- Document Number:
20210023375
- Appl. No:
16/980259
- Application Filed:
March 14, 2019
- نبذة مختصرة :
The disclosed apparatus, systems and methods relate to the use of spinal cord stimulation (SCS) in the treatment of conditions correlated to the sympathetic nervous system. Stimulating the spinal cord via SCS to decrease muscle sympathetic nerve activity (MSNA). The methods include providing acute spinal cord stimulation and selectively increasing blood flow to tissues that are physically associated with the stimulated nerves, which is used to normalize blood pressure in hypertensive or hypotensive patients. The methods establish that acute SCS rapidly increases femoral vascular conductance and reduces peroneal MSNA.
- Claim:
1. A method for selectively reducing the activity of the sympathetic nervous system of a patient in need thereof, comprising: a. implanting a pulse generator in the patient, the pulse generator having one or more leads; and b. stimulating one or more nerves associated with the spinal cord of the patient.
- Claim:
2. The method of claim 1, further comprising selectively stimulating the nerve at an intensity for a duration such that blood flow is increased to a tissue innervated by the nerve.
- Claim:
3. The method of claim 2, wherein the tissue is an artery.
- Claim:
4. The method of claim 2, wherein the one or more nerves are physically associated with the tissue.
- Claim:
5. The method of claim 1, further comprising selectively stimulating the nerve at an intensity for a duration such that blood pressure is normalized.
- Claim:
6. The method of claim 1, wherein the one or more nerves are sympathetic nerves.
- Claim:
7. The method of claim 1, wherein the patient is diabetic.
- Claim:
8. The method of claim 1, wherein the patient is hypertensive.
- Claim:
9. The method of claim 8, wherein the patient is undergoing an anti-hypertensive medication regimen.
- Claim:
10. The method of claim 8, wherein the patient has resistant autonomic overactive hypertension or resistant central neurogenic hypertension.
- Claim:
11. The method of claim 1, wherein stimulation is applied at voltages between about 1.0V and about 10.0V.
- Claim:
12. The method of claim 1, wherein the stimulation is applied at pulse widths ranging from about 40 μs to about 1000 μs.
- Claim:
13. The method of claim 1, wherein the stimulation is applied at frequencies from about 20 Hz to about 400 Hz.
- Claim:
14. A method for selectively reducing the activity of the sympathetic nervous system in a hypertensive patient, comprising: a. implanting a pulse generator in the patient, the pulse generator having one or more leads; and b. stimulating one or more neural tissues associated with the spinal cord of the patient, wherein the neural tissue stimulation reduces patient blood pressure.
- Claim:
15. The method of claim 14, wherein the patient is undergoing an anti-hypertensive medication regimen.
- Claim:
16. The method of claim 14, wherein the patient has resistant autonomic overactive hypertension or resistant central neurogenic hypertension.
- Claim:
17. A method of selectively reducing muscle sympathetic nerve activity in a patient, comprising: a. implanting a pulse generator in the patient, the pulse generator having one or more leads; and b. stimulating one or more nerves associated with the spinal cord of the patient, wherein the nerve stimulation increases femoral vascular conductance.
- Claim:
18. The method of claim 17, wherein the patient has neuropathic pain or is diabetic.
- Claim:
19. The method of claim 17, wherein the stimulation is applied for between about 5 and about 60 minutes.
- Claim:
20. The method of claim 17, wherein femoral artery conductance is elevated over brachial artery conductance.
- Current International Class:
61; 61; 61
- الرقم المعرف:
edspap.20210023375
Processing Request
No Comments.