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Academic Journal

A missense mutation in the catalytic domain of O-GlcNAc transferase links perturbations in protein O-GlcNAcylation to X-linked intellectual disability

Subjects: O-GlcNAc; OGT; OGlcNAC transferase

  • Source: Pravata, V M, Gundogdu, M, Bartual, S G, Ferenbach, A T, Stavridis, M, Õunap, K, Pajusalu, S, Žordania, R, Wojcik, M H & van Aalten, D M F 2019, 'A missense mutation in the

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Academic Journal

Protein kinase C fusion proteins are paradoxically loss-of-function in cancer

Subjects: protein kinase C (PKC); gene fusions; cancer

  • Source: Van, A-A N, Kunkel, M T, Baffi, T R, Lordén, G, Antal, C E, Banerjee, S & Newton, A C 2021, 'Protein kinase C fusion proteins are paradoxically loss-of-function in cancer', Journal of Biological

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Academic Journal

Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA

Subjects: Amino Acid Substitution; Catalytic Domain; HEK293 Cells

  • Source: Gottschald Chiodi, C, Baptista-Hon, D, Hunter, W & Hales, T 2019, 'Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA', Journal of Biological Chemistry,

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Academic Journal

Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by ilimaquinone

Subjects: Journal Article; Mycobacterium tuberculosis shikimate kinase; Shikimate‑3‑phosphate

  • Source: Simithy, J, Fuanta, N R, Hobrath, J V, Kochanowska-Karamyan, A, Hamann, M T, Goodwin, D C & Calderón, A I 2018, 'Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by

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Academic Journal

The evolution of multiple active site configurations in a designed enzyme

Subjects: Catalytic Domain; Computer-Aided Design; Crystallography

  • Source: Hong, N-S, Petrović, D, Lee, R, Gryn'ova, G, Purg, M, Saunders, J, Bauer, P, Carr, P D, Lin, C-Y, Mabbitt, P D, Zhang, W, Altamore, T, Easton, C, Coote, M L, Kamerlin, S C L & Jackson, C J 2018, 'The

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Academic Journal

Inhibitors against Fungal Cell Wall Remodeling Enzymes

Subjects: Aspergillus fumigatus; carbohydrates; glycomimetics

  • Source: Delso, I, Valero-Gonzalez, J, Gomollón-Bel, F, Castro-López, J, Fang, W, Navratilova, I, van Aalten, D M F, Tejero, T, Merino, P & Hurtado-Guerrero, R 2018, 'Inhibitors against Fungal Cell Wall

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Academic Journal

High-resolution structure of the M14-type cytosolic carboxypeptidase from Burkholderia cenocepacia refined exploiting PDB_REDO strategies

Subjects: Amino Acid Sequence; Animals; Bacterial Proteins

  • Source: Rimsa, V, Eadsforth, T C, Joosten, R P & Hunter, W N 2014, 'High-resolution structure of the M14-type cytosolic carboxypeptidase from Burkholderia cenocepacia refined exploiting PDB_REDO strategies',

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Academic Journal

Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia :comparisons inform antimicrobial drug target assessment

Subjects: Amino Acid Sequence; Burkholderia cenocepacia; Catalytic Domain

  • Source: O'Rourke, P E F, Kalinowska-Tłuścik, J, Fyfe, P K, Dawson, A & Hunter, W N 2014, 'Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia : comparisons inform

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Academic Journal

Structure and reactivity of Trypanosoma brucei pteridine reductase:inhibition by the archetypal antifolate methotrexate

Subjects: Amino Acid Sequence; Animals; Binding Sites

  • Source: Dawson, A, Gibellini, F, Sienkiewicz, N, Tulloch, L B, Fyfe, P K, McLuskey, K, Fairlamb, A H & Hunter, W N 2006, 'Structure and reactivity of Trypanosoma brucei pteridine reductase : inhibition by the

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Academic Journal

Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability

Subjects: intellectual disability; O-GlcNAc; neurodevelopment

  • Source: Pravata, V, Muha, V, Gundogdu, M, Ferenbach, A, Kakade, P, Vandadi, V, Wilmes, A C, Borodkin, V, Joss, S, Stavridis, M & van Aalten, D 2019, 'Catalytic deficiency of

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