نبذة مختصرة : Objectives: Previous studies have described impaired platelet function after cardiopulmonary bypass (CPB). Whether this is still valid in con-temporary cardiac surgery is unclear. This study aimed to quantify changes in function and number of platelets during CPB in a present-day car-diac surgery cohort. Design: Prospective, controlled clinical study. Setting: A single-center university hospital. Participants: Thirty-nine patients scheduled for coronary artery bypass graft surgery with CPB. Interventions: Platelet function and numbers were measured at 6 timepoints in 39 patients during and after coronary artery bypass graft surgery; at baseline before anesthesia, at the end of CPB, after protamine administration, at intensive care unit (ICU) arrival, 3 hours after ICU arrival, and on the morning after surgery. Measurements and Main Results: Platelet function was assessed with impedance aggregometry and flow cytometry. Platelet numbers are expressed as actual concentration and as numbers corrected for dilution using hemoglobin as a reference marker. There was no consistent impairment of platelet function during CPB with either impedance aggregometry or flow cytometry. After protamine administration, a decrease in platelet function was seen with impedance aggregometry and for some markers of activation with flow cytometry. Platelet function was restored 3 hours after arrival in the ICU. During CPB (85.0 & PLUSMN; 21 min), the number of circulating platelets corrected for dilution increased from 1.73 & PLUSMN; 0.42 & POUND; 109/g to 1.91 & PLUSMN; 0.51 & POUND; 109/g (p < 0.001). Conclusions: During cardiac surgery with moderate CPB times, platelet function was not impaired, and no consumption of circulating platelets could be detected. Administration of protamine transiently affected platelet function. & COPY; 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
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