Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Epigenetics in the primary and secondary prevention of cardiovascular disease: influence of exercise and nutrition

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      University of Zurich; Groningen Institute for Organ Transplantation (GIOT); Cardiovascular Centre (CVC); Center for Liver, Digestive and Metabolic Diseases (CLDM); Reproductive Origins of Adult Health and Disease (ROAHD)
    • بيانات النشر:
      Oxford University Press, 2022.
    • الموضوع:
      2022
    • نبذة مختصرة :
      Increasing evidence links changes in epigenetic systems, such as DNA methylation, histone modification, and non-coding RNA expression, to the occurrence of cardiovascular disease (CVD). These epigenetic modifications can change genetic function under influence of exogenous stimuli and can be transferred to next generations, providing a potential mechanism for inheritance of behavioural intervention effects. The benefits of exercise and nutritional interventions in the primary and secondary prevention of CVD are well established, but the mechanisms are not completely understood. In this review, we describe the acute and chronic epigenetic effects of physical activity and dietary changes. We propose exercise and nutrition as potential triggers of epigenetic signals, promoting the reshaping of transcriptional programmes with effects on CVD phenotypes. Finally, we highlight recent developments in epigenetic therapeutics with implications for primary and secondary CVD prevention.
      European Journal of Preventive Cardiology, 29 (17)
      ISSN:2047-4873
      ISSN:2047-4881
    • File Description:
      application/pdf; ZORA_226364.pdf - application/pdf; application/application/pdf
    • ISSN:
      2047-4873
      2047-4881
    • Rights:
      OPEN
    • الرقم المعرف:
      edsair.doi.dedup.....1fbdcbda001df82f3d72503149c5aa13