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Deep proteomic analysis of microglia reveals fundamental biological differences between model systems

• Authors : Lloyd, Amy; Martinez-Muriana, Anna; Davis, Emma

Subjects: Microglia; proteomics; mass spectrometry

• Source: Lloyd, A, Martinez-Muriana, A, Davis, E, Daniels, M JD, Hou, P, Mancuso, R, Murillo, A J, Sinclair, L V, Geric, I, Snellinx, A, Craessaerts, K, Theys, T, De Strooper, B & Howden, A 2024, 'Deep

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The proteomic landscape of microglia in health and disease

• Authors : Davis, Emma; Lloyd, Amy

Subjects: microglia; neuroscience; neurodegeneration

• Source: Davis, E & Lloyd, A 2024, 'The proteomic landscape of microglia in health and disease', Frontiers in Cellular Neuroscience, vol. 18, 1379717.

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Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8

• Authors : Tzioras, Makis; Daniels, Michael J. D.; Davies, Caitlin

Subjects: Alzheimer’s disease; astrocytes; microglia

• Source: Tzioras, M, Daniels, M J D, Davies, C, Baxter, P, King, D, McKay, S, Varga, B, Popovic, K, Hernandez, M, Stevenson, A J, Barrington, J, Drinkwater, E, Borella, J, Holloway, R K, Tulloch, J, Moss, J,

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Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration

• Authors : Banerjee, Poulomi; Mehta, Arpan R.; Nirujogi, Raja

Subjects: Humans; Amyotrophic Lateral Sclerosis/genetics; Frontotemporal Dementia/genetics

• Source: Banerjee, P, Mehta, A R, Nirujogi, R, Cooper, J, James, O G, Nanda, J, Longden, J, Burr, K, Salzinger, A, Paza, E, Newton, J, Story, D, Pal, S, Smith, C, Alessi, D, Selvaraj, B T, Priller, J &

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TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

• Authors : Paolicelli, Rosa C; Jawaid, Ali; Henstridge, Christopher M.

Subjects: TDP-43; Tardbp; Microglia

• Source: Paolicelli , R C , Jawaid , A , Henstridge , C M , Valeri , A , Merlini , M , Robinson , J L , Lee , E B , Rose , J , Appel , S , Lee , V M-Y , Trojanowski , J Q , Spires-Jones , T , Schulz , P E &

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Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration

• Authors : Banerjee, Poulomi; Mehta, Arpan; Nirujogi, Raja

• Source: Banerjee , P , Mehta , A , Nirujogi , R , Cooper , J , James , O G , Nanda , J , Longden , J , Burr , K , Salzinger , A , Paza , E , Newton , J , Story , D , Pal , S , Smith , C , Alessi , D ,

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Siglec-H is a microglia-specific marker that discriminates microglia from CNS-associated macrophages and CNS-infiltrating monocytes

• Authors : Konishi, Hiroyuki; Kobayashi, Masaaki; Kunisawa, Taikan

Subjects: Allodynia; Choroid plexus; DAP12

• Source: Konishi, H, Kobayashi, M, Kunisawa, T, Imai, K, Sayo, A, Malissen, B, Crocker, P R, Sato, K & Kiyama, H 2017, 'Siglec-H is a microglia-specific marker that discriminates

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Central nervous system regeneration is driven by microglia necroptosis and repopulation

• Authors : Lloyd, Amy F.; Davies, Claire L.; Holloway, Rebecca K.

Subjects: /dk/atira/pure/subjectarea/asjc/2800/2800; name=General Neuroscience

• Source: Lloyd , A F , Davies , C L , Holloway , R K , Labrak , Y , Ireland , G , Carradori , D , Dillenburg , A , Borger , E , Soong , D , Richardson , J C , Kuhlmann , T , Williams , A , Pollard , J W , des

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APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease

• Authors : Jackson, Rosemary J.; Keiser, Megan S.; Meltzer, Jonah C.

Subjects: AAV; Alzheimer disease; APOE

• Source: Jackson, R J, Keiser, M S, Meltzer, J C, Fykstra, D P, Dierksmeier, S E, Hajizadeh, S, Kreuzer, J, Morris, R, Melloni, A, Nakajima, T, Tecedor, L, Ranum, P T, Carrell, E, Chen, Y H, Nishtar, M A,

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The γ-secretase substrate proteome and its role in cell signaling regulation

• Authors : Hou, Pengfei; Zielonka, Magdalena; Serneels, Lutgarde

Subjects: Mice; Animals; Humans

• Source: Hou, P, Zielonka, M, Serneels, L, Martinez-Muriana, A, Fattorelli, N, Wolfs, L, Poovathingal, S, T'Syen, D, Balusu, S, Theys, T, Fiers, M, Mancuso, R, Howden, A J M & De Strooper, B 2023, 'The

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