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Clinical Trial Readiness to Solve Barriers to Drug Development in FSHD (ReSolve)

• Authors : National Institute of Neurological Disorders and Stroke (NINDS); FSHD Society; Friends Research Institute, Inc.

• Source: Clinical Trial Readiness to Solve Barriers to Drug Development in FSHDLoRusso S, Johnson NE, McDermott MP, Eichinger K, Butterfield

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Biomarker Discovery for Novel Drug Development in Idiopathic Pulmonary Fibrosis

• Source: Prospective, Longitudinal Cohort Trial of Patients With Idiopathic Pulmonary Fibrosis (IPF) and Healthy Control Patients. Clinical Data, Blood, and Bronchiolavage (BAL) Fluid Will be Collected Over 12

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Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development

• Source: Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug DevelopmentMousses S,

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ETC-159 in Combination with Pembrolizumab in Advanced MSS/pMMR Ovarian Cancers (ETC-159-02)

• Authors : EDDC (Experimental Drug Development Centre), A*STAR Research Entities

• Source: A Phase 1B Investigator Initiated Study to Evaluate the Preliminary Activity, Safety and Tolerability of ETC-159 in Combination with Pembrolizumab in Advanced MSS/pMMR Ovarian Cancers.Liu J, Pan

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PK and Dose Escalation and Expansion Study of DST-2970

• Authors : Translational Drug Development

• Source: A Phase 1 PK and Dose Escalation and Expansion Study of DST-2970 in Patients With Prostate Cancer With Rising PSA on Treatment With Abiraterone Acetate

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DECOY20 Study in Patients with Advanced Solid Tumors

• Authors : Translational Drug Development

• Source: A Phase 1, Open-Label, Multi-Center, Dose Escalation and Expansion Study Evaluating the Safety, Tolerability and Clinical Activity of DECOY20 in Patients with Advanced Solid Tumors

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A Pan-TB Regimen Targeting Host and Microbe (panTB-HM)

• Authors : Ludwig-Maximilians - University of Munich; Stichting Katholieke Universiteit; Wits Health Consortium (Pty) Ltd

• Source: A Novel 4-month Pan-TB Regimen Targeting Both Host and Microbe (panTB-HM)

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Efficacy and Safety Evaluation of Two to Four Months of Treatment With the Combination Regimens of DBOS and PBOS in Adults With Pulmonary Tuberculosis

• Authors : Global Alliance for TB Drug Development; Janssen Pharmaceutica; Otsuka Pharmaceutical Co., Ltd.

• Source: A Phase 2b/c, Multi-Arm, 2-Stage, Duration Randomized Trial of the Efficacy and Safety of Two to Four Months Treatment With Regimens Containing Bedaquiline, OPC-167832, and Sutezolid, Plus Either

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De-escalation Adjuvant Chemo in HER2+/ER-/node-neg Early BC Patients Who Achieved PCR After Neoadjuvant Chemo & Dual HER2 Blockade (Decrescendo)

• Authors : Breast International Group; Hoffmann-La Roche; International Drug Development Institute

• Source: De-Escalation of Adjuvant Chemotherapy in HER2-positive, Estrogen Receptor-negative, Node-negative Early Breast Cancer Patients Who Achieved Pathological Complete Response After Neoadjuvant

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Telacebec (T) Treatment in Adults with Buruli Ulcer (BU). (TREAT-BU)

• Authors : Global Alliance for TB Drug Development

• Source: A Phase 2 Multicentre, Open-label Study to Evaluate the Efficacy, Safety and Tolerability, and Pharmacokinetics of 28 Days Telacebec Treatment in Adult Participants with Buruli Ulcer.

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