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Academic Journal

Regulation of STAT5 phosphorylation and interaction with SHP1 by lnc-AC004893, a long non-coding RNA overexpressed in myeloproliferative neoplasms.

  • Authors : Yang J; Department of Laboratory Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.; Ruan J

Subjects: STAT5 Transcription Factor*/STAT5 Transcription Factor*/STAT5 Transcription Factor*/metabolism ; STAT5 Transcription Factor*/STAT5 Transcription Factor*/STAT5 Transcription Factor*/genetics ; RNA, Long Noncoding*/RNA, Long Noncoding*/RNA, Long Noncoding*/genetics

  • Source: Hematology (Amsterdam, Netherlands) [Hematology] 2024 Dec; Vol. 29 (1), pp. 2375045. Date of Electronic Publication: 2024 Jul 16.Publisher: Taylor & Francis Country of Publication: England NLM ID: 9708388 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Synthesis and Biological Evaluation of 3-Amino-4,4-Dimethyl Lithocholic Acid Derivatives as Novel, Selective, and Cellularly Active Allosteric SHP1 Activators.

  • Authors : Chen H; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.; Liu Z

Subjects: Signal Transduction* ; Protein Tyrosine Phosphatases*/Protein Tyrosine Phosphatases*/Protein Tyrosine Phosphatases*/metabolism; Protein Tyrosine Phosphatase, Non-Receptor Type 6/Protein Tyrosine Phosphatase, Non-Receptor Type 6/Protein Tyrosine Phosphatase, Non-Receptor Type 6/metabolism

  • Source: Molecules (Basel, Switzerland) [Molecules] 2023 Mar 08; Vol. 28 (6). Date of Electronic Publication: 2023 Mar 08.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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Academic Journal

Epstein-barr virus/ Helicobacter pylori coinfection and gastric cancer: the possible role of viral gene expression and shp1 methylation.

  • Authors : Estaji F; Department of Bacteriology and Virology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.; Nasr Esfahani B

  • Source: Iranian journal of microbiology [Iran J Microbiol] 2022 Dec; Vol. 14 (6), pp. 901-912.Publisher: Tehran University of Medical Sciences Country of Publication: Iran NLM ID: 101518404 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Global and promoter specific hypermethylation of tumor suppressor genes P16, SOCS1, and SHP1 in oral squamous cell carcinoma and oral submucous fibrosis.

  • Authors : Ukey S; All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.; Jain A

Subjects: Carcinoma, Squamous Cell*/Carcinoma, Squamous Cell*/Carcinoma, Squamous Cell*/pathology ; Head and Neck Neoplasms*/Head and Neck Neoplasms*/Head and Neck Neoplasms*/genetics ; Mouth Neoplasms*/Mouth Neoplasms*/Mouth Neoplasms*/pathology

  • Source: Journal of cancer research and therapeutics [J Cancer Res Ther] 2023 Jan 01; Vol. 19 (Suppl 2), pp. S551-S559. Date of Electronic Publication: 2023 Apr 29.Publisher: Medknow Publications Country of Publication: India NLM ID: 101249598 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The phosphatase Shp1 interacts with and dephosphorylates cortactin to inhibit invadopodia function.

  • Authors : Varone A; Institute of Biochemistry and Cell Biology, National Research Council, Via Pietro Castellino 111, 80131, Naples, Italy. .; Amoruso C

Subjects: Cortactin/Cortactin/Cortactin/*metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 6/Protein Tyrosine Phosphatase, Non-Receptor Type 6/Protein Tyrosine Phosphatase, Non-Receptor Type 6/*metabolism ; Pseudopodia/Pseudopodia/Pseudopodia/*metabolism

  • Source: Cell communication and signaling : CCS [Cell Commun Signal] 2021 Jun 04; Vol. 19 (1), pp. 64. Date of Electronic Publication: 2021 Jun 04.Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X

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Academic Journal

Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals.

  • Authors : Jiang M; 1School of Public Health, Qingdao University, Qingdao, China.; Ye J

  • Source: Cell & bioscience [Cell Biosci] 2020 May 14; Vol. 10, pp. 65. Date of Electronic Publication: 2020 May 14 (Print Publication: 2020).Publisher: BioMed Central Country of Publication: England NLM ID: 101561195 Publication Model: eCollection Cited Medium: Print ISSN: 2045-3701

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Academic Journal

Immunosuppressive receptor LILRB1 acts as a potential regulator in hepatocellular carcinoma by integrating with SHP1.

  • Authors : Cheng J; Shaanxi Key Laboratory of Brain Disorders and School of Basic Medical Science, Xi'an Medical University, Xi'an, Shaanxi, China.; Shaanxi Key Laboratory of Brain Disorders and School of Basic Medical Science, Xi'an Medical University, Xi'an, Shaanxi, China.

Subjects: Antigens, CD/Antigens, CD/Antigens, CD/*metabolism ; Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/*pathology ; Leukocyte Immunoglobulin-like Receptor B1/Leukocyte Immunoglobulin-like Receptor B1/Leukocyte Immunoglobulin-like Receptor B1/*metabolism

  • Source: Cancer biomarkers : section A of Disease markers [Cancer Biomark] 2020; Vol. 28 (3), pp. 309-319.Publisher: IOS Press Country of Publication: Netherlands NLM ID: 101256509 Publication Model: Print Cited Medium: Internet ISSN: 1875-8592

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Academic Journal

A signalling cascade involving receptor-activated phospholipase A 2 , glycerophosphoinositol 4-phosphate, Shp1 and Src in the activation of cell motility.

  • Authors : Varone A; Institute of Protein Biochemistry, National Research Council, Via Pietro Castellino 111, 80131, Naples, Italy. .; Mariggiò S

Subjects: Cell Movement* ; Signal Transduction*; ErbB Receptors/ErbB Receptors/ErbB Receptors/*metabolism

  • Source: Cell communication and signaling : CCS [Cell Commun Signal] 2019 Mar 01; Vol. 17 (1), pp. 20. Date of Electronic Publication: 2019 Mar 01.Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X

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Academic Journal

SHP1 and SHP2 inhibition enhances the pro-differentiative effect of phorbol esters: an alternative approach against acute myeloid leukemia.

  • Authors : Pérez-Fernández A; Department of Biochemistry and Molecular Biology, University of Salamanca, Edificio Departamental, Lab 122, Plaza Doctores de la Reina, S/N, P.O. 37007, Salamanca, Spain.; IBSAL, Institute for Biomedical Research of Salamanca, Virgen de la Vega Hospital, 10th floor, Paseo de San Vicente, 58-182, P.O. 37007, Salamanca, Spain.

Subjects: Cell Differentiation/Cell Differentiation/Cell Differentiation/*drug effects ; Leukemia, Myeloid, Acute/Leukemia, Myeloid, Acute/Leukemia, Myeloid, Acute/*pathology ; Phorbol Esters/Phorbol Esters/Phorbol Esters/*pharmacology

  • Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2019 Feb 14; Vol. 38 (1), pp. 80. Date of Electronic Publication: 2019 Feb 14.Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966

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Academic Journal

Vanadium pentoxide increased PTEN and decreased SHP1 expression in NK-92MI cells, affecting PI3K-AKT-mTOR and Ras-MAPK pathways.

  • Authors : Gallardo-Vera F; a Laboratorio de Inmunobiología, Departamento de Biología Celular y Tisular, Facultad de Medicina, UNAM , Mexico City , México.; Tapia-Rodriguez M

Subjects: Killer Cells, Natural/Killer Cells, Natural/Killer Cells, Natural/*physiology ; PTEN Phosphohydrolase/PTEN Phosphohydrolase/PTEN Phosphohydrolase/*metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 6/Protein Tyrosine Phosphatase, Non-Receptor Type 6/Protein Tyrosine Phosphatase, Non-Receptor Type 6/*metabolism

  • Source: Journal of immunotoxicology [J Immunotoxicol] 2018 Dec; Vol. 15 (1), pp. 1-11.Publisher: Informa Healthcare Country of Publication: England NLM ID: 101201960 Publication Model: Print Cited Medium: Internet ISSN: 1547-6901

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