نتائج البحث

Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene[3,2- d ]pyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluation.

• Authors : Zhuo Z; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.; Wang Z

Subjects: Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/pharmacology ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemistry ; Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/Reverse Transcriptase Inhibitors*/chemical synthesis

• Source: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 20; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

تفاصيل العنوان

Croconaine-based NIR-II fluorescence imaging-guided tumor photothermal therapy induces long-term antitumor immune memory.

• Authors : Dong Y; Department of Urology, Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatric, Shenzhen People's Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong, 518020, P. R. China.; Department of Urology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, 510500, P. R. China.

Subjects: Photothermal Therapy*/Photothermal Therapy*/Photothermal Therapy*/methods ; Optical Imaging*/Optical Imaging*/Optical Imaging*/methods ; Mice, Inbred BALB C*

• Source: Journal of nanobiotechnology [J Nanobiotechnology] 2024 Aug 13; Vol. 22 (1), pp. 481. Date of Electronic Publication: 2024 Aug 13.Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155

تفاصيل العنوان

Nanobody-Engineered Biohybrid Bacteria Targeting Gastrointestinal Cancers Induce Robust STING-Mediated Anti-Tumor Immunity.

• Authors : Xu X; Department of Geriatrics and Shenzhen Clinical Research Centre for Geriatrics, Department of Urology, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University), Shenzhen, Guangdong, 518020, China.; Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, 510632, China.

Subjects: Single-Domain Antibodies*/Single-Domain Antibodies*/Single-Domain Antibodies*/immunology ; Gastrointestinal Neoplasms*/Gastrointestinal Neoplasms*/Gastrointestinal Neoplasms*/immunology ; Gastrointestinal Neoplasms*/Gastrointestinal Neoplasms*/Gastrointestinal Neoplasms*/therapy

• Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Aug; Vol. 11 (31), pp. e2401905. Date of Electronic Publication: 2024 Jun 18.Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844

تفاصيل العنوان

The Increased Dissolution and Oral Absorption of Itraconazole by Nanocrystals with an Endogenous Small-Molecule Surfactant as a Stabilizer.

• Authors : Chang S; College of Pharmacy, Jilin Medical University, Jilin 132013, China.; Yang Q

Subjects: Itraconazole*/Itraconazole*/Itraconazole*/chemistry ; Itraconazole*/Itraconazole*/Itraconazole*/pharmacokinetics ; Itraconazole*/Itraconazole*/Itraconazole*/administration & dosage

• Source: Molecules (Basel, Switzerland) [Molecules] 2024 Apr 13; Vol. 29 (8). Date of Electronic Publication: 2024 Apr 13.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

تفاصيل العنوان

Dynamic changes of Bacterial Microbiomes in Oropharynx during Infection and Recovery of COVID-19 Omicron Variant.

• Authors : Cui G; Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Sun Y

Subjects: COVID-19* ; Cross Infection* ; Microbiota*/Microbiota*/Microbiota*/geneticsSARS-CoV-2 variants

• Source: PLoS pathogens [PLoS Pathog] 2024 Apr 03; Vol. 20 (4), pp. e1012075. Date of Electronic Publication: 2024 Apr 03 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet

تفاصيل العنوان

Immune Dysregulation in SARS-CoV-2 patients coinfected with Mycobacterium tuberculosis (Mtb) or HIV in China.

• Authors : Li L; Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, #1 Jianshe East Road, 450052, Zhengzhou, China.; State Key Laboratory of Antiviral Drugs, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China.

Subjects: Mycobacterium tuberculosis* ; Coinfection*/Coinfection*/Coinfection*/epidemiology ; HIV Infections*/HIV Infections*/HIV Infections*/complications

• Source: BMC public health [BMC Public Health] 2024 Feb 22; Vol. 24 (1), pp. 556. Date of Electronic Publication: 2024 Feb 22.Publisher: BioMed Central Country of Publication: England NLM ID: 100968562 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2458

تفاصيل العنوان

Chemoproteomics-based profiling reveals potential antimalarial mechanism of Celastrol by disrupting spermidine and protein synthesis.

• Authors : Gao P; Department of rehabilitation medicine, Shunde Hospital, Southern Medical University, Foshan, 528300, China.; Wang J

Subjects: Antimalarials*/Antimalarials*/Antimalarials*/pharmacology ; Antimalarials*/Antimalarials*/Antimalarials*/chemistry ; Antimalarials*/Antimalarials*/Antimalarials*/therapeutic use

• Source: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Feb 20; Vol. 22 (1), pp. 139. Date of Electronic Publication: 2024 Feb 20.Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X

تفاصيل العنوان

Photoaffinity probe-based antimalarial target identification of artemisinin in the intraerythrocytic developmental cycle of Plasmodium falciparum .

• Authors : Gao P; State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medical China Academy of Chinese Medical Sciences Beijing China.; Department of Pulmonary and Critical Care Medicine, Shenzhen Institute of Respiratory Diseases, and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital

• Source: IMeta [Imeta] 2024 Feb 19; Vol. 3 (2), pp. e176. Date of Electronic Publication: 2024 Feb 19 (Print Publication: 2024).Publisher: John Wiley & Sons Australia, Ltd on behalf of iMeta Science Country of Publication: Australia NLM ID: 9918350383706676 Publication Model:

تفاصيل العنوان

Xiao Cheng Qi Decoction, an Ancient Chinese Herbal Mixture, Relieves Loperamide-Induced Slow-Transit Constipation in Mice: An Action Mediated by Gut Microbiota.

• Authors : Tuohongerbieke A; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Shenzhen 518057, China.; Wang H

• Source: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2024 Jan 24; Vol. 17 (2). Date of Electronic Publication: 2024 Jan 24.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print)

تفاصيل العنوان

A novel N -heterocycles substituted oseltamivir derivatives as potent inhibitors of influenza virus neuraminidase: discovery, synthesis and biological evaluation.

• Authors : Zhang J; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China.; Liu C

Subjects: Influenza A Virus, H5N1 Subtype*/Influenza A Virus, H5N1 Subtype*/Influenza A Virus, H5N1 Subtype*/metabolism ; Influenza A Virus, H1N1 Subtype*; Oseltamivir/Oseltamivir/Oseltamivir/pharmacology

• Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2277135. Date of Electronic Publication: 2023 Nov 13.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

تفاصيل العنوان