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Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors

• Authors : Beetham, Henry; Griffith, Billie G. C.; Murina, Olga

Subjects: Aniline Compounds/pharmacology; Animals; Breast Neoplasms/enzymology

• Source: Beetham , H , Griffith , B G C , Murina , O , Loftus , A E P , Parry , D A , Temps , C , Culley , J , Muir , M , Unciti-Broceta , A , Sims , A H , Byron , A & Brunton , V G 2022 , ' Loss of

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The paradox-breaking panRAF plus SRC family kinase inhibitor, CCT3833, is effective in mutant KRAS-driven cancers

• Authors : Saturno, Grazia; Lopes, Filipa; Niculescu-Duvaz, I

Subjects: KRAS; panRAF/SRC inhibitor; CRC

• Source: Saturno , G , Lopes , F , Niculescu-Duvaz , I , Niculescu-Duvaz , D , Zambon , A , Davies , L , Johnson , L , Preece , N , Lee , R , Viros Usandizaga , A , Holovanchuk , D , Pedersen , M , Mcleary , R

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Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition

• Authors : Horton, Edward R.; Humphries, Jonathan D; Stutchbury, Benjamin

Subjects: Animals; Cell Adhesion; Cell Movement

• Source: Horton , E R , Humphries , J D , Stutchbury , B , Jacquemet , G , Ballestrem , C , Barry , S T & Humphries , M J 2016 , ' Modulation of FAK and Src adhesion signaling

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Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks

• Authors : Schoenherr, Christina; Byron, Adam; Sandilands, Emma

• Source: Schoenherr , C , Byron , A , Sandilands , E , Paliashvili , K , Baillie , G S , Garcia-Munoz , A , Valacca , C , Cecconi , F , Serrels , B & Frame , M C 2017 , ' Ambra1 spatially regulates

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v-Src oncogene induces Trop2 proteolytic activation via cyclin D1

• Authors : Ju, Xiaoming; Jiao, Xuanmao; Ertel, Adam

Subjects: ResearchInstitutes_Networks_Beacons/mcrc; Manchester Cancer Research Centre

• Source: Ju , X , Jiao , X , Ertel , A , Casimiro , M C , Di Sante , G , Deng , S , Li , Z , Di Rocco , A , Zhan , T , Hawkins , A , Stoyanova , T , Andò , S , Fatatis , A , Lisanti , M P , Gomella , L G ,

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p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK signalling

• Authors : Srivastava, Kirtiman; Pickard, Adam; McDade, Simon

Subjects: Journal Article

• Source: Srivastava , K , Pickard , A , McDade , S & McCance , D J 2015 , ' p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK

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Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma.

• Authors : Girotti, Maria Romina; Lopes, Filipa; Preece, Natasha

Subjects: ResearchInstitutes_Networks_Beacons/mcrc; Manchester Cancer Research Centre

• Source: Girotti , MR , Lopes , F , Preece , N , Niculescu-Duvaz , D , Zambon , A , Davies , L , Whittaker , S , Saturno , G , Viros , A , Pedersen , M , Suijkerbuijk , BM J M , Menard , D , McLeary , R ,

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The interaction of p130Cas with PKN3 promotes malignant growth

• Authors : Gemperle, Jakub; Dibus, Michal; Koudelkova, Lenka

Subjects: BCAR1; CAS; p130Cas

• Source: Gemperle , J , Dibus , M , Koudelkova , L , Rosel , D & Brabek , J 2019 , ' The interaction of p130Cas with PKN3 promotes malignant growth ' , Molecular Oncology , vol. 13 , no. 2 , pp. 264-289 .

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Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners

• Authors : Gemperle, Jakub; Hexnerova, Rozlie; Lepsik, Martin

Subjects: Src; SH3; p130Cas

• Source: Gemperle , J , Hexnerova , R , Lepsik , M , Tesina , P , Dibus , M , Novotny , M , Brabek , J , Veverka , V & Rosel , D 2017 , ' Structural characterization of CAS SH3 domain selectivity and

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Caveolin mediates rapid glucocorticoid effects and couples glucocorticoid action to the antiproliferative program

• Authors : Matthews, L.; Berry, A.; Ohanian, V.

Subjects: metabolism: 1-Phosphatidylinositol 3-Kinase; Animals; metabolism: Caveolin 1

• Source: Matthews , L , Berry , A , Ohanian , V , Ohanian , J , Garside , H & Ray , D 2008 , ' Caveolin mediates rapid glucocorticoid effects and couples glucocorticoid action to the antiproliferative program

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