- Patent Number:
11958,836
- Appl. No:
16/977209
- Application Filed:
March 19, 2019
- نبذة مختصرة :
The present invention relates to a novel micronized 1,4-di(benzoxazol-2′-yl)benzene as well as to the use thereof in topical compositions.
- Inventors:
DSM IP ASSETS B.V. (Heerlen, NL)
- Assignees:
DSM IP ASSETS B.V. (Heerlen, NL)
- Claim:
1. A micronized solid amorphous 1,4-di(benzoxazol-2′-yl)benzene of formula (I), [chemical expression included] wherein the micronized 1,4-di(benzoxazol-2′-yl)benzene has a mean particle size Dn50 of 50 nm to 300 nm as determined by laser diffraction, and wherein the 1,4-di(benzoxazol-2′-yl)benzene has a ratio UVB:UVA in a range of 0.40 to 0.55 and a specific absorbance E 1/1 @ 320 nm of ≥780.
- Claim:
2. The micronized solid amorphous 1,4-di(benzoxazol-2′-yl)benzene according to claim 1 , wherein the mean particle size is in a range from 120 to 280 nm.
- Claim:
3. The micronized solid amorphous 1,4-di(benzoxazol-2′-yl)benzene according to claim 1 , wherein the ratio UVB:UVA of the micronized solid amorphous 1,4-di(benzoxazol-2′-yl)benzene is in a range of 0.44 to 0.54.
- Claim:
4. The micronized solid amorphous 1,4-di(benzoxazol-2′-yl)benzene according to claim 1 , wherein the mean particle size is in a range of 150 to 220 nm.
- Claim:
5. The micronized solid amorphous 1,4-di(benzoxazol-2′-yl)benzene according to claim 1 , wherein the ratio UVB:UVA of the solid amorphous micronized 1,4-di(benzoxazol-2′-yl)benzene is in a range of 0.47 to 0.51.
- Claim:
6. An aqueous dispersion comprising the micronized solid amorphous 1,4-di(benzoxazol-2′-yl)benzene according to claim 1 .
- Claim:
7. The aqueous dispersion according to claim 6 , wherein the micronized solid amorphous 1,4-di(benzoxazol-2′-yl)benzene is present in the aqueous dispersion in an amount of 25 to 60 wt.-%, based on the total weight of the aqueous dispersion.
- Claim:
8. The aqueous dispersion according to claim 7 , wherein the amount of the micronized solid amorphous 1,4-di(benzoxazol-2′-yl)benzene in the aqueous dispersion is in a range from 25 to 55 wt.-%, based on the total weight of the aqueous dispersion.
- Claim:
9. The aqueous dispersion according to claim 6 , wherein the aqueous dispersion further comprises at least one grinding aid and/or at least one additive.
- Claim:
10. The aqueous dispersion according to claim 9 , wherein the at least one grinding aid is an alkyl poly-glucoside and the at least one additive is selected from the group consisting of wetting agents, thickeners, anti-foam agents and mixtures thereof.
- Claim:
11. The aqueous dispersion according to claim 9 , wherein the at least one additive is selected from the group consisting of propyleneglycol, xanthan gum, gellan gum, simethicone and mixtures thereof.
- Claim:
12. A topical composition comprising the aqueous dispersion according to claim 6 .
- Claim:
13. A topical composition comprising the micronized solid amorphous 1,4-di(benzoxazol-2′-yl)benzene thereof according to claim 1 .
- Claim:
14. The topical composition according to claim 13 , wherein micronized solid amorphous 1,4 di(benzoxazol-2′-yl)benzene is present in the topical composition in an amount in a range from 0.1 to 20 wt. %, based on the total weight of the topical composition.
- Claim:
15. The topical composition according to claim 13 , wherein micronized solid amorphous 1,4 di(benzoxazol-2′-yl)benzene is present in the topical composition in an amount in a range from 0.5 to 15 wt. %, based on the total weight of the topical composition.
- Claim:
16. The topical composition according to claim 13 , wherein micronized solid amorphous 1,4 di(benzoxazol-2′-yl)benzene is present in the topical composition in an amount in a range from 1 to 10 wt. %, based on the total weight of the topical composition.
- Claim:
17. The topical composition according to claim 13 , wherein the topical composition is in the form of an oil-in-water (O/W) emulsion or in the form of a water-in-oil (W/O) emulsion.
- Claim:
18. A method of preparing the micronized solid amorphous 1,4-di(benzoxazol-2′-yl)benzene according to claim 1 , wherein the method comprises the steps of (a) preparing a mixture of coarse solid amorphous particles of the 1,4-di(benzoxazol-2′-yl)benzene of the formula (I), water and milling bodies and optionally at least one grinding aid and/ or optionally at least one further additive, and (b) grinding the mixture of step (a) until the coarse solid amorphous particles of the 1,4-di(benzoxazol-2′-yl)benzene achieve a mean particle size Dn50 of 50 nm to 300 nm.
- Claim:
19. A method of reducing transfer of fat and oil components of a topical composition to a surface, the method comprising the step of incorporating into a topical composition containing the fat and oil components an amount of the solid amorphous micronized 1,4-di(benzoxazol-2′-yl)benzene according to claim 1 which is effective to reduce transfer of the fat and oil components to a surface.
- Patent References Cited:
6030607 February 2000 Linares
1 317 918 June 2003
02/39972 May 2002
2002/039972 May 2002
- Other References:
International Search Report for PCT/EP2019/056881, dated May 2, 2019, 3 pages. cited by applicant
Written Opinion of the ISA for PCT/EP2019/056881, dated May 2, 2019, 7 pages. cited by applicant
Baeg et al, “Effective UVA and UVB protection from TiO2 UV filter,” Aston Chemicals, Personal Care, pp. 51-56, UK, Nov. 2012. cited by applicant
Herzog et al, “Physical properties of organic particulate UV absorbers used in sunscreens,” Journal of Colloid and Interface Science 276 (2004) 354-363. cited by applicant
- Primary Examiner:
Seaman, D Margaret M
- Attorney, Agent or Firm:
NIXON & VANDERHYE P.C.
- الرقم المعرف:
edspgr.11958836
Processing Request
No Comments.