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Academic Journal

Log D7.4 and plasma protein binding of synthetic cannabinoid receptor agonists and a comparison of experimental and predicted lipophilicity

Subjects: lipophilicity; new psychoactive substances; pharmacokinetics

  • Source: Brandon, A M, Baginski, S R, Peet, C, Dugard, P, Green, H, Sutcliffe, O B, Daéid, N N, Nisbet, L A, Read, K D & McKenzie, C 2023, 'Log D7.4 and plasma protein

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Academic Journal

Local Sensing of Absolute Refractive Index During Protein-Binding using Microlasers with Spectral Encoding

Subjects: Immunoassays; Microfluidics; Microlasers

  • Source: Caixeiro, S, Kunstmann-Olsen, C, Schubert, M, Hill, J, Barnard, I R M, Simmons, M D, Johnson, S & Gather, M C 2023, 'Local Sensing of Absolute Refractive Index During

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Academic Journal

Non-random distribution of deleterious mutations in the DNA and protein-binding domains of IRF6 are associated with Van Der Woude syndrome

Subjects: Combined Annotation Dependent Depletion score; Popliteal pterygium syndrome; Van der Woude syndrome

  • Source: Alade, A A, Buxo-Martinez, C J, Mossey, P A, Gowans, L J J, Eshete, M A, Adeyemo, W L, Naicker, T, Awotoye, W A, Adeleke, C, Busch, T, Toraño, A M, Bello, C A, Soto, M, Soto, M, Ledesma, R, Marquez,

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Academic Journal

Unravelling the druggability and immunological roles of the SOCS-family proteins

Subjects: Humans; Suppressor of Cytokine Signaling Proteins/metabolism; Animals

  • Source: Lynch, D M, Forrester, B, Webb, T & Ciulli, A 2024, 'Unravelling the druggability and immunological roles of the SOCS-family proteins', Frontiers in Immunology, vol. 15, 1449397.

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Academic Journal

Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans

Subjects: Ubiquitin-Protein Ligases/metabolism; Humans; Phosphorylation

  • Source: Lenka, D R, Dahe, S V, Antico, O, Sahoo, P, Prescott, A R, Muqit, M M K & Kumar, A 2024, 'Additional feedforward mechanism of Parkin activation via binding of

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Academic Journal

An in vitro study to determine the impact of lipid emulsion on partitioning of a broad spectrum of drugs associated with overdose

Subjects: drug overdose; drug partition; intralipid therapy

  • Source: Barker, K, Stewart, M, Rutter, A, Whitfield, P D & Megson, I L 2024, 'An in vitro study to determine the impact of lipid emulsion on partitioning of a broad spectrum of drugs associated with

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Academic Journal

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

Subjects: Protein Kinases/metabolism; Humans; Mitochondrial Precursor Protein Import Complex Proteins/metabolism

  • Source: Raimi, O G, Ojha, H, Ehses, K, Dederer, V, Lange, S M, Rivera, C P, Deegan, T D, Chen, Y, Wightman, M, Toth, R, Labib, K P M, Mathea, S, Ranson, N, Fernández-Busnadiego, R & Muqit, M M K 2024,

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Academic Journal

Structure of UBE2K-Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension

Subjects: Polyubiquitin/metabolism; Protein Binding; Protein Domains

  • Source: Nakasone, M A, Majorek, K A, Gabrielsen, M, Sibbet, G J, Smith, B O & Huang, D T 2022, 'Structure of UBE2K-Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension', Nature Chemical Biology,

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Academic Journal

Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by ilimaquinone

Subjects: Journal Article; Mycobacterium tuberculosis shikimate kinase; Shikimate‑3‑phosphate

  • Source: Simithy, J, Fuanta, N R, Hobrath, J V, Kochanowska-Karamyan, A, Hamann, M T, Goodwin, D C & Calderón, A I 2018, 'Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by

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