نتائج البحث

High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma

• Authors : Arang, Nadia; Lubrano, Simone; Ceribelli, Michele

Subjects: melanoma; GNAQ; chemogenetic drug screening

• Source: Arang , N , Lubrano , S , Ceribelli , M , Rigiracciolo , D C , Saddawi-Konefka , R , Faraji , F , Ramirez , S I , Kim , D , Tosto , F A , Stevenson , E , Zhou , Y , Wang , Z , Bogomolovas , J ,

تفاصيل العنوان

Drug screening to identify compounds to act as co-therapies for the treatment of Burkholderia species

• Authors : Barker, Sam; Harding, Sarah V.; Gray, David

Subjects: /dk/atira/pure/subjectarea/asjc/1300/1300; name=General Biochemistry,Genetics and Molecular Biology; /dk/atira/pure/subjectarea/asjc/1100/1100

• Source: Barker , S , Harding , S V , Gray , D , Richards , M I , Atkins , H S & Harmer , N J 2021 , ' Drug screening to identify compounds to act

تفاصيل العنوان

Scaffold-free, size-controlled generation of spheroids for biochemical assays, drug screening and high-content imaging:Protocol

• Authors : Madsen, Ralitsa

• Source: Madsen , R 2022 , Scaffold-free, size-controlled generation of spheroids for biochemical assays, drug screening and high-content imaging :

تفاصيل العنوان

In vitro modeling of hepatocellular carcinoma niche on decellularized tomato thorny leaves:a novel natural three-dimensional (3D) scaffold for liver cancer therapeutics

• Authors : Ahmadian, Mariye; Hosseini, Saadi; Alipour, Atefeh

Subjects: Liver cancer modeling; Tumor Microenvironment; 3D culture

• Source: Ahmadian , M , Hosseini , S , Alipour , A , Jahanfar , M , Farrokhi , N , Homaeigohar , S & Shahsavarani , H 2023 , ' In vitro modeling of hepatocellular carcinoma niche on decellularized tomato

تفاصيل العنوان

The Tuberculosis Drug Accelerator at year 10:what have we learned?

• Authors : Aldridge, Bree B.; Barros-Aguirre, David; Barry, Clifton E.

Subjects: Bacterial infection; Drug development; Drug screening

• Source: Aldridge , B B , Barros-Aguirre , D , Barry , C E , Bates , R H , Berthel , S J , Boshoff , H I , Chibale , K , Chu , X-J , Cooper , C B , Dartois , V , Duncan , K , Fotouhi , N , Gusovsky , F ,

تفاصيل العنوان

High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

• Authors : Torrente Fernandez, Laura; Maan, Gunjit; Rezig, Asma Oumkaltoum

Subjects: NRF2; colorectal cancer; drug screening

• Source: Torrente Fernandez , L , Maan , G , Rezig , A O , Quinn , J , Jackson , A , Grilli , A , Casares , L , Zhang , Y , Kulesskiy , E , Saarela , J , Bicciato , S , Edwards , J , Dinkova-Kostova , A & de

تفاصيل العنوان

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay

• Authors : Zmuda, Filip; Sastry, Lalitha; Shepherd, Sharon M.

Subjects: Assay development; Chagas' disease; Drug discovery

• Source: Zmuda , F , Sastry , L , Shepherd , S M , Jones , D , Scott , A , Craggs , P D , Cortes , A , Gray , D W , Torrie , L S & De Rycker , M 2019 , ' Identification of Novel Trypanosoma cruzi Proteasome

تفاصيل العنوان

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

• Authors : Nakazawa Hewitt, Stephen; Dranow, David M.; Horst, Benjamin G.

Subjects: Plasmodium falciparum; drug screening; prolyl-tRNA-synthetase

• Source: Nakazawa Hewitt , S , Dranow , D M , Horst , B G , Abendroth , J A , Forte , B , Hallyburton , I , Jansen , C , Baragana , B , Choi , R , Rivas , K , Hulverson , M A , Dumais , M , Edwards , T E ,

تفاصيل العنوان

A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing

• Authors : Hassan, Sakinah; Purdie, Karin J.; Wang, Jun

Subjects: Cutaneous; In vitro; Keratinocytes

• Source: Hassan , S , Purdie , K J , Wang , J , Harwood , C A , Proby , C M , Pourreyron , C , Mladkova , N , Nagano , A , Dhayade , S , Athineos , D , Caley , M , Mannella , V , Blyth , K , Inman , G J &

تفاصيل العنوان

Challenges and opportunities in the development of novel antimicrobial therapeutics for cystic fibrosis

• Authors : Barton, Thomas E; Frost, Frederick; Fothergill, Joanne L

Subjects: Humans; Cystic Fibrosis/complications; Anti-Bacterial Agents/therapeutic use

• Source: Barton , T E , Frost , F , Fothergill , J L & Neill , D R 2022 , ' Challenges and opportunities in the development of novel antimicrobial therapeutics for cystic fibrosis ' , Journal of Medical

تفاصيل العنوان