Conjunctiva in strabismus surgery - to stitch or to stick? - A randomized clinical trial.

Publisher: Medknow Publications Country of Publication: India NLM ID: 0405376 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1998-3689 (Electronic) Linking ISSN: 03014738 NLM ISO Abbreviation: Indian J Ophthalmol Subsets: MEDLINE

Publication: Mumbai : Medknow Publications
Original Publication: Bombay : All-India Ophthalmological Society

Tissue Adhesives*/therapeutic use ; Strabismus*/surgery ; Conjunctivitis* ; Pterygium*/surgery; Humans ; Fibrin Tissue Adhesive/pharmacology ; Fibrin Tissue Adhesive/therapeutic use ; Polyglactin 910 ; Prospective Studies ; Conjunctiva/surgery ; Suture Techniques ; Inflammation ; Sutures

Purpose: To evaluate the clinical outcomes with fibrin glue in comparison with vicryl sutures for limbal conjunctival wound closure in strabismus surgery.
Methods: In this prospective interventional study, patients undergoing horizontal muscle strabismus surgery were randomized into two groups: the vicryl suture group and the fibrin glue group. The limbal conjunctival incisions were closed with 8-0 vicryl in the suture group and with fibrin glue in the other group. The outcomes measured were post-operative conjunctival inflammation and wound apposition, patient comfort with the help of a questionnaire, and conjunctival thickness using anterior segment optical coherence tomography (AS-OCT) for both groups at 6 weeks.
Results: The study included 64 eyes of 64 patients (32 eyes in each group). The fibrin glue group performed better than the vicryl suture group for most of the symptoms like redness, irritation, watering, and foreign body sensation till 2 weeks post-operatively ( P < 0.001), after which both the groups performed similarly. As for clinical signs, no significant difference was noted between the two groups, except for conjunctival hyperemia, which was significantly lesser in the fibrin glue group at 2 weeks post-operatively ( P < 0.001). The conjunctival thickness measured at 6 weeks using AS-OCT revealed that the thickness increased significantly in the suture group compared to that in the glue group ( P < 0.001 medial site, P = 0.004 lateral site).
Conclusion: Because of greater patient comfort and reduced inflammation associated with fibrin glue, it may be considered as a procedure of choice for conjunctival wound closure in strabismus surgery in the absence of the cost constraints.
(Copyright © 2023 Copyright: © 2023 Indian Journal of Ophthalmology.)

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0 (Fibrin Tissue Adhesive)
0 (Tissue Adhesives)
34346-01-5 (Polyglactin 910)

Date Created: 20231215 Date Completed: 20240129 Latest Revision: 20240317

20240317

PMC10941947

10.4103/IJO.IJO_543_23

38099382