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Combining Homologous Recombination-Deficient Testing and Functional RAD51 Analysis Enhances the Prediction of Poly(ADP-Ribose) Polymerase Inhibitor Sensitivity

• Authors : Korsholm, Lea M.; Kjeldsen, Maj; Perino, Lorenzo

• Source: Korsholm , L M , Kjeldsen , M , Perino , L , Mariani , L , Nyvang , G B , Kristensen , E , Bagger , F O , Mirza , M R & Rossing , M 2024 , ' Combining Homologous Recombination-Deficient Testing and

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Rucaparib or Physician's Choice in Metastatic Prostate Cancer

Subjects: Humans; Male; Antineoplastic Combined Chemotherapy Protocols/therapeutic use

• Source: TRITON3 Investigators 2023 , ' Rucaparib or Physician's Choice in Metastatic Prostate Cancer ' , The New England Journal of Medicine , vol. 388 , no. 8 , pp. 719-732 .

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Rucaparib for the Treatment of Metastatic Castration-resistant Prostate Cancer Associated with a DNA Damage Repair Gene Alteration:Final Results from the Phase 2 TRITON2 Study

• Authors : Abida, Wassim; Campbell, David; Patnaik, Akash

Subjects: DNA damage repair gene alteration; Metastatic castration-resistant prostate cancer; Poly(ADP-ribose) polymerase inhibitor

• Source: Abida , W , Campbell , D , Patnaik , A , Bryce , A H , Shapiro , J , Bambury , R M , Zhang , J , Burke , J M , Castellano , D , Font , A , Ganju , V , Hardy-Bessard , A C , McDermott , R , Sautois , B

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Coronavirus infection and PARP expression dysregulate the NAD metabolome:An actionable component of innate immunity

• Authors : Heer, Collin D.; Sanderson, Daniel J.; Voth, Lynden S.

Subjects: Severe acute respiratory syndrome coronavirus 2; transcriptomics; interferon

• Source: Heer , C D , Sanderson , D J , Voth , L S , Alhammad , Y M O , Schmidt , M S , Trammell , S A J , Perlman , S , Cohen , M S , Fehr , A R & Brenner , C 2020 , ' Coronavirus infection and PARP

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The regulatory landscape of the human HPF1-and ARH3-dependent ADP-ribosylome

• Authors : Hendriks, Ivo A.; Buch-Larsen, Sara C.; Prokhorova, Evgeniia

Subjects: ACETYLATION POSTTRANSLATIONAL MODIFICATIONS; POLY(ADENOSINE DIPHOSPHATE RIBOSYLATION); DNA-DAMAGE RESPONSE

• Source: Hendriks , I A , Buch-Larsen , S C , Prokhorova , E , Elsborg , J D , Rebak , A K L F S , Zhu , K , Ahel , D , Lukas , C , Ahel , I & Nielsen , M L 2021 , ' The regulatory landscape of the human

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Implementing MyChoice® CDx HRD testing for the Nordics:lessons from 2021 to 2023

• Authors : Korsholm, Lea Milling; Broecker, Verena; Mirza, Mansoor Raza

Subjects: biomarker; BRCA; cancer

• Source: Korsholm , L M , Broecker , V , Mirza , M R & Rossing , M 2024 , ' Implementing MyChoice® CDx HRD testing for the Nordics : lessons from 2021 to 2023 ' , Acta Oncologica , vol. 63 , pp. 70-75 .

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ADP-ribosylome analysis reveals homogeneous DNA-damage-induced serine ADP-ribosylation across wild-type and BRCA-mutant breast cancer cell lines

• Authors : Anagho, Holda Awah; Mullari, Meeli; Prósz, Aurél György

Subjects: ADP-ribosylation; ADP-ribosylome; Af1521 macrodomain

• Source: Anagho , H A , Mullari , M , Prósz , A G , Buch-Larsen , S C , Cho , H , Locard-Paulet , M , Szallasi , Z & Nielsen , M L 2024 , ' ADP-ribosylome analysis reveals

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Functional annotation of variants of the BRCA2 gene via locally haploid human pluripotent stem cells

• Authors : Li, Hanqin; Bartke, Rebecca; Zhao, Lei

• Source: Li , H , Bartke , R , Zhao , L , Verma , Y , Horacek , A , Rechav Ben-Natan , A , Pangilinan , G R , Krishnappa , N , Nielsen , R & Hockemeyer , D 2024 , ' Functional annotation of variants of the

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H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours

• Authors : Dibitetto, Diego; Liptay, Martin; Vivalda, Francesca

• Source: Dibitetto , D , Liptay , M , Vivalda , F , Dogan , H , Gogola , E , González Fernández , M , Duarte , A , Schmid , J A , Decollogny , M , Francica , P , Przetocka , S , Durant , S T , Forment , J V

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ATM deficiency confers specific therapeutic vulnerabilities in bladder cancer

• Authors : Zhou, Yuzhen; Börcsök, Judit; Adib, Elio

• Source: Zhou , Y , Börcsök , J , Adib , E , Kamran , S C , Neil , A J , Stawiski , K , Freeman , D , Stormoen , D R , Sztupinszki , Z , Samant , A , Nassar , A , Bekele , R T , Hanlon , T , Valentine , H ,

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