- Patent Number:
7,740,888
- Appl. No:
12/100578
- Application Filed:
April 10, 2008
- نبذة مختصرة :
An extract of passion fruit is prepared. The extract has the effect of lowering blood pressure and serum nitric oxide levels in mammals. The extract also provides a hepatoprotective effect, as well as antioxidant and anti-inflammatory effects in mammals. A novel compound was identified in the extract and given the name edulilic acid.
- Inventors:
Foo, Lai Yeap (Lower Hutt, NZ); Lu, Yinrong (Lower Hutt, NZ); Watson, Ronald Ross (Tucson, AZ, US)
- Assignees:
Industrial Research Limited (Parnell, Auckland, NZ), Southwest Scientific Editing & Consulting LLC (Tucson, AZ, US)
- Claim:
1. An extract of passion fruit containing edulilic acid prepared by a method comprising the steps of: (a) contacting passion fruit skin with water to provide an aqueous extract and a solid residue; (b) passing the aqueous extract through a column of non-ionic polymeric resin to adsorb phenolic compounds, including at least edulilic acid, from the aqueous extract; (c) removing sugars and other polar compounds from the column by passing an aqueous solution through the column; (d) eluting the phenolic compounds from the resin using an organic solvent; and (e) drying the eluent to produce a product having greater than 1% edulic acid by weight.
- Claim:
2. An extract of passion fruit as defined in claim 1 , wherein the edulilic acid has the structure: [chemical expression included] and/or the cis isomer thereof.
- Claim:
3. An extract according to claim 1 , wherein the organic solvent is selected from the group consisting of methanol, ethanol, isopropyl alcohol, 1-propanol, acetone, and combinations thereof.
- Current U.S. Class:
424/777
- Patent References Cited:
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- Other References:
Kidoy et al. J. Food Composition and Analysis. 1997. vol. 10, pp. 49-54. cited by examiner
Chassagne et al. J. Agric. Food Chem. 1996. vol. 44, No. 12, pp. 3817-3820. cited by examiner
Mohamed et al. Pertanika J. Trop. Agric. Sci. 1994. vol. 17, No. 3, pp. 219-227. cited by examiner
Pruthi et al. J. Food Sci. 1961. vol. 26, pp. 385-388. cited by examiner
Kidoy, Linda et al.: “Anthocyanins in fruits of Passiflora edulis and P. suberosa” Journal of Food Composition and Analysis, vol. 10, No. 1 1997, pp. 49-54, XP--2535196. cited by other
S. Zibadi: “Passion fruit (Passiflora edulis). Composition, efficay and safety” Evid Base Integrative Med, vol. 1, No. 3, 2004, pp. 183-187, SP002535204. cited by other
Dhawan Kamaldeep et al.: “Passiflora: a review update” Journal of Ethnopharmacology, vol. 94, No. 1, Sep. 2004, pp. 1-23, SP002535205. cited by other
Mohamed, et al.: Antimicrobial activity of some tropical fruit wastes (guava, starfruit, banana, papaya, passionfruit, langsat, duku, rambutan and rambai). Pertanika Jouranl of Tropical Agricultural Science. 1994, vol. 17, No. 3, pp. 219-227. cited by other
Chevallier, A. DK: Natural Health. In: Encyclopedia of Herbal Medicine. 2000, 2nd Ed., pp. 290-391. Dorling Kindersley Limited (London). cited by other
- Primary Examiner:
Tate, Christopher R.
- Attorney, Agent or Firm:
Herink, Kent A.
Harris, Emily E.
- الرقم المعرف:
edspgr.07740888
Processing Request
No Comments.