasal and Aerosol Administration of Amiodarone in Rats as a Model of Pulmonary Phospholipidosis.

• Authors : Patel A; Sackler Institute of Pulmonary Pharmacology, Faculty of Life Sciences & Medicine, Franklin-Wilkins Building, King's College London, 150 Stamford Street, London SE1 9NH, UK.; Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, King's College London, 150 Stamford Street, London SE1 9NH, UK.

• Source: Pharmaceutics [Pharmaceutics] 2019 Jul 17; Vol. 11 (7). Date of Electronic Publication: 2019 Jul 17.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print)

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Why are most phospholipidosis inducers also hERG blockers?

• Authors : Slavov S; Division of Systems Biology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA.; Stoyanova-Slavova I

Subjects: Quantitative Structure-Activity Relationship*; ERG1 Potassium Channel/ERG1 Potassium Channel/ERG1 Potassium Channel/*antagonists & inhibitors ; Lipidoses/Lipidoses/Lipidoses/*chemically induced

• Source: Archives of toxicology [Arch Toxicol] 2017 Dec; Vol. 91 (12), pp. 3885-3895. Date of Electronic Publication: 2017 May 27.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Characteristics of corneal phospholipidosis induced by topical ocular application of chloroquine and amiodarone in rabbits.

• Authors : Yamagiwa Y; Pharmacokinetics and Toxicology Research Laboratories, Senju Pharmaceutical Co., Ltd., 1-5-4 Murotani, Nishi-ku, Kobe, Hyogo 651-2241, Japan.; Haranosono Y

• Source: Journal of toxicologic pathology [J Toxicol Pathol] 2017 Apr; Vol. 30 (2), pp. 135-143. Date of Electronic Publication: 2016 Nov 27.Publisher: Japanese Society of Toxicologic Pathology Country of Publication: Japan NLM ID: 9306408 Publication Model: Print-Electronic Cited Medium:

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