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CLOSED-LOOP SIMULTANEOUS FUNCTIONAL MAGNETIC RESONANCE IMAGING (fMRI)-ELECTROENCEPHALOGRAM (EEG)-TRANSCRANIAL MAGNETIC STIMULATION (TMS) SYSTEM

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اقرأ أكثر حفظ في قائمتي
  • Publication Date:
    May 11, 2023
  • معلومة اضافية
    • Document Number:
      20230143233
    • Appl. No:
      18/054447
    • Application Filed:
      November 10, 2022
    • نبذة مختصرة :
      The present subject matter relates to techniques for systems and methods for determining alpha phase in brain of subjects undergoing depressive disorder. The disclosed system for a closed-loop operation in simultaneous functional magnetic resonance imaging (fMRI)-electroencephalogram (EEG)-transcranial magnetic stimulation (TMS), can include a processor that be configured to receive and process a functional magnetic resonance imaging (fMRI) data and/or an extracranial electroencephalogram (EEG) data and/or transcranial magnetic stimulation (TMS) pulse simultaneously.
    • Assignees:
      THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, NY, US), MEDICAL UNIVERSITY OF SOUTH CAROLINA (Charleston, SC, US)
    • Claim:
      1. A system for identifying an alpha phase in brain of a subject, comprising: a processor configured to: process one or more of functional magnetic resonance imaging (fMRI) data and electroencephalogram (EEG) data, wherein the fMRI data and EEG data are simultaneously acquired; trigger a transcranial magnetic stimulation (TMS) pulse; analyze the fMRI data if any, the EEG data if any and the TMS pulse; and determine the alpha phase, wherein the alpha phase evokes strong activity in dorsal anterior cingulate cortex (dACC).
    • Claim:
      2. The system of claim 1, wherein the processor further is configured to determine a target alpha phase associated with the strong response in the dACC as measured by blood oxygen level dependent (BOLD) signal.
    • Claim:
      3. The system of claim 1, wherein the EEG data is acquired using a MR-compatible EEG system.
    • Claim:
      4. The system of claim 1, wherein a level of activation of the anterior cingulate cortex (ACC) varies with the TMS pulse applied to dorsal lateral prefrontal cortex (DLPFC).
    • Claim:
      5. The system of claim 5, wherein the DLPFC is depended on timing of the applied TMS pulses relative to the phase of an EEG alpha rhythm of the subject.
    • Claim:
      6. The system of claim 1, wherein the alpha phase is determined in the EEG data at the time of each TMS pulse.
    • Claim:
      7. The system of claim 1, wherein the TMS pulse is synchronized to the patient's prefrontal quasi-alpha rhythm.
    • Claim:
      8. A closed-loop electroencephalogram (EEG)-repetitive transcranial magnetic stimulation (rTMS) system, comprising: a processor configured to acquire EEG data; trigger a rTMS pulse; process the EEG data and the rTMS pulse; and determine a target alpha phase, wherein a first alpha phase is determined before the target alpha phase is determined.
    • Claim:
      9. The system of claim 8, wherein rTMS is synchronized to the EEG alpha phase.
    • Claim:
      10. The system of claim 8, wherein the first alpha phase is determined by functional magnetic resonance imaging (fMRI) data, electroencephalogram (EEG) data, and a trigger transcranial magnetic stimulation (TMS) pulse.
    • Claim:
      11. A method of determining a target alpha phase in brain of a subject, comprising: performing a first simultaneous scan to determine a first alpha phase which evoked strongest activity in dorsal cingulate cortex (dACC); performing a treatment of multiple sessions to the subject; and performing a second simultaneous scan at the end of the subject's treatment to determine a target alpha phase after the treatment was complete; wherein the simultaneous scan uses functional magnetic resonance imaging (fMRI) data, electroencephalogram (EEG) data, and a trigger transcranial magnetic stimulation (TMS) pulse.
    • Claim:
      12. The method of claim 11, wherein a simultaneous EEG is recorded.
    • Claim:
      13. The method of claim 11, wherein a motor threshold is measured on the subject's left motor cortex.
    • Claim:
      14. The method of claim 13, further comprising adjusting a TMS output voltage until an involuntary thumb twitch is observed in the patient before the scan.
    • Claim:
      15. A method for treating depressive disorder, comprising delivering EEG-triggered repetitive transcranial magnetic stimulation (rTMS) to a subject, wherein the rTMS is synchronized to the subject's prefrontal EEG quasi-alpha rhythm.
    • Claim:
      16. The method of claim 16, the rTMS is applied on the dorsal prefrontal cortex (DLPFC).
    • Current International Class:
      61; 61; 61; 61
    • الرقم المعرف:
      edspap.20230143233