نتائج البحث

Discovery of Novel Inhibitors against ALS-Related SOD1(A4V) Aggregation through the Screening of a Chemical Library Using Differential Scanning Fluorimetry (DSF).

• Authors : Giannakou, Maria; Akrani, Ifigeneia; Tsoka, Angeliki

• Source: Pharmaceuticals (14248247); Oct2024, Vol. 17 Issue 10, p1286, 30p

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Rutin Ameliorates ALS Pathology by Reducing SOD1 Aggregation and Neuroinflammation in an SOD1-G93A Mouse Model.

• Authors : Du, Xiaoyu; Dong, Quanxiu; Zhu, Jie

Subjects: AMYOTROPHIC lateral sclerosis; MOTOR neurons; TREATMENT effectiveness

• Source: International Journal of Molecular Sciences; Oct2024, Vol. 25 Issue 19, p10392, 13p

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GCN2 inhibition reduces mutant SOD1 clustering and toxicity and delays disease progression in an amyotrophic lateral sclerosis mouse model.

• Authors : Ortiz, Didio Alberto; Peregrín, Nuria; Valencia, Miguel

Subjects: TRANSCRIPTION factors; UNFOLDED protein response; INITIATION factors (Biochemistry)

• Source: Translational Neurodegeneration; 9/20/2024, Vol. 13 Issue 1, p1-5, 5p

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Nuclear Localization of Human SOD1 in Motor Neurons in Mouse Model and Patient Amyotrophic Lateral Sclerosis: Possible Links to Cholinergic Phenotype, NADPH Oxidase, Oxidative Stress, and DNA Damage.

• Authors : Martin, Lee J.; Koh, Shannon J.; Price, Antionette

Subjects: SINGLE-strand DNA breaks; CENTRAL nervous system; MOTOR neurons

• Source: International Journal of Molecular Sciences; Aug2024, Vol. 25 Issue 16, p9106, 25p

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MS785-MS27 Reactive Misfolded/Non-Native Zn-Deficient SOD1 Species Exhibit Cytotoxicity and Adopt Heterozygous Conformations in Motor Neurons.

• Authors : Tokuda, Eiichi; Sakashita, Yume; Tokoro, Naoya

Subjects: MOTOR neurons; CYTOTOXINS; AMYOTROPHIC lateral sclerosis

• Source: International Journal of Molecular Sciences; Jun2024, Vol. 25 Issue 11, p5603, 21p

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Novel insights into RAGE signaling pathways during the progression of amyotrophic lateral sclerosis in RAGE-deficient SOD1 G93A mice.

• Authors : Nowicka, Natalia; Zglejc-Waszak, Kamila; Juranek, Judyta

Subjects: AMYOTROPHIC lateral sclerosis; GLIAL fibrillary acidic protein; ADVANCED glycation end-products

• Source: PLoS ONE; 3/8/2024, Vol. 19 Issue 3, p1-16, 16p

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Structural insights into the modulation Of SOD1 aggregation By a fungal metabolite Phialomustin-B: Therapeutic potential in ALS.

• Authors : Unni, Sruthi; Kommu, Padmini; Aouti, Snehal

Subjects: AMYOTROPHIC lateral sclerosis; MOTOR neuron diseases; MUSCULAR atrophy

• Source: PLoS ONE; 3/6/2024, Vol. 19 Issue 3, p1-21, 21p

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Investigation of the Effects of SOD1 +35A/C and GPx-3 +1494A/G Gene Polymorphisms in Patients With Acne Vulgaris.

• Authors : Yukcu, Fulya; Akcılar, Raziye; Namdar, Nazlı Dizen

Subjects: ACNE; GENETIC polymorphisms; OXIDATIVE stress

• Source: Journal of Clinical Practice & Research; Mar2024, Vol. 46 Issue 2, p161-170, 10p

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Oxidized SOD1 accelerates cellular senescence in neural stem cells.

• Authors : Guan, Teng; Guo, Ying; Zhou, Ting

Subjects: NEURAL stem cells; CELLULAR aging; PROTEOLYSIS

• Source: Stem Cell Research & Therapy; 2/27/2024, Vol. 15 Issue 1, p1-16, 16p

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Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS.

• Authors : Hossain, Md Amin; Sarin, Richa; Donnelly, Daniel P.

Subjects: PROTEIN crosslinking; LABORATORY mice; AMYOTROPHIC lateral sclerosis

• Source: PLoS Biology; 1/30/2024, Vol. 22 Issue 1, p1-34, 34p

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