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Trabectedin Induces Synthetic Lethality via the p53-Dependent Apoptotic Pathway in Ovarian Cancer Cells Without BRCA Mutations When Used in Combination with Niraparib.

• Authors : Kang B; Department of Chemistry, College of Natural Science, Kyungpook National University, Daegu 41944, Republic of Korea.; Lee SJ

Subjects: Apoptosis*/Apoptosis*/Apoptosis*/drug effects ; Tumor Suppressor Protein p53*/Tumor Suppressor Protein p53*/Tumor Suppressor Protein p53*/metabolism ; Tumor Suppressor Protein p53*/Tumor Suppressor Protein p53*/Tumor Suppressor Protein p53*/genetics

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 Mar 24; Vol. 26 (7). Date of Electronic Publication: 2025 Mar 24.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Objective and subjective suicidal intent are differentially associated with attempt lethality based on age of onset of suicidal behavior.

• Authors : Szücs A; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. .; Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. .

Subjects: Suicide, Attempted*/Suicide, Attempted*/Suicide, Attempted*/psychology ; Suicidal Ideation* ; Age of Onset*

• Source: Scientific reports [Sci Rep] 2025 Feb 15; Vol. 15 (1), pp. 5621. Date of Electronic Publication: 2025 Feb 15.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Synthetic lethality in cancer: a protocol for scoping review of gene interactions from synthetic lethal screens and functional studies.

• Authors : Chauhan R; Department of Medical Genetics, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.; Damerla RR

Subjects: Neoplasms*/Neoplasms*/Neoplasms*/genetics ; Neoplasms*/Neoplasms*/Neoplasms*/drug therapy ; Synthetic Lethal Mutations*

• Source: Systematic reviews [Syst Rev] 2025 Apr 08; Vol. 14 (1), pp. 81. Date of Electronic Publication: 2025 Apr 08.Publisher: BioMed Central Country of Publication: England NLM ID: 101580575 Publication Model: Electronic Cited Medium: Internet ISSN: 2046-4053

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Prion-Dependent Lethality of sup35 Missense Mutations Is Caused by Low GTPase Activity of the Mutant eRF3 Protein.

• Authors : Trubitsina NP; Department of Genetics and Biotechnology, St. Petersburg State University, 199034 St. Petersburg, Russia.; Zemlyanko OM

Subjects: Peptide Termination Factors*/Peptide Termination Factors*/Peptide Termination Factors*/genetics ; Peptide Termination Factors*/Peptide Termination Factors*/Peptide Termination Factors*/metabolism ; Peptide Termination Factors*/Peptide Termination Factors*/Peptide Termination Factors*/chemistry

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 Apr 06; Vol. 26 (7). Date of Electronic Publication: 2025 Apr 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Synthetic Lethality of SHP2 and XIAP Suppresses Proliferation and Metastasis in KRAS-mutant Nonsmall Cell Lung Cancer.

• Authors : Fu NJ; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China.; Sheng YW

Subjects: Protein Tyrosine Phosphatase, Non-Receptor Type 11*/Protein Tyrosine Phosphatase, Non-Receptor Type 11*/Protein Tyrosine Phosphatase, Non-Receptor Type 11*/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 11*/Protein Tyrosine Phosphatase, Non-Receptor Type 11*/Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism ; Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/genetics

• Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Apr; Vol. 12 (15), pp. e2411642. Date of Electronic Publication: 2025 Feb 24.Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844

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Testing the psychometric properties of the risk-rescue rating scale: a lethality measure for suicide attempts.

• Authors : Stangeland T; Division of Mental Health Services, Akershus University Hospital, Lørenskog, Norway. .; Campus Ahus, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. .

• Source: International journal of mental health systems [Int J Ment Health Syst] 2025 Jan 30; Vol. 19 (1), pp. 5. Date of Electronic Publication: 2025 Jan 30.Publisher: BioMed Central Country of Publication: England NLM ID: 101294224 Publication Model: Electronic Cited Medium: Print ISSN: 1752-4458

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Personality Dimension, Suicidal Intent, and Lethality: A Cross-sectional Study of Suicide Attempters with or Without Personality Disorders.

• Authors : Sahoo A; Dept. of Psychiatry, Mental Health Institute, S.C.B. Medical College and Hospital, Cuttack, Odisha, India.; Swain SP

• Source: Indian journal of psychological medicine [Indian J Psychol Med] 2024 Nov 15, pp. 02537176241287161. Date of Electronic Publication: 2024 Nov 15.Publisher: SAGE Publications Country of Publication: United States NLM ID: 7910727 Publication Model: Print-Electronic Cited Medium: Print ISSN:

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Metabonomics and Transcriptomics Analyses Reveal the Underlying HPA-Axis-Related Mechanisms of Lethality in Larimichthys polyactis Exposed to Underwater Noise Pollution.

• Authors : Jiang Q; Zhejiang Key Laboratory of Coastal Biological Germplasm Resources Conservation and Utilization, Institute of Hydrobiology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310000, China.; Zhang Y

Subjects: Metabolomics* ; Gene Expression Profiling* ; Noise*

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Nov 24; Vol. 25 (23). Date of Electronic Publication: 2024 Nov 24.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Second generation lethality in RNAseH2a knockout zebrafish.

• Authors : Thomas RC; Bateson Centre, School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK.; Healthy Lifespan Institute, Sheffield Institute for Neuroscience, University of Sheffield, Sheffield S10 2TN, UK.

Subjects: Ribonuclease H*/Ribonuclease H*/Ribonuclease H*/genetics ; Ribonuclease H*/Ribonuclease H*/Ribonuclease H*/metabolism ; Zebrafish*/Zebrafish*/Zebrafish*/genetics

• Source: Nucleic acids research [Nucleic Acids Res] 2024 Oct 14; Vol. 52 (18), pp. 11014-11028.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Disrupting YAP1-mediated glutamine metabolism induces synthetic lethality alongside ODC1 inhibition in osteosarcoma.

• Authors : Wang H; Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China.; Shanghai Bone Tumor Institution, Shanghai, China.

Subjects: Osteosarcoma*/Osteosarcoma*/Osteosarcoma*/metabolism ; Osteosarcoma*/Osteosarcoma*/Osteosarcoma*/pathology ; Osteosarcoma*/Osteosarcoma*/Osteosarcoma*/genetics

• Source: Cellular oncology (Dordrecht, Netherlands) [Cell Oncol (Dordr)] 2024 Oct; Vol. 47 (5), pp. 1845-1861. Date of Electronic Publication: 2024 Aug 08.Publisher: Springer Country of Publication: Netherlands NLM ID: 101552938 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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