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Method of preventing myocardial reperfusion injury in reperfusion therapy by administering intravenous immunoglobulin

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اقرأ أكثر حفظ في قائمتي
  • Publication Date:
    October 02, 2018
  • معلومة اضافية
    • Patent Number:
      10087,238
    • Appl. No:
      15/439807
    • Application Filed:
      February 22, 2017
    • نبذة مختصرة :
      The method of preventing reperfusion injury in reperfusion therapy is a medical technique for prevention of reperfusion injury in a patient where reperfusion therapy is necessary, such as following myocardial infarction (MI) or heat transplant in the patient. The patient is treated with intravenous immunoglobulin (IVIG) prior to an ischemic event or, alternatively, following the ischemic event, with the intravenous immunoglobulin providing cardio-protective effects to the patient for preventing reperfusion injury. The treatment with the IVIG may be used with any suitable type of reperfusion therapy, such as thrombolytic therapy, coronary angioplasty or coronary artery bypass surgery.
    • Inventors:
      KUWAIT UNIVERSITY (Safat, KW)
    • Assignees:
      KUWAIT UNIVERSITY (Safat, KW)
    • Claim:
      1. A method of alleviating reperfusion injury in reperfusion therapy, comprising the steps of: performing regional myocardial ischemia reperfusion on a patient; and treating the patient with an effective amount of intravenous immunoglobulin after an ischemic event, wherein the intravenous immunoglobulin has a cardio-protective effect to alleviate reperfusion injury in the patient, wherein the effective amount of the intravenous immunoglobulin comprises treating the patient with from 0.6 g to 1.0 g of the intravenous immunoglobulin per kilogram of body weight of the patient.
    • Claim:
      2. The method of preventing reperfusion injury in reperfusion therapy as recited in claim 1 , wherein the step of performing regional myocardial ischemia reperfusion on the patient comprises performing thrombolytic therapy on the patient.
    • Claim:
      3. The method of preventing reperfusion injury in reperfusion therapy as recited in claim 1 , wherein the step of performing regional myocardial ischemia reperfusion on the patient comprises performing coronary angioplasty on the patient.
    • Claim:
      4. The method of preventing reperfusion injury in reperfusion therapy as recited in claim 1 , wherein the step of performing regional myocardial ischemia reperfusion on the patient comprises performing coronary artery bypass surgery on the patient.
    • Claim:
      5. The method of preventing reperfusion injury in reperfusion therapy as recited in claim 1 , wherein the step of performing regional myocardial ischemia reperfusion on the patient comprises performing post-heart transplantation reperfusion on the patient.
    • Patent References Cited:
      2003/0170241 September 2003 Aukrust et al.
      2013/0273052 October 2013 Gies et al.
      WO 01/66124 September 2001


    • Other References:
      Ueno et al (2007. Circulation. 116:II_99). cited by examiner
      Ueno, “Effect of intravenous administration of polyclonal immunoglobulin G on myocardial ischemia reperfusion injury”, Fiscal 2009 results report, available at https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790547/207905472009jisseki/, 1 page as printed; English translation attached. cited by examiner
      Araszkiewicz et al, 2013. Postep Kardiol Inter, 9, 3(33): 275-281. cited by examiner
    • Primary Examiner:
      Howard, Zachary C
    • Attorney, Agent or Firm:
      Litman, Richard C.
    • الرقم المعرف:
      edspgr.10087238