Antisolvent Crystallization Method and Mixed Solvent Solubility Model Study of 2-Chloro-4,6-Dinitroresorcinol

Antisolvent crystallization method of 2-chloro-4,6-dinitroresorcinol was proposed and discussed for the first time. The yield of the product crystals was over 92.5%. Crystallization was carried out under the ambient temperature; ethanol was used as a solvent and water was used as an antisolvent. The technological conditions of antisolvent feed rate were studied, and 0.75 mL/min was the best operation. The solubility of 2-chloro-4,6-dinitroresorcinol in ethanol/water mixtures at 293.15–343.15 K was determined, and the Jouyban–Acree solubility equation was established. The mean deviation between experimental values and calculated ones was 1.81%.