- Document Number:
20230225974
- Appl. No:
17/998188
- Application Filed:
May 11, 2021
- نبذة مختصرة :
Solid solution of gum arabic and at least one liposoluble active ingredient having particles of a size of less than 100 µm and a weight ratio of gum arabic to liposoluble active ingredients of 5:1 to 200:1, obtainable by drying an aqueous solution of gum arabic to achieve a fine-particle dry product; admixing the dry product with a solution or dispersion of the liposoluble active ingredient(s) in an anhydrous solvent in which gum arabic is insoluble; mixing in the solution while homogenizing and further comminuting the dry product to a particle size of less than 100 µm; and removing the solvent at a temperature of less than 70° C., as well as method for the preparation of the solution and the aqueous suspension containing it.
- Assignees:
Metabolic Tuning AG (Tuebach, CH)
- Claim:
1. Solid solution of gum arabic and at least one liposoluble active ingredient having particles of a size of less than 100 µm and a weight ratio of gum arabic to liposoluble active ingredients of between 5:1 and 200:1, obtainable by drying of an aqueous solution of gum arabic to produce a fine-particle dry product; admixing the dry product with a solution or dispersion of the liposoluble active ingredient(s) in an anhydrous solvent in which gum arabic is insoluble; mixing in the solution while homogenizing and further fragmenting the dry product to a particle size of less than 100 µm; and removing the solvent at a temperature ≤ 70° C., preferably at ≤ 40° C.
- Claim:
2. Solid solution according to claim 1, characterized in that the particles consisting of gum arabic and at least one liposoluble active ingredient form micelles.
- Claim:
3. Solid solution according to claim 2, characterized in that the weight ratio of gum arabic to liposoluble active ingredients ranges between 50:1 and 100:1.
- Claim:
4. Solid solution according to claim 1, characterized in that 80% of the particles have a size of ≤ 60 µm.
- Claim:
5. Solid solution according to claim 4, characterized in that 80% of the particles have a size of ≤ 40 µm.
- Claim:
6. Solid solution according to claim 1, characterized in that the fine-particle dry product is spray-dried gum arabic.
- Claim:
7. Solid solution according to claim 1, characterized in that the solvent of the solution or dispersion of the liposoluble active ingredient(s) is absolute alcohol.
- Claim:
8. Method for preparing a solid solution of gum arabic and at least one liposoluble active ingredient, characterized by the steps of drying of an aqueous solution of gum arabic to produce a fine-particle dry product; adding to the fine-particle dry product a solution or dispersion of the liposoluble active ingredient(s) in an anhydrous solvent in which gum arabic is insoluble, in a weight ratio of gum arabic to liposoluble active ingredient(s) ranging between 20:1 and 200:1; mixing in the solution while homogenizing and further fragmenting the dry product to a particle size smaller than 100 µm; and removing the solvent at a temperature of ≤ 70° C., preferably at ≤ 40° C.
- Claim:
9. Method according to claim 8, characterized in that spray-dried gum arabic is used as dry product.
- Claim:
10. Method according to claim 8, characterized in that further fragmentation is performed by means of a cutter or sonicator.
- Claim:
11. Method according to claim 8, characterized in that further fragmentation is carried out under high shear until 80% of the particles have a size of ≤ 60 µm.
- Claim:
12. Method according to claim 11, characterized in that further fragmentation is performed until 80% of the particles have a size of ≤ 40 µm.
- Claim:
13. Method according to claim 8, characterized in that a weight ratio of gum arabic to liposoluble active ingredients of 1:50 to 1:100 is used.
- Claim:
14. Method according to claim 8, characterized in that absolute alcohol is used as solvent.
- Claim:
15. Aqueous suspension containing 2.0 to 40.0 wt% of the solid solution of gum arabic according to claim 1.
- Claim:
16. Aqueous suspension according to claim 15, characterized in that said suspension additionally contains customary food-grade preservative agents, stabilizers, pH regulators, sweeteners and/or flavoring agents in an amount, taken together, of 0.05 to 1.0 wt%.
- Claim:
17. Aqueous suspension according to claim 15, characterized in that said suspension additionally contains water-soluble vitamins, provitamins, nutrients and/or nutritional supplements in an amount, taken together, of 0.5 to 2.5 wt%.
- Claim:
18. Solid solution according to claim 1, characterized in that the active ingredient or one of the active ingredients is co-enzyme Q10 and/or curcumin.
- Current International Class:
61; 61; 61; 23; 23; 23
- الرقم المعرف:
edspap.20230225974
Processing Request
No Comments.