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Academic Journal

Hallmarks of Testicular Aging: The Challenge of Anti-Inflammatory and Antioxidant Therapies Using Natural and/or Pharmacological Compounds to Improve the Physiopathological Status of the Aged Male Gonad.

  • Authors : Matzkin ME; Instituto de Biología y Medicina Experimental, CONICET, Ciudad de Buenos Aires C1428ADN, Argentina.; Departamento de Bioquímica Humana, Cátedra I, Facultad de Medicina, Universidad de Buenos Aires, Ciudad de Buenos Aires C1121ABG, Argentina.

Subjects: Aging/Aging/Aging/*pathology ; Anti-Inflammatory Agents/Anti-Inflammatory Agents/Anti-Inflammatory Agents/*pharmacology ; Antioxidants/Antioxidants/Antioxidants/*pharmacology

  • Source: Cells [Cells] 2021 Nov 10; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 10.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409

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Academic Journal

Three-dimensional morphological analysis of spermatogenesis in aged mouse testes.

  • Authors : Nakano T; Department of Integrative Cancer Therapy and Urology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.; Nakata H

Subjects: Aging* ; Spermatogenesis*; Seminiferous Tubules/Seminiferous Tubules/Seminiferous Tubules/*ultrastructure

  • Source: Scientific reports [Sci Rep] 2021 Nov 26; Vol. 11 (1), pp. 23007. Date of Electronic Publication: 2021 Nov 26.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Impaired macrophages and failure of steroidogenesis and spermatogenesis in rat testes with cytokines deficiency induced by diacerein.

  • Authors : de Oliveira SA; Department of Morphology and Genetics, Federal University of São Paulo, São Paulo, Brazil.; Cerri PS

Subjects: Anthraquinones/Anthraquinones/Anthraquinones/*pharmacology ; Anti-Inflammatory Agents/Anti-Inflammatory Agents/Anti-Inflammatory Agents/*pharmacology ; Cytokines/Cytokines/Cytokines/*antagonists & inhibitors

  • Source: Histochemistry and cell biology [Histochem Cell Biol] 2021 Dec; Vol. 156 (6), pp. 561-581. Date of Electronic Publication: 2021 Sep 13.Publisher: Springer Country of Publication: Germany NLM ID: 9506663 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-119X

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Academic Journal

Deletion of DDB1- and CUL4- associated factor-17 (Dcaf17) gene causes spermatogenesis defects and male infertility in mice.

  • Authors : Ali A; Comparative Medicine Department, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211, Saudi Arabia.; Mistry BV

Subjects: Aging*/Aging*/Aging*/genetics ; Aging*/Aging*/Aging*/metabolism ; Aging*/Aging*/Aging*/pathology

  • Source: Scientific reports [Sci Rep] 2018 Jun 15; Vol. 8 (1), pp. 9202. Date of Electronic Publication: 2018 Jun 15.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Short-term starvation stress at young adult stages enhances meiotic activity of germ cells to maintain spermatogenesis in aged male Caenorhabditis elegans.

  • Authors : Chou WY; Laboratory of Molecular Pathology, Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.; Lin YC

Subjects: Aging/Aging/Aging/*genetics ; Caenorhabditis elegans/Caenorhabditis elegans/Caenorhabditis elegans/*genetics ; Caenorhabditis elegans/Caenorhabditis elegans/Caenorhabditis elegans/*growth & development

  • Source: Aging cell [Aging Cell] 2019 Jun; Vol. 18 (3), pp. e12930. Date of Electronic Publication: 2019 Feb 28.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Oxidative stress burden inhibits spermatogenesis in adult male rats: testosterone protective effect.

  • Authors : Makary S; a Department of Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.; Abdo M

Subjects: Aging/Aging/Aging/*metabolism ; Oxidative Stress/Oxidative Stress/Oxidative Stress/*drug effects ; Protective Agents/Protective Agents/Protective Agents/*pharmacology

  • Source: Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2018 Apr; Vol. 96 (4), pp. 372-381. Date of Electronic Publication: 2017 Nov 23.Publisher: Canadian Science Publishing Country of Publication: Canada NLM ID: 0372712 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Integrin restriction by miR-34 protects germline progenitors from cell death during aging.

  • Authors : Perry N; Department of Human Biology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.; Braun R

Subjects: MicroRNAs*/MicroRNAs*/MicroRNAs*/metabolism ; MicroRNAs*/MicroRNAs*/MicroRNAs*/genetics ; Germ Cells*/Germ Cells*/Germ Cells*/metabolism

  • Source: Aging cell [Aging Cell] 2024 Jun; Vol. 23 (6), pp. e14131. Date of Electronic Publication: 2024 Mar 07.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Protective Role of Spirulina platensis Against Bifenthrin-Induced Reprotoxicity in Adult Male Mice by Reversing Expression of Altered Histological, Biochemical, and Molecular Markers Including MicroRNAs.

  • Authors : Barkallah M; Unité de Biotechnologie des Algues, Biological Engineering Department, National Engineering School of Sfax, University of Sfax, Sfax 3038, Tunisia.; Slima AB

Subjects: Aging/Aging/Aging/*pathology ; Biomarkers/Biomarkers/Biomarkers/*metabolism ; Gene Expression Regulation/Gene Expression Regulation/Gene Expression Regulation/*drug effects Arthrospira platensis

  • Source: Biomolecules [Biomolecules] 2020 May 12; Vol. 10 (5). Date of Electronic Publication: 2020 May 12.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X

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Academic Journal

Vitamin D3 regulates apoptosis and proliferation in the testis of D-galactose-induced aged rat model.

Subjects: Aging/Aging/Aging/*drug effects ; Aging/Aging/Aging/*metabolism ; Apoptosis/Apoptosis/Apoptosis/*drug effects

  • Source: Scientific reports [Sci Rep] 2019 Oct 01; Vol. 9 (1), pp. 14103. Date of Electronic Publication: 2019 Oct 01.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Cordycepin, an Active Constituent of Nutrient Powerhouse and Potential Medicinal Mushroom Cordyceps militaris Linn., Ameliorates Age-Related Testicular Dysfunction in Rats.

  • Authors : Kopalli SR; Department of Bioscience and Biotechnology, Sejong University, Gwangjin-gu, Seoul 05006, Korea. .; Cha KM

Subjects: Aging*; Cordyceps/Cordyceps/Cordyceps/*chemistry ; Deoxyadenosines/Deoxyadenosines/Deoxyadenosines/*pharmacology

  • Source: Nutrients [Nutrients] 2019 Apr 23; Vol. 11 (4). Date of Electronic Publication: 2019 Apr 23.Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Testicular length as an indicator of the onset of sperm production in alpacas under Swedish conditions.

  • Authors : Abraham MC; Division of Reproduction, Department of Clinical Sciences, Swedish University of Agricultural Sciences, Box 7054, 75007, Uppsala, Sweden. .; Puhakka J

Subjects: Aging* ; Body Composition* ; Spermatogenesis*

  • Source: Acta veterinaria Scandinavica [Acta Vet Scand] 2016 Feb 02; Vol. 58, pp. 10. Date of Electronic Publication: 2016 Feb 02.Publisher: BioMed Central Country of Publication: England NLM ID: 0370400 Publication Model: Electronic Cited Medium: Internet ISSN: 1751-0147

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Academic Journal

Cytochrome P450 3A1 mediates 2,2',4,4'-tetrabromodiphenyl ether-induced reduction of spermatogenesis in adult rats.

  • Authors : Zhang Z; State Key Lab of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, Jiangsu, P.R.China.; Zhang X

Subjects: Aging/Aging/Aging/*metabolism ; Cytochrome P-450 CYP3A/Cytochrome P-450 CYP3A/Cytochrome P-450 CYP3A/*metabolism ; Halogenated Diphenyl Ethers/Halogenated Diphenyl Ethers/Halogenated Diphenyl Ethers/*pharmacology

  • Source: PloS one [PLoS One] 2013 Jun 07; Vol. 8 (6), pp. e66301. Date of Electronic Publication: 2013 Jun 07 (Print Publication: 2013).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Electronic-Print Cited Medium: Internet

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Academic Journal

Diet Supplemented with Antioxidant and Anti-Inflammatory Probiotics Improves Sperm Quality after Only One Spermatogenic Cycle in Zebrafish Model.

  • Authors : Valcarce DG; IEO, Spanish Institute of Oceanography, Planta de Cultivos El Bocal, Barrio Corbanera, 39012 Monte, Santander, Spain. .; Riesco MF

Subjects: Dietary Supplements* ; Probiotics*; Anti-Inflammatory Agents/Anti-Inflammatory Agents/Anti-Inflammatory Agents/*pharmacology

  • Source: Nutrients [Nutrients] 2019 Apr 13; Vol. 11 (4). Date of Electronic Publication: 2019 Apr 13.Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Repeated inhalation of crack-cocaine affects spermatogenesis in young and adult mice.

  • Authors : Pires A; Reproductive Toxicology Unit, Experimental Air Pollution Laboratory, São Paulo University Medical School, São Paulo, SP, Brazil. ; Pieri P

Subjects: Aging/Aging/Aging/*physiology ; Crack Cocaine/Crack Cocaine/Crack Cocaine/*toxicity ; Smoke/Smoke/Smoke/*adverse effects

  • Source: Inhalation toxicology [Inhal Toxicol] 2012 Jun; Vol. 24 (7), pp. 439-46.Publisher: Informa Healthcare Country of Publication: England NLM ID: 8910739 Publication Model: Print Cited Medium: Internet ISSN: 1091-7691

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Academic Journal

Aging deteriorates quality of sperm produced by male mice with partial Yq deletion.

  • Authors : Kotarska K; a Department of Experimental Neuroendocrinology , Institute of Pharmacology, Polish Academy of Sciences , Krakow , Poland.; b Department of Genetics and Evolution , Institute of Zoology and Biomedical Research, Jagiellonian University , Krakow , Poland.

Subjects: Chromosome Deletion*; Aging/Aging/Aging/*physiology ; Spermatozoa/Spermatozoa/Spermatozoa/*physiology

  • Source: Systems biology in reproductive medicine [Syst Biol Reprod Med] 2017 Dec; Vol. 63 (6), pp. 360-363. Date of Electronic Publication: 2017 Nov 03.Publisher: Informa Healthcare Country of Publication: England NLM ID: 101464963 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Transcriptional coactivator with PDZ-binding motif is required to sustain testicular function on aging.

  • Authors : Jeong MG; College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Korea.; Song H

Subjects: Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/*genetics ; Aging/Aging/Aging/*genetics ; Cyclin-Dependent Kinase Inhibitor p21/Cyclin-Dependent Kinase Inhibitor p21/Cyclin-Dependent Kinase Inhibitor p21/*genetics

  • Source: Aging cell [Aging Cell] 2017 Oct; Vol. 16 (5), pp. 1035-1042. Date of Electronic Publication: 2017 Jun 14.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Developmental expression of the protein kinase C substrate/binding protein (clone 72/SSeCKS) in rat testis identification as a scaffolding protein containing an A-kinase-anchoring domain which is expressed during late-stage spermatogenesis.

Subjects: Cell Cycle Proteins* ; Gene Expression Regulation, Developmental*; Aging/Aging/Aging/*metabolism

  • Source: European journal of biochemistry [Eur J Biochem] 1999 Aug; Vol. 263 (3), pp. 797-805.Publisher: Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 0107600 Publication Model:

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Academic Journal

Mixed testicular atrophy related to atherosclerosis: first lessons from the ApoE(-/-)/ LDL receptor(-/-) double knockout mouse model.

Subjects: Aging/Aging/Aging/*metabolism ; Atherosclerosis/Atherosclerosis/Atherosclerosis/*metabolism ; Spermatogenesis/Spermatogenesis/Spermatogenesis/*physiology

  • Source: International journal of andrology [Int J Androl] 2012 Aug; Vol. 35 (4), pp. 562-71. Date of Electronic Publication: 2011 Dec 13.Publisher: Blackwell Country of Publication: England NLM ID: 8000141 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2605

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Academic Journal

Centrosome misorientation reduces stem cell division during ageing.

  • Authors : Cheng J; Department of Biomedical Engineering, Center for Ultrafast Optical Science, University of Michigan, Ann Arbor, Michigan 48109, USA.; Türkel N

Subjects: Spermatogenesis*; Aging/Aging/Aging/*physiology ; Centrosome/Centrosome/Centrosome/*metabolism

  • Source: Nature [Nature] 2008 Dec 04; Vol. 456 (7222), pp. 599-604. Date of Electronic Publication: 2008 Oct 15.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

An alternative interpretation of cellular 'selfish spermatogonial selection'-clusters in the human testis indicates the need for 3-D-analyses.

  • Authors : Pohl E; Centre of Reproductive Medicine and Andrology, University Hospital Münster, Germany.; Gromoll J

Subjects: Imaging, Three-Dimensional* ; Mutation*; Aging/Aging/Aging/*pathology

  • Source: Andrology [Andrology] 2016 Mar; Vol. 4 (2), pp. 213-7. Date of Electronic Publication: 2016 Feb 19.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101585129 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Optimizing a Male Reproductive Aging Mouse Model by D-Galactose Injection.

  • Authors : Liao CH; PhD Program in Nutrition & Food Science, Fu Jen Catholic University, No. 510, Zhongzheng Road, Xinzhuang District, New Taipei City 242, Taiwan. .; Division of Urology, Department of Surgery, Cardinal Tien Hospital, No. 362, Zhongzheng Road, Xindian District, New Taipei City 231, Taiwan. .

Subjects: Aging/Aging/Aging/*drug effects ; Galactose/Galactose/Galactose/*pharmacology ; Reproduction/Reproduction/Reproduction/*drug effects

  • Source: International journal of molecular sciences [Int J Mol Sci] 2016 Jan 13; Vol. 17 (1). Date of Electronic Publication: 2016 Jan 13.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Influence of histological degree of seminiferous tubular degeneration and stage of seminiferous cycle on the proliferation of spermatogonia in aged Syrian hamster (Mesocricetus auratus).

  • Authors : Bernal-Mañas CM; Department of Cell Biology and Histology, Aging Institute, IMIB, School of Medicine, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Murcia, Spain.; Cortes S

Subjects: Aging/Aging/Aging/*pathology ; Seminiferous Tubules/Seminiferous Tubules/Seminiferous Tubules/*pathology ; Spermatogonia/Spermatogonia/Spermatogonia/*pathology

  • Source: Andrologia [Andrologia] 2014 Aug; Vol. 46 (6), pp. 672-9. Date of Electronic Publication: 2013 Jul 21.Publisher: Blackwell Pub Country of Publication: Germany NLM ID: 0423506 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Effects of male sexual maturity of reproductive endpoints relevant to DART studies in Wistar Hannover rats.

  • Authors : Takakura I; Safety Research Laboratory, R&D, Kissei Pharmaceuticals Co., Ltd.; Creasy DM

Subjects: Toxicity Tests*; Aging/Aging/Aging/*physiology ; Genitalia, Male/Genitalia, Male/Genitalia, Male/*growth & development

  • Source: The Journal of toxicological sciences [J Toxicol Sci] 2014 Apr; Vol. 39 (2), pp. 269-79.Publisher: Doku Sayō Kenkyūkai Country of Publication: Japan NLM ID: 7805798 Publication Model: Print Cited Medium: Internet ISSN: 1880-3989

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Academic Journal

Impaired function of the blood-testis barrier during aging is preceded by a decline in cell adhesion proteins and GTPases.

  • Authors : Paul C; Department of Pharmacology and Therapeutics, McGill University, Montréal, Canada.; Robaire B

Subjects: Aging/Aging/Aging/*physiology ; Blood-Testis Barrier/Blood-Testis Barrier/Blood-Testis Barrier/*physiopathology ; Cell Adhesion Molecules/Cell Adhesion Molecules/Cell Adhesion Molecules/*metabolism

  • Source: PloS one [PLoS One] 2013 Dec 31; Vol. 8 (12), pp. e84354. Date of Electronic Publication: 2013 Dec 31 (Print Publication: 2013).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Anti-aging activity of the Ink4/Arf locus.

  • Authors : Matheu A; Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Maraver A

Subjects: Aging/Aging/Aging/*genetics ; Cyclin-Dependent Kinase Inhibitor p16/Cyclin-Dependent Kinase Inhibitor p16/Cyclin-Dependent Kinase Inhibitor p16/*metabolism ; Genes, Tumor Suppressor/Genes, Tumor Suppressor/Genes, Tumor Suppressor/*physiology

  • Source: Aging cell [Aging Cell] 2009 Apr; Vol. 8 (2), pp. 152-61.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print Cited Medium: Internet ISSN: 1474-9726

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