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Collection : Elife (E-Journal - Via Crossref)

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Figure 1. Incidence and prevalence of malaria as a function of age. ; (a) and prevalence of asymptomatic parasitemia (b) in the three study sites as a function of age, modeled using generalized additive models (GAMS). Shaded areas represent 95% confidence bounds.

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Figure 5—figure supplement 7. Limiting the analysis to ‘incident’ infections. ; Since we don’t have data on the genotypes of parasites, it is also possible that consecutive asymptomatic infections represent persistent, rather than new infections. To assess the potential impact of including these persistent infections in the analyses, we conducted sensitivity analyses where we limited the dataset to ‘incident’ infections. We considered the following samples as belonging to ‘Incident’ infections. All instances of symptomatic malaria infection not preceded by an asymptomatic infection within 10 days. All instances of asymptomatic infection when. The previous blood smear (from routine or active surveillance) was negative. The previous blood smear (from routine surveillance) was positive, but the participant received malaria treatment between that visit and the current one. Limiting the analyses to incident infections implied excluding 700/1431 instances of asymptomatic parasitemia. Figure shows results of models quantifying anti-parasite (left) and anti-disease immunity (right). Left panel shows expected parasite densities (log 10, parasites/μL) after infection at different ages and levels of exposure (aEIR). Right panel shows the expected fever thresholds (parasite densities required to develop a temperature 38°C or greater). These results are similar to those presented in Figure 5, but limiting the dataset to ‘incident’ infections.

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