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Academic Journal

RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling

Subjects: Signal Transduction; Cell Membrane - metabolism; Lipopolysaccharides - metabolism

  • Source: Knopf , J D , Steigleder , S S , Korn , F , Kühnle , N , Badenes , M , Tauber , M , Theobald , S J , Rybniker , J , Adrain , C & Lemberg , M K 2024 , ' RHBDL4-triggered downregulation of COPII

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Academic Journal

USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF

Subjects: Humans; Vascular Endothelial Growth Factor A; Immune Checkpoint Inhibitors/pharmacology

  • Source: Jurisic , A , Sung , P-J , Wappett , M , Daubriac , J , Lobb , I T , Kung , W-W , Crawford , N , Page , N , Cassidy , E , Feutren-Burton , S , Rountree , J S S , Helm , M D , O'Dowd , C R , Kennedy ,

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Academic Journal

The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect TRAIL-mediated apoptosis

Subjects: Cisplatin; Cholesterol; Cytochromes c

  • Source: Holloway , J , Seeley , A , Cobbe , N , Turkington , R C , Longley , D B & Evergren , E 2024 , ' The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect

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Academic Journal

Effects of PROtein enriched MEDiterranean Diet and EXercise on nutritional status and cognition in adults at risk of undernutrition and cognitive decline: the PROMED-EX Randomised Controlled Trial

Subjects: Humans; Middle Aged; Aged

  • Source: Ward , N A , Reid-McCann , R , Brennan , L , Cardwell , C R , de Groot , CPGM , Maggi , S , McCaffrey , N , McGuinness , B , McKinley , M C , Noale , M , O'Neill , R F , Prinelli , F , Sergi , G ,

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Academic Journal

A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection

Subjects: Cullin Proteins - metabolism; Immunity; Innate

  • Source: Sá-Pessoa , J , López-Montesino , S , Przybyszewska , K , Rodríguez-Escudero , I , Marshall , H , Ova , A , Schroeder , G N , Barabas , P , Molina , M , Curtis , T , Cid , V J & Bengoechea , J A

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Academic Journal

Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143/145

Subjects: Humans; Animals; Mice

  • Source: Wade , H , Pan , K , Duan , Q , Kaluzny , S , Pandey , E , Fatumoju , L , Saraswathi , V , Wu , R , Harris , E N & Su , Q 2023 , ' Akkermansia muciniphila and its membrane protein ameliorates

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Academic Journal

Oxidation modulates LINGO2-induced inactivation of large conductance, Ca2 + -activated potassium channels

Subjects: LINGO subunits; Potassium channel; biophysics

  • Source: Dudem , S , Boon , P X , Mullins , N , McClafferty , H , Shipston , M J , Wilkinson , R D A , Lobb , I , Sergeant , G P , Thornbury , K D , Tikhonova , I G & Hollywood , M A 2023 , ' Oxidation

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Academic Journal

Gα q signalling from endosomes: a new conundrum

Subjects: endocytosis; phosphoinositides; membrane lipids

  • Source: Daly , C & Plouffe , B 2023 , ' Gα q signalling from endosomes: a new conundrum ' , British Journal of Pharmacology . https://doi.org/10.1111/bph.16248

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Academic Journal

The effect of animal versus plant protein on muscle mass, muscle strength, physical performance and sarcopenia in adults: protocol for a systematic review

Subjects: Aged; Animal protein; Animals

  • Source: Reid-McCann , R J , Brennan , S F , McKinley , M C & McEvoy , C T 2022 , ' The effect of animal versus plant protein on muscle mass, muscle strength, physical performance and sarcopenia in adults:

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Academic Journal

Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis

Subjects: brain tumors; glioblastoma; gliomagenesis

  • Source: Giannopoulou , A I , Xanthopoulos , C , Piperi , C & Kostareli , E 2022 , ' Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis ' , Cancers , vol. 14 , no. 18

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Academic Journal

Peripheral amino acid appearance is lower following plant protein fibre products, compared to whey protein and fibre ingestion, in healthy older adults despite optimised amino acid profile

Subjects: Digestibility; Plant protein; Fibre

  • Source: de Marco Castro , E , Valli , G , Buffière , C , Guillet , C , Mullen , B , Pratt , J , Horner , K , Naumann-Gola , S , Bader-Mittermaier , S , Paganini , M , De Vito , G , Roche , H M & Dardevet , D

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Academic Journal

RNA-Binding Proteins: Emerging Therapeutics for Vascular Dysfunction

Subjects: Humans; Cardiovascular Diseases - metabolism; Induced Pluripotent Stem Cells - metabolism

  • Source: Cornelius , V A , Naderi-Meshkin , H , Kelaini , S & Margariti , A 2022 , ' RNA-Binding Proteins: Emerging Therapeutics for Vascular Dysfunction ' , Cells , vol. 11 ,

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Book

Exploring molecular mechanisms within biomedical literature

Subjects: Data Mining - methods; Databases; Factual

  • Source: Glendinning , N , Hawthorne , C , Beck , S & Lopez-Campos , G 2022 , Exploring molecular mechanisms within biomedical literature . in P Otero , P Scott , S Z Martin & E Huesing (eds) , MEDINFO 2021:

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Academic Journal

An innovative food system approach to diversifying protein intake: Protein-I: Shared Island sustainable healthy nutrition

Subjects: Diet; Healthy; Nutritional Status

  • Source: Brennan , L , O'Gorman , A , Barth , S , Cadden , T , Dean , M , Doohan , F , Henchion , M , McIvor , R , McNulty , B , O'Donoghue , C , O'Reilly , S , Rafferty , J , Roche , H M , Thorne , F ,

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Academic Journal

Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids

Subjects: Chromatin; Fibrosis; Humans

  • Source: Davis , J L , Kennedy , C , Clerkin , S , Treacy , N J , Dodd , T , Moss , C , Murphy , A , Brazil , D P , Cagney , G , Brougham , D F , Murad , R , Finlay , D , Vuori , K & Crean , J 2022 , '

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Academic Journal

Baseline plasma IL-18 may predict simvastatin treatment response in patients with ARDS: a secondary analysis of the HARP-2 randomised clinical trial

Subjects: Interleukin-18; Simvastatin; Acute respiratory distress syndrome

  • Source: Boyle , A J , Ferris , P , Bradbury , I , Conlon , J , Shankar-Hari , M , Rogers , A J , O'Kane , C M & McAuley , D F 2022 , ' Baseline plasma IL-18 may predict simvastatin treatment response in

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Academic Journal

Automated prediction of site and sequence of protein modification with ATRP initiators

Subjects: Bromine; Esters; Lysine

  • Source: Patel , A , Smith , P N , Russell , A J & Carmali , S 2022 , ' Automated prediction of site and sequence of protein modification with ATRP initiators ' , PLOS ONE , vol. 17 , no. 9 , e0274606 .

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Academic Journal

Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development

Subjects: Tamoxifen; Angiogenesis Inhibitors; Serine

  • Source: Page , N , Wappett , M , O'Dowd , C R , O'Rourke , M , Gavory , G , Zhang , L , Rountree , J S S , Jordan , L , Barker , O , Gibson , H , Boyd , C , Feutren-Burton , S , McLean , E , Trevitt , G &

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Academic Journal

The present and future role of microfluidics for protein and peptide-based therapeutics and diagnostics

Subjects: Drug Delivery; Nanomedicine; Nanotechnology

  • Source: Weaver , E , Uddin , S , Cole , D K , Hooker , A & Lamprou , D A 2021 , ' The present and future role of microfluidics for protein and peptide-based therapeutics and diagnostics ' , Applied Sciences ,

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Academic Journal

Key Genes of Lipid Metabolism and WNT-Signaling Are Downregulated in Subcutaneous Adipose Tissue with Moderate Weight Loss

Subjects: Adult; Aged; Caloric Restriction/methods

  • Source: Schübel , R , Sookthai , D , Greimel , J , Johnson , T S , Grafetstätter , M E , Kirsten , R , Kratz , M , Ulrich , C M , Kaaks , R & Kühn , T 2019 , ' Key Genes of Lipid Metabolism and

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Academic Journal

Comprehensive proteomics investigation of P. vivax-infected human plasma and parasite isolates

Subjects: Gene Ontology; Host-Parasite Interactions/physiology; Humans

  • Source: Venkatesh , A , Aggarwal , S , Kumar , S , Rajyaguru , S , Kumar , V , Bankar , S , Shastri , J , Patankar , S & Srivastava , S 2020 , ' Comprehensive proteomics investigation of P. vivax-infected

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Academic Journal

Insights into the skin of caecilian amphibians from gene expression profiles

Subjects: Bioactive peptides; Claudins; Cornified proteins

  • Source: Torres-Sánchez , M , Wilkinson , M , Gower , D J , Creevey , C J & San Mauro , D 2020 , ' Insights into the skin of caecilian amphibians from gene expression profiles ' , BMC Genomics , vol. 21 , no.

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Academic Journal

Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins

Subjects: Acetylation; Cell Cycle Proteins/genetics; Chromatin Immunoprecipitation

  • Source: Hoggard , T A , Chang , F , Perry , K R , Subramanian , S , Kenworthy , J , Chueng , J , Shor , E , Hyland , E M , Boeke , J D , Weinreich , M & Fox , C A 2018 , ' Yeast heterochromatin regulators

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