نتائج البحث

Reversible male contraception by targeted inhibition of serine/threonine kinase 33.

• Authors : Ku AF; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA.; Sharma KL

Subjects: Contraceptive Agents, Male*/Contraceptive Agents, Male*/Contraceptive Agents, Male*/chemistry ; Contraceptive Agents, Male*/Contraceptive Agents, Male*/Contraceptive Agents, Male*/pharmacology ; Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/pharmacology

• Source: Science (New York, N.Y.) [Science] 2024 May 24; Vol. 384 (6698), pp. 885-890. Date of Electronic Publication: 2024 May 23.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Design of stimulus-responsive two-state hinge proteins.

• Authors : Praetorius F; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.

Subjects: Protein Engineering*/Protein Engineering*/Protein Engineering*/methods; Crystallography, X-Ray ; Ligands

• Source: Science (New York, N.Y.) [Science] 2023 Aug 18; Vol. 381 (6659), pp. 754-760. Date of Electronic Publication: 2023 Aug 17.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors.

• Authors : Jimmidi R; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, 77030, USA.; Chamakuri S

• Source: Communications chemistry [Commun Chem] 2023 Aug 04; Vol. 6 (1), pp. 164. Date of Electronic Publication: 2023 Aug 04.Publisher: Springer Nature Country of Publication: England NLM ID: 101725670 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3669

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Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M β-lactamase.

• Authors : Judge A; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.; Hu L

Subjects: beta-Lactamases*/beta-Lactamases*/beta-Lactamases*/metabolism ; Ceftazidime*/Ceftazidime*/Ceftazidime*/pharmacology ; Escherichia coli*/Escherichia coli*/Escherichia coli*/metabolism

• Source: Communications biology [Commun Biol] 2023 Jan 12; Vol. 6 (1), pp. 35. Date of Electronic Publication: 2023 Jan 12.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Novel fold of rotavirus glycan-binding domain predicted by AlphaFold2 and determined by X-ray crystallography.

• Authors : Hu L; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA. .; Salmen W

Subjects: Rotavirus*/Rotavirus*/Rotavirus*/chemistry ; Rotavirus*/Rotavirus*/Rotavirus*/metabolism; Capsid Proteins/Capsid Proteins/Capsid Proteins/metabolism

• Source: Communications biology [Commun Biol] 2022 May 05; Vol. 5 (1), pp. 419. Date of Electronic Publication: 2022 May 05.Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN:

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Discovery of small molecules targeting the tandem tudor domain of the epigenetic factor UHRF1 using fragment-based ligand discovery.

• Authors : Chang L; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, 77030, USA.; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, 77030, USA.

Subjects: Drug Discovery* ; Small Molecule Libraries* ; Tudor Domain*

• Source: Scientific reports [Sci Rep] 2021 Jan 13; Vol. 11 (1), pp. 1121. Date of Electronic Publication: 2021 Jan 13.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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De novo design of tunable, pH-driven conformational changes.

• Authors : Boyken SE; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.

Subjects: Protein Conformation* ; Protein Multimerization*; Protein Engineering/Protein Engineering/Protein Engineering/*methods

• Source: Science (New York, N.Y.) [Science] 2019 May 17; Vol. 364 (6441), pp. 658-664.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium:

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Arsinothricin, an arsenic-containing non-proteinogenic amino acid analog of glutamate, is a broad-spectrum antibiotic.

• Authors : Nadar VS; 1Department of Cellular Biology and Pharmacology, Florida International University, Herbert Wertheim College of Medicine, Miami, FL 33199 USA.; Chen J

Subjects: Anti-Bacterial Agents/Anti-Bacterial Agents/Anti-Bacterial Agents/*chemistry ; Anti-Bacterial Agents/Anti-Bacterial Agents/Anti-Bacterial Agents/*pharmacology ; Arsenicals/Arsenicals/Arsenicals/*chemistry

• Source: Communications biology [Commun Biol] 2019 Apr 15; Vol. 2, pp. 131. Date of Electronic Publication: 2019 Apr 15 (Print Publication: 2019).Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: eCollection Cited Medium: Internet ISSN:

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Ab initio structure solution of a proteolytic fragment using ARCIMBOLDO.

• Authors : Abendroth J; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA.; Sankaran B

Subjects: Software*; Bacterial Proteins/Bacterial Proteins/Bacterial Proteins/*chemistry ; GTP Phosphohydrolases/GTP Phosphohydrolases/GTP Phosphohydrolases/*chemistry

• Source: Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2018 Sep 01; Vol. 74 (Pt 9), pp. 530-535. Date of Electronic Publication: Publisher: John Wiley & Sons Inc Country of Publication: United States NLM ID: 101620319 Publication Model: Print-Electronic Cited Medium: Internet

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Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity.

• Authors : Lorenz R; Department of Biochemistry, University of Kassel, Kassel, Hesse, Germany.; Moon EW

Subjects: Models, Molecular*; Cyclic AMP/Cyclic AMP/Cyclic AMP/*metabolism ; Cyclic AMP-Dependent Protein Kinase RIalpha Subunit/Cyclic AMP-Dependent Protein Kinase RIalpha Subunit/Cyclic AMP-Dependent Protein Kinase RIalpha Subunit/*metabolism

• Source: The Biochemical journal [Biochem J] 2017 Jul 06; Vol. 474 (14), pp. 2389-2403. Date of Electronic Publication: 2017 Jul 06.Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Electronic

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