PUMP CONTROLLER AND CONTROL METHOD WITH TEMPERATURE INTEGRATION AND/OR COMPLIANCE DETERMINATION

20240335609

18/427333

January 30, 2024

A method includes calculating a volume of fluid in a pumping chamber when the chamber is not full or empty based on pressure and temperature measurements taken during a negative full-volume state, a positive full-volume state, and an empty-volume state, and an infusion system includes a controller configured to carry out such calculation. Such method, or a separate method, may measure temperature and pressure of a common volume and a pumping chamber, wherein the pressure is measured using a pressure sensor and the temperature is measured using a temperature sensor, optionally one that measures the temperature of the pressure sensor, and calculate a volume of fluid in the pumping chamber based on ideal gas law and the pressure and temperature measurements, and such infusion system, or a separate system, includes a controller configured to carry out such measurement and calculation.

1. A method comprising: applying a negative gauge pressure from a common volume to a diaphragm in a pumping chamber to fill the pumping chamber with a fluid from a fluid source; applying the negative gauge pressure to the diaphragm with the pumping chamber filled with the fluid to define a negative full-volume state, and measuring temperature and pressure of the common volume and the pumping chamber during the negative full-volume state; applying a positive gauge pressure to the diaphragm with the pumping chamber filled with the fluid to define a positive full-volume state, and measuring the temperature and pressure of the common volume and the pumping chamber during the positive full-volume state; applying the positive gauge pressure to the diaphragm with the pumping chamber empty to define an empty-volume state, and measuring the temperature and pressure of the common volume and the pumping chamber during the empty-volume state; and calculating a volume of fluid in the pumping chamber when the chamber is not full or empty based on the pressure and temperature measurements taken during the negative full-volume state, the positive full-volume state, and the empty-volume state.

2. The method according to claim 1, further comprising calculating a pump side pumping chamber volume based on the pressure and temperature measurements taken during the negative full-volume state.

3. The method according to claim 2, further comprising: calculating a total volume of air in the pumping chamber on air side and fluid side based on the pressure and temperature measurements taken during the positive full volume state; and calculating a difference between the pump side pumping chamber volume and the total volume of air in the pumping chamber to calculate a volume of air on the fluid side of the pumping chamber.

4. The method according to claim 2, further comprising: calculating a total pumping chamber volume based on the pressure and temperature measurements taken during the empty volume state; and calculating a stroke volume according to the difference between the total pumping chamber volume and the pump side pumping chamber volume.

5. The method according to claim 1, wherein the temperature measurements are based on an average of temperature measurements from a plurality of temperature sensors and an ambient temperature.

6. The method according to claim 5, wherein the plurality of temperature sensors are associated with the common volume and the pumping chamber, and a positive pressure tank and a negative pressure tank coupled to the common volume.

7. The method according to claim 5, wherein: the temperature measurements are calculated as mass-weighted average temperatures, and a pumping chamber temperature is based on a constant volume region within the pumping chamber at the average of temperature measurements of the plurality of temperature sensors and a remaining volume region of an air side of the pumping chamber at an administrative set temperature that is based on the average of the temperature measurements of the plurality of temperature sensors and the ambient temperature; and the administrative set temperature is calculated according to: [mathematical expression included] where TS is the administrative set temperature; TA is the ambient temperature; β is a parameter that accounts for pre-heating of the set side pumping chamber volume by pump side pumping chamber air; and TM is the average of temperature measurements of the plurality of temperature sensors.

8. The method according to claim 5, wherein the average of temperature measurements of the plurality of temperature sensors is taken of temperature measurements of a subset of the plurality of temperature sensors.

9. The method according to claim 5, wherein each of the plurality of temperature sensors comprise a temperature sensor associated with a pressure sensor.

10. The method according to claim 1, further comprising: isolating the filled pumping chamber from the fluid source and a recipient before applying the negative gauge pressure to the diaphragm with the pumping chamber filled with the fluid, and before applying the positive gauge pressure to the diaphragm with the pumping chamber filled with the fluid, wherein an inlet valve is disposed between the pumping chamber and the fluid source, an outlet valve is disposed between the pumping chamber and the recipient, and isolating the pumping chamber comprises closing the inlet valve and the outlet valve.

11. An infusion system comprising: a common volume; a pumping chamber comprising a diaphragm, a fluid inlet coupled to a fluid source, and a fluid outlet, the pumping chamber coupled to the common volume; a pressure sensor and a temperature sensor associated with each of the common volume and the pumping chamber; a controller coupled to the pressure sensors and temperature sensors, the controller configured to: apply a negative gauge pressure from the common volume to the diaphragm in the pumping chamber to fill the pumping chamber with a fluid from the fluid source; apply the negative gauge pressure to the diaphragm with the pumping chamber filled with the fluid to define a negative full-volume state, and measure temperature and pressure of the common volume and the pumping chamber during the negative full-volume state; apply a positive gauge pressure to the diaphragm with the pumping chamber filled with the fluid to define a positive full-volume state, and measure the temperature and pressure of the common volume and the pumping chamber during the positive full-volume state; apply the positive gauge pressure to the diaphragm with the pumping chamber empty to define an empty-volume state, and measure the temperature and pressure of the common volume and the pumping chamber during the empty-volume state; and calculate a volume of fluid in the pumping chamber when the chamber is not full or empty based on the pressure and temperature measurements taken during the negative full-volume state, the positive full-volume state, and the empty-volume state.

12. The system according to claim 11, wherein the controller is configured to calculate a pump side pumping chamber volume based on the pressure and temperature measurements taken during the negative full-volume state.

13. The system according to claim 12, wherein the controller is configured to calculate a total amount of air in the pumping chamber on air side and fluid side based on the pressure and temperature measurements taken during the positive full volume state, and to calculate a difference between the pump side pumping chamber volume and the total volume of air in the pumping chamber to calculate a volume of air on the fluid side of the pumping chamber.

14. The system according to claim 12, wherein the controller is configured to calculate a total pumping chamber volume based on the pressure and temperature measurements taken during the empty volume state, and to calculate a stroke volume according to the difference between the total pumping chamber volume and the pump side pumping chamber volume.

15. The system according to claim 11, wherein the temperature measurements are based on an average of temperature measurements from a plurality of temperature sensors and an ambient temperature.

16. The system according to claim 15, wherein the plurality of temperature sensors are associated with the common volume, the pumping chamber, and a positive pressure tank and a negative pressure tank coupled to the common volume.

17. The system according to claim 15, wherein the controller is configured: to calculate the temperature measurements as mass-weighted average temperatures, and a pumping chamber temperature is based on a constant volume region within the pumping chamber at the average of temperature measurements of the plurality of temperature sensors and a remaining volume region of an air side of the pumping chamber at an administrative set temperature that is based on the average of the temperature measurements of the plurality of temperature sensors and the ambient temperature; and to calculate the administrative set temperature according to: [mathematical expression included] where TS is the administrative set temperature; TA is the ambient temperature; β is a parameter that accounts for pre-heating of the set side pumping chamber volume by pump side pumping chamber air; and TM is the average of temperature measurements of the plurality of temperature sensors.

18. The system according to claim 15, wherein the average of temperature measurements of the plurality of temperature sensors is taken of temperature measurements of a subset of the plurality of temperature sensors.

19. The system according to claim 15, wherein each of the plurality of temperature sensors comprise a temperature sensor associated with a pressure sensor.

20. The system according to claim 11, further comprising an inlet valve disposed between the pumping chamber and the fluid source and an outlet valve disposed between the pumping chamber and the recipient, wherein the controller is configured to isolate the filled pumping chamber from the fluid source and a recipient before applying the negative gauge pressure to the diaphragm with the pumping chamber filled with the fluid, and before applying the positive gauge pressure to the diaphragm with the pumping chamber filled with the fluid, and wherein the controller is configured to isolate the pumping chamber by closing the inlet valve and the outlet valve.

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