Item request has been placed!
×
Item request cannot be made.
×
Processing Request
Thiamine responsive high output heart failure of adults: an under-recognized entity
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- المؤلفون: Nisar, Sobia; Mohi-u-din, Khalid; Tak, Shahid Iqbal; Andrabi, Syed Manzoor Ali; Tanvir, Masood; Muzaffer, Umar; Kareem, Ozaifa; Ganie, Mohd. Ashraf
- المصدر:
European Journal of Clinical Nutrition; July 2023, Vol. 77 Issue: 7 p757-760, 4p
- معلومة اضافية
- نبذة مختصرة :
Thiamine deficiency, commonly presenting as dry and wet beriberi, a lesser-known entity in the present era, is increasingly being reported from Kashmir, a north Indian state. The present study aims to present the clinical profile of patients presenting with high-output heart failure (HOHF). Subjects with a primary diagnosis of denovo heart failure and features suggestive of HOHF were recruited; those who responded to intravenous administration of thiamine alone (responders) were adults with no co-morbidities and those who required other medications particularly diuretics (non-responders) were elderly with co-morbidities and underlying heart disease. Responders showed considerably lower mean thiamine pyrophosphate (TPP) levels and higher mean lactate and venous oxygen saturation than non-responders. More importantly, the mean drop in lactate and SVO2 following thiamine therapy was more in responders. In a setting of high risk for thiamine deficiency, features suggestive of HOHF along with elevated lactate and higher venous oxygen saturation, a response to thiamine challenge may serve as surrogate marker of thiamine deficiency.
No Comments.