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  • 1-8 ل  8 نتائج ل ""Dihydropyrimidine Dehydrogenase""
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Academic Journal

Potential added value of combined DPYD/DPD genotyping and phenotyping to prevent severe toxicity in patients with a DPYD variant and decreased dihydropyrimidine dehydrogenase enzyme activity

Subjects: DPYD; DPD; DPD deficiency

  • Source: Ockeloen , C W , Raaijmakers , A , Hijmans-van der Vegt , M , Bierau , J , de Vos-Geelen , J , Willemsen , A E C A B , van den Bosch , B J C & Coenen , M J H 2021 , ' Potential added value of combined

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Academic Journal

Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers

Subjects: 5-fluorouracil; capecitabine; circadian rhythm

  • Source: Jacobs , B A W , Deenen , M J , Pluim , D , van Hasselt , J G C , Krahenbuhl , M D , van Geel , R M J M , de Vries , N , Rosing , H , Meulendijks , D , Burylo , A M , Cats , A , Beijnen , J H ,

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Academic Journal

Evolution of Dihydropyrimidine Dehydrogenase Diagnostic Testing in a Single Center during an 8-Year Period of Time

Subjects: Dehydrogenase; Dihydropyrimidine genetic variant; Fluoropyrimidine

  • Source: Coenen , M J H , Paulussen , A D C , Breuer , M , Lindhout , M , Tserpelis , D C J , Steyls , A , Bierau , J & van den Bosch , B J C 2019 , ' Evolution of

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Academic Journal

Discovering novel germline genetic variants linked to severe fluoropyrimidine-related toxicity in- and outside DPYD

Subjects: Fluoropyrimidines; Pharmacogenetics; Personalized medicine

  • Source: Knikman , J E , Zhai , Q , Lunenburg , C A T C , Henricks , L M , Boehringer , S , van der Lee , M , de Man , F M , Offer , S M , Shrestha , S , Creemers , G-J , Baars , A , Dezentje , V O , Imholz ,

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Academic Journal

β-Ureidopropionase deficiency due to novel and rare UPB1 mutations affecting pre-mRNA splicing and protein structural integrity and catalytic activity

Subjects: ALANINE SYNTHASE; AMINOISOBUTYRIC ACID; CARNOSINE

  • Source: Dobritzsch , D , Meijer , J , Meinsma , R , Maurer , D , Monavari , A A , Gummesson , A , Reims , A , Cayuela , J A , Kuklina , N , Benoist , J-F , Perrin , L , Assmann , B , Hoffmann , G F , Bierau ,

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Academic Journal

Severe fluoropyrimidine toxicity due to novel and rare DPYD missense mutations, deletion and genomic amplification affecting DPD activity and mRNA splicing

Subjects: Dihydropyrimidine dehydrogenase; DPYD; 5-Fluorouracil

  • Source: van Kuilenburg , A B P , Meijer , J , Maurer , D , Dobritzsch , D , Meinsma , R , Los , M , Knegt , L C , Zoetekouw , L , Jansen , R L H , Dezentje , V , van Huis-Tanja , L H , van Kampen , R J W ,

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Academic Journal

Next-Generation Sequencing in Oncology:Genetic Diagnosis, Risk Prediction and Cancer Classification

Subjects: next-generation sequencing; whole-exome-sequencing; whole-genome-sequencing

  • Source: Kamps , R , Brandao , R D , van den Bosch , B J , Paulussen , A D C , Xanthoulea , S , Blok , M J & Romano , A 2017 , ' Next-Generation Sequencing in Oncology : Genetic Diagnosis, Risk Prediction and

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  • 1-8 ل  8 نتائج ل ""Dihydropyrimidine Dehydrogenase""