- Document Number:
20230162861
- Appl. No:
17/996849
- Application Filed:
April 26, 2021
- نبذة مختصرة :
Functional magnetic resonance imaging (“fMRI”) processing that makes use of both the magnitude and phase information contained in magnetic resonance signals is implemented to enhance the visualization of blood-oxygenation-level-dependent (“BOLD”) fMRI activation. As a result, the functional activation maps generated with these techniques are more sensitive to subtle neuronal activity than maps generated with conventional fMRI techniques, which utilize only magnitude information.
- Claim:
1. A method for generating a functional activation map indicative of neuronal activity in a subject, the method comprising: (a) accessing functional magnetic resonance imaging (fMRI) data with a computer system, wherein the fMRI data comprise a time-series of images containing magnitude information and phase information, the time-series of images being acquired from a subject using an MRI system; (b) extracting phase images from the fMRI data using the computer system, wherein each phase image depicts the phase information in the fMRI data; (c) generating one or more phase masks from the phase images with the computer system, wherein each phase mask scales phase information in the phase image to a range of values; (d) generating susceptibility-enhanced images with the computer system by applying the one or more phase masks to the magnitude information in the fMRI data, generating output as the susceptibility-enhanced images; and (e) generating a functional activation map from the susceptibility-enhanced images using the computer system, wherein the functional activation map depicts neuronal activity that occurred in the subject when the fMRI data were acquired.
- Claim:
2. The method of claim 1, wherein generating the one or more phase masks comprises filtering the phase images to generate filtered phase images and generating the one or more phase masks from the filtered phase images.
- Claim:
3. The method of claim 2, wherein the filtered phase images are generated by applying a high-pass filter to the phase images.
- Claim:
4. The method of claim 1, wherein each phase mask is generated by mapping phase values in the phase images to the range of values comprising 0 to 1.
- Claim:
5. The method of claim 4, wherein phase values in a first range are mapped to values of 1 in each phase mask, and phase values in a second range are mapped to values from 0 up to 1 in each phase mask.
- Claim:
6. The method of claim 5, wherein the first range and the second range are selected such that each phase mask is a diamagnetic phase mask.
- Claim:
7. The method of claim 5, wherein the first range and the second range are selected such that each phase mask is a paramagnetic phase mask.
- Claim:
8. The method of claim 5, wherein phase values in the second range are mapped using a mapping function.
- Claim:
9. The method of claim 8, wherein the mapping function is a linear function.
- Claim:
10. The method of claim 8, wherein the mapping function is a power function.
- Claim:
11. The method of claim 1, wherein generating the susceptibility-enhanced images comprises extracting magnitude images from the fMRI data and multiplying each magnitude image by a corresponding one of the one or more phase masks.
- Claim:
12. The method of claim 11, wherein each magnitude image is repeatedly multiplied by the corresponding one of the one or more phase masks.
- Claim:
13. The method of claim 1, wherein accessing the fMRI data with the computer system comprises controlling the MRI system to acquire the fMRI data and to communicate the fMRI data to the computer system.
- Claim:
14. The method of claim 1, wherein the fMRI data comprise the time-series of images being acquired from the subject while the subject performed a functional task, and wherein the functional activation map depicts neuronal activity associated with the functional task.
- Claim:
15. The method of claim 1, wherein the fMRI data comprise the time-series of images being acquired from the subject during a resting state, and wherein the functional activation map depicts neuronal activity associated with the resting state.
- Current International Class:
16; 61
- الرقم المعرف:
edspap.20230162861
Processing Request
No Comments.