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ANTI-CONNEXIN COMPOUNDS TARGETED TO CONNEXINS AND METHODS OF USE THEREOF

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اقرأ أكثر حفظ في قائمتي
  • Publication Date:
    March 18, 2021
  • معلومة اضافية
    • Document Number:
      20210079396
    • Appl. No:
      17/033278
    • Application Filed:
      September 25, 2020
    • نبذة مختصرة :
      Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable.
    • Claim:
      1-16. (canceled)
    • Claim:
      17. A method for reducing tissue damage associated with an ophthalmic procedure in a subject, comprising administering an antisense compound to the eye of said subject in conjunction with said procedure in an amount sufficient to inhibit the expression of a connexin protein in the eye or in cells associated with the eye of said subject, wherein said antisense compound comprises a nucleobase sequence selected from SEQ ID NOs: 4-11.
    • Claim:
      18. The method of claim 1, wherein said antisense compound is administered by local or topical administration.
    • Claim:
      19. The method of claim 1, wherein said antisense compound is administered by direct application in a surgical wound.
    • Claim:
      20. The method of claim 1, wherein said antisense compound is administered by intraocular injection.
    • Claim:
      21. The method of claim 1, wherein said antisense compound is used in combination with a second compound useful for reducing tissue damage or promoting healing.
    • Claim:
      22. The method of claim 1, wherein said second compound is a growth factor or cytokine.
    • Claim:
      23. The method of claim 6, wherein said second compound is selected from a growth factor, cytokine, or the like, including but not limited to FGF, NGF, NT3, PDGF, TGF, VEGF, BDGF, EGF, KGF, integrins, interleukins, plasmin, and semaphorins.
    • Claim:
      24. The method of claim 1, wherein said antisense compound is targeted towards connexin 26, 37, 30 and/or 31.1.
    • Current International Class:
      12; 12; 61; 61
    • الرقم المعرف:
      edspap.20210079396