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Academic Journal

An investigation of the clinical impact and therapeutic relevance of a DNA damage immune response (DDIR) signature in patients with advanced gastroesophageal adenocarcinoma

Subjects: gastroesophageal adenocarcinoma; DNA damage immune response; immune checkpoint inhibitors

  • Source: Baxter, M A, Spender, L C, Cairns, D, Walsh, S, Oparka, R, Porter, R J, Bray, S, Skinner, G, King, S, Turbitt, J, Collinson, D, Miedzybrodzka, Z H, Jellema, G, Logan, G, Kennedy, R D, Turkington, R C,

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Academic Journal

Zebrafish reveal new roles for Fam83f in hatching and the DNA damage-mediated autophagic response

Subjects: autophagy; development; DNA damage

  • Source: Jones, R A, Cooper, F, Kelly, G, Barry, D, Renshaw, M J, Sapkota, G & Smith, J C 2024, 'Zebrafish reveal new roles for Fam83f in hatching and the DNA

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Academic Journal

Chemo-phosphoproteomic profiling with ATR inhibitors berzosertib and gartisertib uncovers new biomarkers and DNA damage response regulators

Subjects: ATR; kinase; phosphoproteomic

  • Source: Jadav, R, Weiland, F, Noordermeer, S M, Carroll, T, Gao, Y, Wang, J, Zhou, H, Lamoliatte, F, Toth, R, Macartney, T, Brown, F, Hastie, J, Alabert, C, van Attikum, H, Zenke, F, Masson, J-Y & Rouse, J

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Academic Journal

HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS

Subjects: C9orf72; ALS; RNA toxicity

  • Source: Braems, E, Bercier, V, Van Schoor, E, Heeren, K, Beckers, J, Fumagalli, L, Dedeene, L, Moisse, M, Geudens, I, Hersmus, N, Mehta, A R, Selvaraj, B T, Chandran, S, Ho, R, Thal, D R, Van Damme, P,

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Academic Journal

Alterations in the p53 isoform ratio govern breast cancer cell fate in response to DNA damage

Subjects: Apoptosis; Breast cancer; DNA damage and repair

  • Source: Steffens Reinhardt, L, Zhang, X, Groen, K, Morten, B C, De Iuliis, G N, Braithwaite, A W, Bourdon, J-C & Avery-Kiejda, K A 2022, 'Alterations in the p53 isoform ratio govern breast cancer cell fate in

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Academic Journal

CDKL5 kinase controls transcription-coupled responses to DNA damage

Subjects: CDKL5 disorder; DNA damage response; kinase

  • Source: Khanam , T , Muñoz , I , Weiland , F , Carroll , T , Morgan , M , Borsos , B N , Pantazi , V , Slean , M , Novak , M , Toth , R , Appleton , P , Pankotai , T , Zhou , H & Rouse , J 2021 , ' CDKL5

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Academic Journal

Mutational signatures are jointly shaped by DNA damage and repair

Subjects: Cancer genomics; Computational models; DNA damage and repair

  • Source: Volkova, N V, Meier, B, González-Huici, V, Bertolini, S, Gonzalez, S, Vöhringer, H, Abascal, F, Martincorena, I, Campbell, P J, Gartner, A & Gerstung, M 2020, 'Mutational signatures are jointly

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Academic Journal

Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain

Subjects: DNA damage response; Proteolysis; Structural biology

  • Source: Magnussen , H M , Ahmed , S F , Sibbet , G J , Hristova , V A , Nomura , K , Hock , A K , Archibald , L J , Jamieson , A G , Fushman , D , Vousden , K H , Weissman , A M & Huang , D T 2020 , '

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Academic Journal

The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity

Subjects: APAF1; apoptosis; C. elegans

  • Source: Bailly , A P , Perrin , A , Serrano-Macia , M , Maghames , C , Leidecker , O , Trauchessec , H , Martinez-Chantar , M L , Gartner , A & Xirodimas , D P 2019 , ' The Balance between Mono- and

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