- Patent Number:
11358,873
- Appl. No:
16/261790
- Application Filed:
January 30, 2019
- نبذة مختصرة :
One object of the present invention is to provide a method for producing stable isotope labeled carbon monoxide capable of controlling the abundance ratio of a specific kind of the stable oxygen isotope to be an arbitrary value, the present invention provides a method for producing stable isotope labeled carbon monoxide including: a first mixing step in which carbon monoxide selectively containing at least one kind of stable isotope selected from the group consisting of 12C16O, 12C17O, 12C18O, 13C16O, 13C17O, and 13C18O, and water vapor selectively containing at least one kind of stable isotope selected form the group consisting of H216O, H217O and H218O are mixed to produce stable isotope labeled carbon dioxide: and a second mixing step in which the stable isotope labeled carbon dioxide produced in the first mixing step and hydrogen are mixed.
- Inventors:
TAIYO NIPPON SANSO CORPORATION (Tokyo, JP)
- Assignees:
TAIYO NIPPON SANSO CORPORATION (Tokyo, JP)
- Claim:
1. A method for producing stable isotope labeled carbon monoxide comprising: a first mixing step in which carbon monoxide selectively containing at least one kind of stable isotope selected from the group consisting of 12 C 16 O, 12 C 17 O, 12 C 18 O, 13 C 16 O, 13 C 17 O, and 13 C 18 O, and water vapor selectively containing at least one kind of stable isotope selected from the group consisting of H 2 16 O, H 2 17 O and H 2 18 O are mixed to produce stable isotope labeled carbon dioxide; and a second mixing step in which the stable isotope labeled carbon dioxide produced in the first mixing step and hydrogen are mixed, wherein step said carbon monoxide contains at least 13 C 18 O and said water vapor contains at least one of H 2 16 O and H 2 17 O so that carbon monoxide containing 13 C 18 O and water vapor containing either or both of H 2 16 O and H 2 17 O are mixed.
- Claim:
2. The method for producing stable isotope labeled carbon monoxide according to claim 1 , wherein, in the first mixing step, a volume ratio (V 1 /V 2) between a flow rate V 1 of the water vapor and a flow rate V 2 of the carbon monoxide is set to 1 to 100.
- Claim:
3. The method for producing stable isotope labeled carbon monoxide according to claim 1 , wherein, in the second mixing step, a volume ratio (V 3 /V 4) between a flow rate V 3 of the hydrogen and a flow rate V 4 of the stable isotope labeled carbon dioxide is set to 1 to 20.
- Claim:
4. The method for producing stable isotope labeled carbon monoxide according to claim 1 , wherein, before the first mixing step, an abundance ratio of stable carbon isotope in the carbon monoxide is controlled to be an arbitrary value in advance.
- Claim:
5. The method for producing stable isotope labeled carbon monoxide according to claim 1 , wherein, before the first mixing step, an abundance ratio of stable oxygen isotope in the water vapor is controlled to be an arbitrary value in advance.
- Claim:
6. The method for producing stable isotope labeled carbon monoxide according to claim 1 , wherein, after the second mixing step, an abundance ratio of stable carbon isotope is controlled to be an arbitrary value.
- Claim:
7. The method for producing stable isotope labeled carbon monoxide according to claim 1 , wherein the second mixing step is performed a plurality of times.
- Claim:
8. The method for producing stable isotope labeled carbon monoxide according to claim 1 , wherein the at least one kind of stable oxygen isotope in the stable isotope selectively contained in the carbon monoxide and a kind of stable oxygen isotope in the stable isotope selectively contained in the water vapor are different from each other.
- Claim:
9. A method for producing stable isotope labeled carbon monoxide comprising: a first mixing step in which carbon monoxide selectively containing at least one kind of stable isotope selected from the group consisting of 12 C 16 O, 12 C 17 O, 12 C 18 O, 13 C 16 O, 13 C 17 O, and 13 C 18 O, and water vapor selectively containing at least one kind of stable isotope selected form the group consisting of H 2 16 O, H 2 17 O and H 2 18 O are mixed to produce stable isotope labeled carbon dioxide: and a second mixing step in which the stable isotope labeled carbon dioxide produced in the first mixing step and hydrogen are mixed, wherein the carbon monoxide includes 1 to 20 atom % of stable isotope having 18 O with respect to the total of 100 atom % of stable isotope labeled carbon monoxide having 16 O, stable isotope labeled carbon monoxide having 17 O, and stable isotope labeled carbon monoxide having 18 O.
- Claim:
10. The method for producing stable isotope labeled carbon monoxide according to claim 9 , wherein, in the first mixing step, a volume ratio (V 1 /V 2) between a flow rate V 1 of the water vapor and a flow rate V 2 of the carbon monoxide is set to 1 to 100.
- Claim:
11. The method for producing stable isotope labeled carbon monoxide according to claim 9 , wherein, in the second mixing step, a volume ratio (V 3 /V 4) between a flow rate V 3 of the hydrogen and a flow rate V 4 of the stable isotope labeled carbon dioxide is set to 1 to 20.
- Claim:
12. The method for producing stable isotope labeled carbon monoxide according to claim 6 , wherein, before the first mixing step, an abundance ratio of stable carbon isotope in the carbon monoxide is controlled to be an arbitrary value in advance.
- Claim:
13. The method for producing stable isotope labeled carbon monoxide according to claim 9 , wherein, before the first mixing step, an abundance ratio of stable oxygen isotope in the water vapor is controlled to be an arbitrary value in advance.
- Claim:
14. The method for producing stable isotope labeled carbon monoxide according to claim 9 , wherein, after the second mixing step, an abundance ratio of stable carbon isotope is controlled to be an arbitrary value.
- Claim:
15. The method for producing stable isotope labeled carbon monoxide according to claim 9 , wherein the second mixing step is performed a plurality of times.
- Claim:
16. The method for producing stable isotope labeled carbon monoxide according to claim 9 , wherein the water vapor contains 95 atom % or more of H 2 18 O with respect to a total of 100 atom % of H 2 16 O, H 2 17 O, and H 2 18 O.
- Claim:
17. The method for producing stable isotope labeled carbon monoxide according to claim 9 , wherein the at least one kind of stable oxygen isotope in the stable isotope selectively contained in the carbon monoxide and a kind of stable oxygen isotope in the stable isotope selectively contained in the water vapor are different from each other.
- Claim:
18. The method for producing stable isotope labeled carbon monoxide according to claim 9 , wherein the water vapor selectively contains one or both of H 2 16 O and H 2 17 O.
- Patent References Cited:
6321565 November 2001 Kihara
6461583 October 2002 Hayashida
2009/0158663 June 2009 Deluga
105126835 December 2015
3-060722 March 1991
2010-58043 March 2010
- Other References:
Andreev, “Separation of Isotopes of Biogenic Elements in Two-phase Systems”, First Edition, ISBN:9780444529817, Elsevier, Science, Dec. 28, 2006, pp. 217-245. cited by applicant
Office Action issued in JP Appln. No. 2018-020361 dated Apr. 6, 2021 (w/ translation). cited by applicant
- Primary Examiner:
Wartalowicz, Paul A
- Attorney, Agent or Firm:
Nixon & Vanderhye P.C.
- الرقم المعرف:
edspgr.11358873
Processing Request
No Comments.