Structure and Radioprotective Activity of Mercaptoacetyl Hydrazones of 6-Deoxy- and 2-(Acethylamino)aldoses

The condensation products of natural monosaccharides L-fucose, L-rhamnose, N-acetylamino-D-glucose and N-acetylamino-D-mannose with thioglycolic acid hydrazide have a cyclic 1,3,4-thiadiazine structure or are presented in solution in DMSO-d6 by a tautomeric mixture of pyranose and 1,3,4-thiadiazine forms. It was shown that L-rhamnose and N-acetylamino-D-mannose mercaptoacetyl hydrazones exhibit high radioprotective activity, increasing the survival rate of mortally irradiated mice by 35–45%.