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Leveraging biomarkers and translational medicine for preclinical safety : Lessons for advancing the validation of alternatives to animal testing

• Authors : Hartung, Thomas; King, Nicholas M. P.; Kleinstreuer, Nicole

Subjects: biomarkers; translational medicine; translational research

• Source: Alternatives to Animal Experimentation : ALTEX. Springer. 2024, 41(4), S. 545-566. ISSN 1868-596X. eISSN 1868-8551. Verfügbar unter: doi:10.14573/altex.2410011

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Metabolomics in Preclinical Drug Safety Assessment : Current Status and Future Trends

• Authors : Sillé, Fenna; Hartung, Thomas

Subjects: metabolomics; toxicity; safety

• Source: Metabolites. MDPI. 2024, 14(2), 98. eISSN 2218-1989. Available under: doi:10.3390/metabo14020098

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Optimization of the TeraTox assay for preclinical teratogenicity assessment

• Authors : Jaklin, Manuela; Zhang, Jitao David; Schäfer, Nicole

Subjects: teratogenicity; molecular phenotyping; TeraTox

• Source: Toxicological Sciences. Oxford University Press (OUP). 2022, 188(1), pp. 17-33. ISSN 1096-6080. eISSN 1096-0929. Available under: doi:10.1093/toxsci/kfac046

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Look back in anger : what clinical studies tell us about preclinical work

• Authors : Hartung, Thomas

Subjects: preclinical studies; animal studies; in vitro studies

• Source: Alternatives to Animal Experimentation : ALTEX. 2013, 30(3), pp. 275-291. ISSN 0946-7785. eISSN 1868-8551. Available under: doi:10.14573/altex.2013.3.275

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t 4 report : metabolomics in toxicology and preclinical research

• Authors : Ramirez, Tzutzuy; Kamp, Hennicke; Bois, Frederic Y.

Subjects: ddc:570

• Source: ALTEX. 2013, 30(2), pp. 209-225. ISSN 1868-596X. Available under: doi:10.14573/altex.2013.2.209

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Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7

• Authors : Oosterhuis, Koen; van den Berg, Joost H.; Toebes, Mireille

Subjects: DNA vaccination; CD8+; T cells

• Source: International Journal of Cancer. 2011, 129(2), pp. 397-406. ISSN 0020-7136. eISSN 1097-0215. Available under: doi:10.1002/ijc.25894

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Optimizing drug discovery by Investigative Toxicology : Current and future trends

• Authors : Beilmann, Mario; Boonen, Harrie; Czich, Andreas

Subjects: ddc:570

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Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases

• Authors : Berger, Nathan A; Besson, Valerie C; Boulares, A Hamid

Subjects: ddc:570

• Source: British journal of pharmacology. 2018, 175(2), pp. 192-222. ISSN 0366-0826. eISSN 1476-5381. Available under: doi:10.1111/bph.13748

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On the Role of the Immunoproteasome in Protein Homeostasis

• Authors : Basler, Michael; Gröttrup, Marcus

Subjects: ddc:570

• Source: Cells. MDPI. 2021, 10(11), 3216. eISSN 2073-4409. Available under: doi:10.3390/cells10113216

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PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy

• Authors : Körner, Julia; Horvath, Dennis; Herrmann, Valerie L.

Subjects: ddc:570

• Source: Nature Communications. Nature Publishing Group. 2021, 12(1), 2935. eISSN 2041-1723. Available under: doi:10.1038/s41467-021-23244-3

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