- Document Number:
20240263233
- Appl. No:
18/427553
- Application Filed:
January 30, 2024
- نبذة مختصرة :
Systems for processing a cellular sample are provided. Embodiments of the systems include a tray configured to receive a multi-microwell-array-flowcell cartridge, and a retrieval magnet assembly configured to apply a uniform magnetic force to flowcells of the cartridge when in an active position. Also provided are methods, which methods may include introducing a multi-microwell-array-flowcell cartridge into the system of the invention, loading a sample into the multi-microwell-array-flowcell cartridge, actuating the retrieval magnet assembly to the active position and applying the uniform magnetic force to the sample within the multi-microwell-array-flowcell cartridge to produce a processed sample, and collecting the processed sample from the multi-microwell-array-flowcell cartridge. In addition, multi-microwell-array-flowcell cartridges are disclosed. Embodiments of the subject cartridges include a plurality of fluidic lanes, each fluidic lane comprising, an inlet for receiving liquid, a flow cell comprising a microwell array, and an outlet for discharging liquid.
- Claim:
1. A system comprising: a tray configured to receive a multi-microwell-array-flowcell cartridge; and a retrieval magnet assembly configured to apply a uniform magnetic force to flowcells of the cartridge when in an active position.
- Claim:
2. The system according to claim 1, wherein the retrieval magnet assembly is configured to apply the uniform magnetic force from a position that is superior to the tray.
- Claim:
3. (canceled)
- Claim:
4. The system according to claim 1, wherein the retrieval magnet assembly is configured to apply the uniform magnetic force via a plurality of magnets.
- Claim:
5. The system according to claim 4, wherein magnets of plurality have alternating polarities.
- Claim:
6-13. (canceled)
- Claim:
14. The system according to claim 1, wherein the retrieval magnet assembly is actuatable between the active position in which the retrieval magnet assembly is positioned adjacent to the tray, and an inactive position in which the retrieval magnet is located at a further distance from the tray relative to the active position.
- Claim:
15. The system according to claim 1, further comprising a sample collection vessel holder configured to receive a plurality of sample collection vessels for collecting an analyte from the cartridge.
- Claim:
16. The system according to claim 15, further comprising the plurality sample collection vessels.
- Claim:
17. (canceled)
- Claim:
18. The system according to claim 16, wherein the system comprises a number of sample collection vessels that matches the number of flowcells in the cartridge.
- Claim:
19. (canceled)
- Claim:
20. The system according to claim 15, wherein the sample collection vessel holder comprises a counterweight configured to maintain the sample collection holder in an upright position.
- Claim:
21. The system according to claim 1, wherein system and the sample collection vessel holder have complementary shapes such that the sample collection vessel holder may be received in the system in a single orientation.
- Claim:
22. The system according to claim 1, further comprising a drawer that is moveable between a plurality of different positions within the system.
- Claim:
23. The system according to claim 1, further comprising a waste collection vessel for collecting liquid waste from the multi-microwell-array-flowcell cartridge.
- Claim:
24. The system according to claim 23, wherein the system comprises a single waste collection vessel.
- Claim:
25. The system according to claim 23, further comprising an interlock configured to prevent the collection of sample liquid into the waste collection vessel when the retrieval magnet assembly is in the active position.
- Claim:
26. The system according to claim 1, wherein the tray comprises a latch for retaining the multi-microwell-array-flowcell cartridge.
- Claim:
27. The system according to claim 1, wherein the system does not include a lysis magnet at an inferior position to the tray.
- Claim:
28. The system according to claim 1, further comprising the multi-microwell-array-flowcell cartridge, wherein multi-microwell-array-flowcell cartridge comprises: a plurality of fluidic lanes, each fluidic lane comprising: an inlet for receiving liquid; a flow cell comprising a microwell array; and an outlet for discharging liquid.
- Claim:
29-30. (canceled)
- Claim:
31. The system according to claim 28, wherein each outlet is stepped to prevent siphoning of liquid from the flow cell.
- Claim:
32. The system according to claim 28, wherein each flow cell is comprised of an elongate channel.
- Claim:
33-35. (canceled)
- Claim:
36. The system according to claim 28, wherein the tray has a shape that is complementary to the shape of the multi-microwell-array-flowcell cartridge such that the multi-microwell-array-flowcell cartridge may be received in the tray in a single orientation.
- Claim:
37-129. (canceled)
- Current International Class:
12; 01; 12; 12; 01
- الرقم المعرف:
edspap.20240263233
Processing Request
No Comments.