The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic Syndrome and Related Cardiovascular Diseases.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, c1995-

Metabolic Syndrome*/drug therapy ; Cardiovascular Diseases*/drug therapy ; Cardiovascular Diseases*/etiology ; Oleanolic Acid*/pharmacology ; Oleanolic Acid*/therapeutic use ; Metabolic Diseases*; Humans ; Obesity

Metabolic syndromes (MetS) and related cardiovascular diseases (CVDs) pose a serious threat to human health. MetS are metabolic disorders characterized by obesity, dyslipidemia, and hypertension, which increase the risk of CVDs' initiation and development. Although there are many availabile drugs for treating MetS and related CVDs, some side effects also occur. Considering the low-level side effects, many natural products have been tried to treat MetS and CVDs. A five-cyclic triterpenoid natural product, oleanolic acid (OA), has been reported to have many pharmacologic actions such as anti-hypertension, anti-hyperlipidemia, and liver protection. OA has specific advantages in the treatment of MetS and CVDs. OA achieves therapeutic effects through a variety of pathways, attracting great interest and playing a vital role in the treatment of MetS and CVDs. Consequently, in this article, we aim to review the pharmacological actions and potential mechanisms of OA in treating MetS and related CVDs.

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No. 2022SK2011 Key Research and Development Projects of the Hunan Provincial Science and Technology Department; No. 2021RC4064 Science and Technology Innovation team of the Hunan Province; No. 20A379 Key Projects of the Hunan Provincial Department of Education; No. 2023CX163 Graduate Innovation Project of Hunan University of Chinese Medicine; No. 22B0387 Excellent Youth Project of the Hunan Provincial Department of Education; No. 2022JJ40314 Natural Science Foundation of the Hunan Province

Keywords: cardiovascular diseases; metabolic syndrome; oleanolic acid

6SMK8R7TGJ (Oleanolic Acid)

Date Created: 20240224 Date Completed: 20240226 Latest Revision: 20240227

20240227

PMC10892503

10.3390/molecules29040758

38398510