Nomograms predicting overall survival and cancer-specific survival for patients with appendiceal cancer after surgery

In order to establish nomograms that could forecast the postoperative survival for patients with appendiceal cancer after surgery, this study collected 5945 patients with surgically removed appendiceal cancer from the Surveillance, Epidemiology, and End Results database. Overall survival (OS) and cancer-specific survival (CSS) were analyzed by Cox regression analysis and nomograms. The population was randomly separated into a training group (n= 3963) and a validation group (n= 1982). Age, histological grade, T stage, N stage, regional nodes examination, tumor size, and CEA were independent prognostic factors for OS and were used in the nomogram. In addition, radiotherapy and chemotherapy were independent prognostic factors for CSS. The C-index values of the nomograms predicting postoperative OS and CSS were 0.76 (95% CI 0.74–0.78) and 0.80 (95% CI 0.78–0.82) in the training group and 0.77 (95% CI 0.74–0.79) and 0.81 (95% CI 0.78–0.84) in the validation group. Moreover, nomograms were better than traditional American Joint Committee on Cancer (AJCC) TNM 8th Edition Staging System in predicting prognosis derived from the results of DCA and ROC curves. In a word, we constructed new nomograms based on a large database that can accurately predict the OS and CSS of patients with appendiceal cancer after surgery.